{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:10:46Z","timestamp":1782472246845,"version":"3.54.5"},"reference-count":16,"publisher":"Texas Heart Institute Journal","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>The right ventricle provides systemic circulation in individuals with congenitally corrected transposition of the great arteries (CCTGA) and in those with complete transposition who have had an atrial switch repair (DTGA). The aim of this study was to evaluate how the systemic right ventricle adapts to increased workload and oxygen demand during exercise.<\/jats:p>\n        <jats:p>From November 2005 through December 2015, 3,358 adult patients with congenital heart disease were treated at our institution; we identified 48 (26 females, 22 males; median age, 25.4 \u00b1 8.1 yr) who met the study criteria; 37 had DTGA and atrial switch repair, and 11 had CCTGA. We studied their echocardiographic and cardiopulmonary exercise test results. A control group consisted of 29 healthy sex- and age-matched volunteers.<\/jats:p>\n        <jats:p>On exercise testing, oxygen uptake at anaerobic threshold, peak oxygen uptake, peak heart rate, and percentage of maximal heart rate were significantly lower in the group with systemic right ventricle than in the control group (all <jats:italic>P<\/jats:italic> &lt;0.001); in contrast, the peak ventilatory equivalent for carbon dioxide was higher in the study group (<jats:italic>P<\/jats:italic>=0.013). Impaired systemic right ventricular function reduced peak oxygen uptake. The peak heart rate was lower in the CCTGA group than in the DTGA group.<\/jats:p>\n        <jats:p>Our results indicate that reduced exercise capacity is related to impaired systemic right ventricular function, severe tricuspid valve regurgitation, and chronotropic incompetence. There was no correlation between cardiopulmonary exercise test results and time after surgery. Chronotropic efficiency is lower in individuals with CCTGA than in those with DTGA.<\/jats:p>","DOI":"10.14503\/thij-17-6408","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T15:30:55Z","timestamp":1550244655000},"page":"14-20","source":"Crossref","is-referenced-by-count":14,"title":["Clinical Evaluation of Exercise Capacity in Adults with Systemic Right Ventricle"],"prefix":"10.14503","volume":"46","author":[{"given":"Beata","family":"Rog","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"Salapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Okolska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Dluzniewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Werynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Podolec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Tomkiewicz-Pajak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5628","reference":[{"issue":"2","key":"i1526-6702-46-1-14-b1","series-title":"Int J Cardiol","first-page":"141","article-title":"Mechanisms for cardiac output augmentation in patients with a systemic right ventricle","volume":"143","year":"2010","unstructured":"Winter\n              MM\n            , van der PlasMN, BoumaBJ, GroeninkM, BresserP, MulderBJ. \n          Mechanisms for cardiac output augmentation in patients with a systemic right ventricle. Int J Cardiol2010;143(2):141\u20136."},{"issue":"7","key":"i1526-6702-46-1-14-b2","series-title":"J Am Soc Echocardiogr","first-page":"685","article-title":"Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography","volume":"23","year":"2010","unstructured":"Rudski\n              LG\n            , LaiWW, AfilaloJ, HuaL, HandschumacherMD, ChandrasekaranK, \n          et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr2010;23(7):685\u2013713."},{"issue":"3","key":"i1526-6702-46-1-14-b3","series-title":"Eur Heart J Cardiovasc Imaging","first-page":"233","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","year":"2015","unstructured":"Lang\n              RM\n            , BadanoLP, Mor-AviV, AfilaloJ, ArmstrongA, ErnandeL, \n          et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging2015;16(3):233\u201370."},{"issue":"8\u20139","key":"i1526-6702-46-1-14-b4","series-title":"Arch Cardiovasc Dis","first-page":"432","article-title":"The role of echocardiography in the assessment of right ventricular systolic function in patients with transposition of the great arteries and atrial redirection","volume":"105","year":"2012","unstructured":"Iriart\n              X\n            , HorovitzA, van GeldorpIE, BarnetcheT, LederlinM, De GuillebonM, \n          et al. The role of echocardiography in the assessment of right ventricular systolic function in patients with transposition of the great arteries and atrial redirection. Arch Cardiovasc Dis2012;105(8\u20139):432\u201341."},{"issue":"10","key":"i1526-6702-46-1-14-b5","series-title":"Neth Heart J","first-page":"385","article-title":"Cardiopulmonary exercise testing in congenital heart disease: (contra)indications and interpretation","volume":"17","year":"2009","unstructured":"Takken\n              T\n            , BlankAC, HulzebosEH, van BrusselM, GroenWG, HeldersPJ. \n          Cardiopulmonary exercise testing in congenital heart disease: (contra)indications and interpretation. Neth Heart J2009;17(10):385\u201392."},{"issue":"2","key":"i1526-6702-46-1-14-b6","series-title":"Acta Cardiol","first-page":"155","article-title":"Single ventricle function and exercise tolerance in adult patients after Fontan operation","volume":"69","year":"2014","unstructured":"Tomkiewicz-Pajak\n              L\n            , PodolecP, DrabikL, PajakJ, KolczJ, PlazakW. \n          Single ventricle function and exercise tolerance in adult patients after Fontan operation. Acta Cardiol2014;69 (2):155\u201360."