{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:52:30Z","timestamp":1782604350496,"version":"3.54.5"},"reference-count":11,"publisher":"Texas Heart Institute Journal","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Platypnea-orthodeoxia syndrome, a rare condition characterized by posture-related dyspnea, is usually caused by an intracardiac shunt, hepatopulmonary syndrome, or shunting resulting from severe pulmonary disease.<\/jats:p>\n        <jats:p>We report the case of a 33-year-old woman who presented with increasing dyspnea and oxygen desaturation when she sat up or arose. Our diagnosis was platypnea-orthodeoxia syndrome. A lead of a previously implanted pacemaker exacerbated a severe tricuspid regurgitant jet that was directed toward the patient's intra-atrial septum. Percutaneous closure of a small secundum atrial septal defect eliminated right-to-left shunting and substantially improved the patient's functional status. In addition to this case, we discuss this unusual condition.<\/jats:p>","DOI":"10.14503\/thij-16-6094","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T23:30:06Z","timestamp":1611185406000},"page":"298-301","source":"Crossref","is-referenced-by-count":6,"title":["Platypnea-Orthodeoxia Syndrome Caused by an Intracardiac Shunt"],"prefix":"10.14503","volume":"47","author":[{"given":"Sanket P.","family":"Borgaonkar","sequence":"first","affiliation":[{"name":"Department of Medicine, Texas Heart Institute and Baylor\u2013St. Luke's Medical Center; Houston, Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson W.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Texas Heart Institute and Baylor\u2013St. Luke's Medical Center; Houston, Texas 77030"},{"name":"Texas Heart Institute; and Department of Cardiology, Texas Heart Institute and Baylor\u2013St. Luke's Medical Center; Houston, Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Razavi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Texas Heart Institute and Baylor\u2013St. Luke's Medical Center; Houston, Texas 77030"},{"name":"Baylor College of Medicine; Department of Electrophysiology Clinical Research and Innovations, Texas Heart Institute and Baylor\u2013St. Luke's Medical Center; Houston, Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhaval R.","family":"Parekh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Texas Heart Institute and Baylor\u2013St. Luke's Medical Center; Houston, Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5628","reference":[{"issue":"10","key":"i1526-6702-47-4-298-b1","series-title":"Clin Cardiol","first-page":"645","article-title":"Cardiac platypnea-orthodeoxia syndrome: an often unrecognized malady","volume":"37","year":"2014","unstructured":"Knapper\n              JT,\n            \n            \n              Schultz\n              J,\n            \n            \n              Das\n              G,\n            \n            \n              Sperling\n              LS.\n            \n          \n          Cardiac platypnea-orthodeoxia syndrome: an often unrecognized malady.\n\t\t\t\t\tClin Cardiol2014;37(10):645\u20139."},{"issue":"2","key":"i1526-6702-47-4-298-b2","series-title":"Angiology","first-page":"79","article-title":"Persistent Eustachian valve causing severe cyanosis in atrial septal defect with normal right heart pressures","volume":"34","year":"1983","unstructured":"Bashour\n              T,\n            \n            \n              Kabbani\n              S,\n            \n            \n              Saalouke\n              M,\n            \n            \n              Cheng\n              TO.\n            \n          \n          Persistent Eustachian valve causing severe cyanosis in atrial septal defect with normal right heart pressures.\n\t\t\t\t\tAngiology1983;34(2):79\u201383."},{"issue":"11","key":"i1526-6702-47-4-298-b3","series-title":"Am J Med","first-page":"890","article-title":"Platypnea-orthodeoxia syndrome occurring after a blunt chest trauma with acute tricuspid regurgitation","volume":"117","year":"2004","unstructured":"Hsu\n              PF,\n            \n            \n              Leu\n              HB,\n            \n            \n              Lu\n              TM,\n            \n            \n              Yu\n              WC,\n            \n            \n              Hsu\n              TL.\n            \n          \n          Platypnea-orthodeoxia syndrome occurring after a blunt chest trauma with acute tricuspid regurgitation.\n\t\t\t\t\tAm J Med2004;117(11):890\u20131."},{"issue":"2","key":"i1526-6702-47-4-298-b4","series-title":"Tex Heart Inst J","first-page":"171","article-title":"Stepwise progression of right-to-left atrial shunting through a combination of patent foramen ovale and tricuspid regurgitation","volume":"43","year":"2016","unstructured":"Kransdorf\n              EP,\n            \n            \n              Kransdorf\n              LN,\n            \n            \n              Fortuin\n              FD,\n            \n            \n              Sweeney\n              JP,\n            \n            \n              Wilansky\n              S.\n            \n          \n          Stepwise progression of right-to-left atrial shunting through a combination of patent foramen ovale and tricuspid regurgitation.\n\t\t\t\t\tTex Heart Inst J2016;43(2):171\u20134."},{"issue":"2","key":"i1526-6702-47-4-298-b5","series-title":"Heart","first-page":"221","article-title":"Platypnoea-orthodeoxia syndrome","volume":"83","year":"2000","unstructured":"Kubler\n              P,\n            \n            \n              Gibbs\n              H,\n            \n            \n              Garrahy\n              P.\n            \n          \n          Platypnoea-orthodeoxia syndrome.\n\t\t\t\t\tHeart2000;83(2):221\u20133."},{"issue":"23","key":"i1526-6702-47-4-298-b6","series-title":"J Am Coll Cardiol","first-page":"e143","article-title":"ACC\/AHA 2008 guidelines for the management of adults with congenital heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to develop guidelines on the management of adults with congenital heart disease). Developed in collaboration with the American Society of Echocardiography, Heart Rhythm Society, International Society for Adult Congenital Heart Disease, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons","volume":"52","year":"2008","unstructured":"Warnes\n              CA,\n            \n            \n              Williams\n              RG,\n            \n            \n              Bashore\n              TM,\n            \n            \n              Child\n              JS,\n            \n            \n              Connolly\n              HM,\n            \n            \n              Dearani\n              JA,\n            \n          \n          .