{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T05:01:52Z","timestamp":1750050112781,"version":"3.28.0"},"reference-count":19,"publisher":"Texas Heart Institute Journal","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Driveline infection has been a persistent problem with mechanical cardiac assist devices. The reported incidence of infection has been low in patients who receive a Jarvik 2000 continuous-flow left ventricular assist device when a skull-pedestal driveline exit site is used. We evaluated whether this is also true when a subcostal driveline exit site is used.<\/jats:p>\n        <jats:p>We reviewed baseline demographic variables, postimplantation vital signs, laboratory values, and culture results in patients who underwent Jarvik 2000 implantation at our center from April 2000 through October 2009, including follow-up through June 2014. All patients had a subcostal driveline exit site. We defined device-related infection as a positive blood or wound culture associated with a medical or surgical device intervention. Event and time-to-event rates were calculated.<\/jats:p>\n        <jats:p>Eighty-one patients received 89 Jarvik 2000 devices, all as bridges to transplantation. The median support duration was 69 days (interquartile range, 27\u2013153 d; range, 2\u20132,249 d). Five superficial driveline infections and one incision-site infection occurred (0.002 events per patient-year of support). The median time from pump implantation to onset of driveline infection was 30 days; the incision-related infection occurred at 44 days.<\/jats:p>\n        <jats:p>The Jarvik 2000 has a low incidence of infection when implanted with use of a subcostal driveline exit site. The incidence of pump infections is particularly low. Using a subcostal driveline exit site may be as effective in preventing infections as using a skull-pedestal driveline exit site. We detail our findings in this report.<\/jats:p>","DOI":"10.14503\/thij-15-5708","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T15:59:21Z","timestamp":1572537561000},"page":"179-182","source":"Crossref","is-referenced-by-count":4,"title":["Low Incidence of Pump-Related Infections in Jarvik 2000 Ventricular Assist Device Recipients with a Subcostal Driveline Exit Site"],"prefix":"10.14503","volume":"46","author":[{"given":"George V.","family":"Letsou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jatin","family":"Anand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erinn","family":"Ogburn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan M.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand V.","family":"Ganapathy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Cohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Loor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.H.","family":"Frazier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"key":"i1526-6702-46-3-179-b1","unstructured":"World Health Organization. \n          Global status report on noncommunicable diseases 2010. Description of the global burden of NCDs, their risk factors and determinants. Available from: http:\/\/www.who.int\/nmh\/publications\/ncd_report2010\/en [cited 2015 Jan 9].","article-title":"Global status report on noncommunicable diseases 2010. Description of the global burden of NCDs, their risk factors and determinants"},{"issue":"20","key":"i1526-6702-46-3-179-b2","series-title":"N Engl J Med","first-page":"1435","article-title":"Long-term use of a left ventricular assist device for end-stage heart failure","volume":"345","year":"2001","unstructured":"Rose\n              EA\n            , GelijnsAC, MoskowitzAJ, HeitjanDF, StevensonLW, DembitskyW, \n          et al. Long-term use of a left ventricular assist device for end-stage heart failure. 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Pre-operative risk factors of bleeding and stroke during left ventricular assist device support: an analysis of more than 900 HeartMate II outpatients. J Am Coll Cardiol2014;63(9):880\u20138."},{"issue":"1","key":"i1526-6702-46-3-179-b5","series-title":"J Heart Lung Transplant","first-page":"35","article-title":"Hemolysis: a harbinger of adverse outcome after left ventricular assist device implant","volume":"33","year":"2014","unstructured":"Cowger\n              JA\n            , RomanoMA, ShahP, ShahN, MehtaV, HaftJW, \n          et al. Hemolysis: a harbinger of adverse outcome after left ventricular assist device implant. J Heart Lung Transplant2014;33(1):35\u201343."},{"issue":"4","key":"i1526-6702-46-3-179-b6","series-title":"Ann Thorac Surg","first-page":"1373","article-title":"Percutaneous lead dysfunction in the HeartMate II left ventricular assist device","volume":"97","year":"2014","unstructured":"Kalavrouziotis\n              D\n            , TongMZ, StarlingRC, MassielloA, SolteszE, SmediraNG, \n          et al. Percutaneous lead dysfunction in the HeartMate II left ventricular assist device. Ann Thorac Surg2014;97(4):1373\u20138."},{"issue":"1","key":"i1526-6702-46-3-179-b7","series-title":"Gen Thorac Cardiovasc Surg","first-page":"1","article-title":"Clinical management for complications related to implantable LVAD use","volume":"63","year":"2015","unstructured":"Toda\n              K\n            , SawaY.\n          Clinical management for complications related to implantable LVAD use. 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Clinical manifestations and management of left ventricular assist device-associated infections. Clin Infect Dis2013;57(10):1438\u201348."},{"issue":"3","key":"i1526-6702-46-3-179-b13","series-title":"J Congest Heart Fail Circ Support","first-page":"133","article-title":"Development of the Jarvik 2000 intraventricular axial-flow left ventricular assist system","volume":"1","year":"2000","unstructured":"Myers\n              TJ\n            , GregoricI, TamezD, JarvikR, FrazierO, InmanRW, \n          et al. Development of the Jarvik 2000 intraventricular axial-flow left ventricular assist system. J Congest Heart Fail Circ Support2000;1(3):133\u201340. Abstract available at: https:\/\/www.ingentaconnect.com\/content\/tandf\/jcs\/2000\/00000001\/00000003\/art00006."},{"issue":"5","key":"i1526-6702-46-3-179-b14","series-title":"Ann Cardiothorac Surg","first-page":"525","article-title":"The Jarvik-2000 ventricular assist device implantation: how we do it","volume":"3","year":"2014","unstructured":"Zucchetta\n              F\n            , TarziaV, BottioT, GerosaG.\n          The Jarvik-2000 ventricular assist device implantation: how we do it. Ann Cardiothorac Surg2014;3(5):525\u201331."},{"key":"i1526-6702-46-3-179-b15","unstructured":"Jarvik Heart, Inc. \n          Clinical protocol for evaluation of the Jarvik 2000 heart assist system. 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The Jarvik 2000 is associated with less infections than the HeartMate left ventricular assist device. Eur J Cardiothorac Surg2003;23(5):748\u201355."},{"issue":"4","key":"i1526-6702-46-3-179-b19","series-title":"ASAIO J","first-page":"461","article-title":"Multicenter experience: prevention and management of left ventricular assist device infections","volume":"51","year":"2005","unstructured":"Chinn\n              R\n            , DembitskyW, EatonL, ChillcottS, StahovichM, RasmussonB, PaganiF.\n          Multicenter experience: prevention and management of left ventricular assist device infections. 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