{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:44:35Z","timestamp":1767084275032,"version":"3.28.0"},"reference-count":22,"publisher":"Texas Heart Institute Journal","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>Four novel oral anticoagulant agents are currently available for the prevention and treatment of thromboembolic events in patients with nonvalvular atrial fibrillation. We present an unusual case of spontaneous hemopericardium and tamponade in an 87-year-old man with atrial fibrillation who was taking one such agent, dabigatran, as thromboprophylaxis.<\/jats:p>\n        <jats:p>Our case highlights both a rare bleeding complication of dabigatran use and the effectiveness of idarucizumab, its newly approved reversal agent. Especially in elderly patients, we recommend that clinicians evaluate risk factors, closely monitor patient status, and consider alternatives to the newer anticoagulants when the risk of bleeding is high.<\/jats:p>","DOI":"10.14503\/thij-16-6073","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T21:07:00Z","timestamp":1509484020000},"page":"370-372","source":"Crossref","is-referenced-by-count":8,"title":["Dabigatran-Induced Spontaneous Hemopericardium and Cardiac Tamponade"],"prefix":"10.14503","volume":"44","author":[{"given":"Qurat-ul-ain","family":"Jelani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Schussheim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"12","key":"i1526-6702-44-5-370-b1","series-title":"N Engl J Med","first-page":"1139","article-title":"Dabigatran versus warfarin in patients with atrial fibrillation [published erratum appears in N Engl J Med 2010;363(19):1877]","volume":"361","year":"2009","unstructured":"Connolly\n              SJ\n            , EzekowitzMD, YusufS, EikelboomJ, OldgrenJ, ParekhA, \n          et al. Dabigatran versus warfarin in patients with atrial fibrillation [published erratum appears in N Engl J Med 2010;363(19):1877]. N Engl J Med2009;361(12):1139\u201351."},{"issue":"5","key":"i1526-6702-44-5-370-b2","series-title":"Pharmacotherapy","first-page":"e103","article-title":"Hemopericardium in a patient treated with dabigatran etexilate","volume":"32","year":"2012","unstructured":"Barton\n              CA\n            , McMillianWD, RazaSS, KellerRE.\n          Hemopericardium in a patient treated with dabigatran etexilate. Pharmacotherapy2012;32(5):e103\u20137."},{"issue":"8","key":"i1526-6702-44-5-370-b3","series-title":"Am J Cardiol","first-page":"1142","article-title":"Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population","volume":"112","year":"2013","unstructured":"Colilla\n              S\n            , CrowA, PetkunW, SingerDE, SimonT, LiuX.\n          Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population. 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JAMA1969;209(9):1362\u20134."},{"issue":"6","key":"i1526-6702-44-5-370-b14","series-title":"J R Soc Promot Health","first-page":"324","article-title":"Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin","volume":"128","year":"2008","unstructured":"Griffiths\n              AP\n            , BeddallA, PeglerS.\n          Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin. J R Soc Promot Health2008;128(6):324\u20136."},{"issue":"8","key":"i1526-6702-44-5-370-b15","series-title":"QJM","first-page":"575","article-title":"Spontaneous haemopericardium with subacute cardiac tamponade in a patient with lung cancer receiving coumadin","volume":"102","year":"2009","unstructured":"Braiteh\n              F\n            , PlanaJC.\n          Spontaneous haemopericardium with subacute cardiac tamponade in a patient with lung cancer receiving coumadin. QJM2009;102(8):575."},{"key":"i1526-6702-44-5-370-b16","series-title":"BMJ Case Rep","article-title":"Cardiac tamponade secondary to haemopericardium in a patient on warfarin","volume":"2010","year":"2010","unstructured":"Al-Jundi\n              W\n            , RubinN.\n          Cardiac tamponade secondary to haemopericardium in a patient on warfarin. BMJ Case Rep2010;2010."},{"issue":"9","key":"i1526-6702-44-5-370-b17","series-title":"Emerg Med J","first-page":"679","article-title":"Cardiac tamponade secondary to haemopericardium in a patient on warfarin","volume":"24","year":"2007","unstructured":"Hong\n              YC\n            , ChenYG, HsiaoCT, KuanJT, ChiuTF, ChenJC.\n          Cardiac tamponade secondary to haemopericardium in a patient on warfarin. 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AMA Arch Intern Med1951;87(5):727\u201331."},{"issue":"2","key":"i1526-6702-44-5-370-b20","series-title":"Blood Coagul Fibrinolysis","first-page":"185","article-title":"Hemopericardium under dabigatran for stroke prevention in atrial fibrillation","volume":"28","year":"2017","unstructured":"Stollberger\n              C\n            , HegerM, FinstererJ.\n          Hemopericardium under dabigatran for stroke prevention in atrial fibrillation. Blood Coagul Fibrinolysis2017;28(2):185\u20138."},{"issue":"1","key":"i1526-6702-44-5-370-b21","series-title":"Korean Circ J","first-page":"99","article-title":"Hemopericardium and cardiac tamponade in a patient treated with dabigatran etexilate","volume":"46","year":"2016","unstructured":"Kizilirmak\n              F\n            , GunesHM, GulerE, DemirGG, KaracaO, CanpolatHG.\n          Hemopericardium and cardiac tamponade in a patient treated with dabigatran etexilate. 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