\n\t\t\t\t\tACC\/AHA 2008 guidelines for the management of adults with congenital heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to develop guidelines on the management of adults with congenital heart disease). Developed in collaboration with the American Society of Echocardiography, Heart Rhythm Society, International Society for Adult Congenital Heart Disease, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons.\n\t\t\t\t\tJ Am Coll Cardiol2008;52(23):e143\u2013263."},{"issue":"10","key":"i1526-6702-47-4-298-b7","series-title":"J Invasive Cardiol","first-page":"583","article-title":"Transcatheter management of platypnea-orthodeoxia syndrome","volume":"16","year":"2004","unstructured":"Rao\n              PS.\n            \n          \n          Transcatheter management of platypnea-orthodeoxia syndrome.\n\t\t\t\t\tJ Invasive Cardiol2004;16(10):583\u20134."},{"issue":"20","key":"i1526-6702-47-4-298-b8","series-title":"Circulation","first-page":"2391","article-title":"Transvenous pacing leads and systemic thromboemboli in patients with intracardiac shunts: a multicenter study","volume":"113","year":"2006","unstructured":"Khairy\n              P,\n            \n            \n              Landzberg\n              MJ,\n            \n            \n              Gatzoulis\n              MA,\n            \n            \n              Mercier\n              LA,\n            \n            \n              Fernandes\n              SM,\n            \n            \n              Cote\n              JM,\n            \n          \n          .\n\t\t\t\t\tTransvenous pacing leads and systemic thromboemboli in patients with intracardiac shunts: a multicenter study.\n\t\t\t\t\tCirculation2006;113(20):2391\u20137."},{"issue":"10","key":"i1526-6702-47-4-298-b9","series-title":"Can J Cardiol","first-page":"e1","article-title":"PACES\/HRS expert consensus statement on the recognition and management of arrhythmias in adult congenital heart disease: developed in partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Endorsed by the governing bodies of PACES, HRS, the American College of Cardiology (ACC), the American Heart Association (AHA), the European Heart Rhythm Association (EHRA), the Canadian Heart Rhythm Society (CHRS), and the International Society for Adult Congenital Heart Disease (ISACHD)","volume":"30","year":"2014","unstructured":"Khairy\n              P,\n            \n            \n              Van Hare\n              GF,\n            \n            \n              Balaji\n              S,\n            \n            \n              Berul\n              CI,\n            \n            \n              Cecchin\n              F,\n            \n            \n              Cohen\n              MI,\n            \n          \n          .\n\t\t\t\t\tPACES\/HRS expert consensus statement on the recognition and management of arrhythmias in adult congenital heart disease: developed in partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Endorsed by the governing bodies of PACES, HRS, the American College of Cardiology (ACC), the American Heart Association (AHA), the European Heart Rhythm Association (EHRA), the Canadian Heart Rhythm Society (CHRS), and the International Society for Adult Congenital Heart Disease (ISACHD).\n\t\t\t\t\tCan J Cardiol2014;30(10):e1\u201363."},{"issue":"2","key":"i1526-6702-47-4-298-b10","series-title":"Cardiovasc Intervent Radiol","first-page":"164","article-title":"Transcatheter closure of patent foramen ovale in patients with platypnea-orthodeoxia: results of a multicentric French registry","volume":"28","year":"2005","unstructured":"Guerin\n              P,\n            \n            \n              Lambert\n              V,\n            \n            \n              Godart\n              F,\n            \n            \n              Legendre\n              A,\n            \n            \n              Petit\n              J,\n            \n            \n              Bourlon\n              F,\n            \n          \n          .\n\t\t\t\t\tTranscatheter closure of patent foramen ovale in patients with platypnea-orthodeoxia: results of a multicentric French registry.\n\t\t\t\t\tCardiovasc Intervent Radiol2005;28(2):164\u20138."},{"issue":"1","key":"i1526-6702-47-4-298-b11","series-title":"J Interv Cardiol","first-page":"43","article-title":"Patent foramen ovale with paradoxical embolism: mid-term results of transcatheter closure in 256 patients","volume":"16","year":"2003","unstructured":"Onorato\n              E,\n            \n            \n              Melzi\n              G,\n            \n            \n              Casilli\n              F,\n            \n            \n              Pedon\n              L,\n            \n            \n              Rigatelli\n              G,\n            \n            \n              Carrozza\n              A,\n            \n          \n          .\n\t\t\t\t\tPatent foramen ovale with paradoxical embolism: mid-term results of transcatheter closure in 256 patients.\n\t\t\t\t\tJ Interv Cardiol2003;16(1):43\u201350."}],"container-title":["Texas Heart Institute Journal"],"original-title":[],"link":[{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/47\/4\/article-p298.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/thij\/article-pdf\/47\/4\/298\/2778586\/i1526-6702-47-4-298.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/47\/4\/article-p298.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/47\/4\/article-p298.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:36:43Z","timestamp":1730993803000},"score":1,"resource":{"primary":{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/47\/4\/article-p298.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":11,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.14503\/thij-16-6094","relation":{},"ISSN":["0730-2347","1526-6702"],"issn-type":[{"value":"0730-2347","type":"print"},{"value":"1526-6702","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]}}}