},{"issue":"2","key":"i1526-6702-46-1-14-b7","series-title":"Heart","first-page":"191","article-title":"Exercise capacity in adult patients with congenitally corrected transposition of the great arteries","volume":"85","year":"2001","unstructured":"Fredriksen\n              PM\n            , ChenA, VeldtmanG, HechterS, TherrienJ, WebbG. \n          Exercise capacity in adult patients with congenitally corrected transposition of the great arteries. Heart2001;85 (2):191\u20135."},{"issue":"23","key":"i1526-6702-46-1-14-b8","series-title":"J Physiol","first-page":"5039","article-title":"Why right is never left: the systemic right ventricle in transposition of the great arteries","volume":"593","year":"2015","unstructured":"Waterhouse\n              BR\n            , BeraKD. \n          Why right is never left: the systemic right ventricle in transposition of the great arteries. J Physiol2015;593(23):5039\u201341."},{"issue":"6","key":"i1526-6702-46-1-14-b9","series-title":"Heart","first-page":"678","article-title":"Cardiovascular response to physical exercise in adult patients after atrial correction for transposition of the great arteries assessed with magnetic resonance imaging","volume":"90","year":"2004","unstructured":"Roest\n              AA\n            , LambHJ, van der WallEE, VliegenHW, van den AardwegJG, KunzP, \n          et al. Cardiovascular response to physical exercise in adult patients after atrial correction for transposition of the great arteries assessed with magnetic resonance imaging. Heart2004;90(6):678\u201384."},{"issue":"10","key":"i1526-6702-46-1-14-b10","series-title":"Eur Heart J Cardiovasc Imaging","first-page":"963","article-title":"Diffuse myocardial fibrosis in the systemic right ventricle of patients late after Mustard or Senning surgery: an equilibrium contrast cardiovascular magnetic resonance study","volume":"14","year":"2013","unstructured":"Plymen\n              CM\n            , SadoDM, TaylorAM, BolgerAP, LambiasePD, HughesM, MoonJC. \n          Diffuse myocardial fibrosis in the systemic right ventricle of patients late after Mustard or Senning surgery: an equilibrium contrast cardiovascular magnetic resonance study. Eur Heart J Cardiovasc Imaging2013;14 (10):963\u20138."},{"issue":"4","key":"i1526-6702-46-1-14-b11","series-title":"Heart","first-page":"322","article-title":"Myocardial perfusion defects and associated systemic ventricular dysfunction in congenitally corrected transposition of the great arteries","volume":"80","year":"1998","unstructured":"Hornung\n              TS\n            , BernardEJ, JaeggiET, Howman-GilesRB, CelermajerDS, HawkerRE. \n          Myocardial perfusion defects and associated systemic ventricular dysfunction in congenitally corrected transposition of the great arteries. Heart1998;80 (4):322\u20136."},{"issue":"134","key":"i1526-6702-46-1-14-b12","series-title":"Eur Respir Rev","first-page":"476","article-title":"The right ventricle in pulmonary arterial hypertension","volume":"23","year":"2014","unstructured":"Naeije\n              R\n            , ManesA. \n          The right ventricle in pulmonary arterial hypertension. Eur Respir Rev2014;23(134):476\u201387."},{"issue":"Suppl 1","key":"i1526-6702-46-1-14-b13","series-title":"Heart","first-page":"i27","article-title":"The right ventricle in congenital heart disease","volume":"92","year":"2006","unstructured":"Davlouros\n              PA\n            , NiwaK, WebbG, GatzoulisMA. \n          The right ventricle in congenital heart disease. Heart2006;92Suppl 1:i27\u201338."},{"issue":"3","key":"i1526-6702-46-1-14-b14","series-title":"Pediatr Cardiol","first-page":"210","article-title":"Assessment of progressive changes in exercise performance in patients with a systemic right ventricle following the atrial switch repair","volume":"22","year":"2001","unstructured":"Singh\n              TP\n            , WolfeRR, SullivanNM, McCoolP, NeishSR. \n          Assessment of progressive changes in exercise performance in patients with a systemic right ventricle following the atrial switch repair. Pediatr Cardiol2001;22(3):210\u20134."},{"issue":"1","key":"i1526-6702-46-1-14-b15","series-title":"Cardiol J","first-page":"29","article-title":"Factors associated with the presence of tricuspid valve regurgitation in patients with systemic right ventricles following atrial switch","volume":"17","year":"2010","unstructured":"Szymanski\n              P\n            , KlisiewiczA, LubiszewskaB, KonkaM, LipczynskaM, KusmierczykM, HoffmanP. \n          Factors associated with the presence of tricuspid valve regurgitation in patients with systemic right ventricles following atrial switch. Cardiol J2010;17(1):29\u201334."},{"issue":"1","key":"i1526-6702-46-1-14-b16","series-title":"Rev Med Liege","first-page":"16","article-title":"European Society of Cardiology guidelines for the management of complex grown-up congenital heart disease [in French]","volume":"69","year":"2014","unstructured":"Miltner\n              B\n            , LancellottiP, SeghayeMC; European Society of Cardiology. \n          European Society of Cardiology guidelines for the management of complex grown-up congenital heart disease [in French]. Rev Med Liege2014;69(1):16\u201325."}],"container-title":["Texas Heart Institute Journal"],"original-title":[],"link":[{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/46\/1\/article-p14.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/thij\/article-pdf\/46\/1\/14\/1969203\/thij-17-6408.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/46\/1\/article-p14.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/46\/1\/article-p14.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:35:38Z","timestamp":1730993738000},"score":1,"resource":{"primary":{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/46\/1\/article-p14.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":16,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.14503\/thij-17-6408","relation":{},"ISSN":["0730-2347","1526-6702"],"issn-type":[{"value":"0730-2347","type":"print"},{"value":"1526-6702","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}