{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:26:53Z","timestamp":1768278413202,"version":"3.49.0"},"reference-count":14,"publisher":"Texas Heart Institute Journal","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>The platelet aggregation inhibitor ticagrelor, a P2Y<jats:sub>12<\/jats:sub> receptor antagonist, is widely used after angioplasty in patients with acute coronary syndrome. Clinical trial data have shown that it is well tolerated by most patients. We present the case of a 62-year-old woman whose ticagrelor-related asymptomatic and persistent sinus pauses after angioplasty resolved when ticagrelor was replaced with prasugrel.<\/jats:p>","DOI":"10.14503\/thij-17-6554","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T15:59:21Z","timestamp":1572537561000},"page":"203-206","source":"Crossref","is-referenced-by-count":6,"title":["Sinoatrial Arrest Caused by Ticagrelor after Angioplasty in a 62-Year-Old Woman with Acute Coronary Syndrome"],"prefix":"10.14503","volume":"46","author":[{"given":"Fan","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burton V.","family":"Silverstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.","family":"Bray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur C.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"8","key":"i1526-6702-46-3-203-b1","series-title":"Am J Cardiol","first-page":"1005","article-title":"Significance of ventricular pauses of three seconds or more detected on twenty-four-hour Holter recordings","volume":"55","year":"1985","unstructured":"Hilgard\n              J\n            , EzriMD, DenesP.\n          Significance of ventricular pauses of three seconds or more detected on twenty-four-hour Holter recordings. Am J Cardiol1985;55(8):1005\u20138."},{"issue":"3","key":"i1526-6702-46-3-203-b2","series-title":"Am J Cardiol","first-page":"390","article-title":"Arrhythmias documented by 24 hour continuous electrocardiographic monitoring in 50 male medical students without apparent heart disease","volume":"39","year":"1977","unstructured":"Brodsky\n              M\n            , WuD, DenesP, KanakisC, RosenKM.\n          Arrhythmias documented by 24 hour continuous electrocardiographic monitoring in 50 male medical students without apparent heart disease. Am J Cardiol1977;39(3):390\u20135."},{"issue":"4","key":"i1526-6702-46-3-203-b3","series-title":"Am Heart J","first-page":"1119","article-title":"Normal sinus heart rate: sinus tachycardia and sinus bradycardia redefined","volume":"124","year":"1992","unstructured":"Spodick\n              DH.\n            \n          \n          Normal sinus heart rate: sinus tachycardia and sinus bradycardia redefined. Am Heart J1992;124(4):1119\u201321."},{"issue":"3","key":"i1526-6702-46-3-203-b4","series-title":"Crit Care Nurs Clin North Am","first-page":"297","article-title":"Bradyarrhythmias: clinical presentation, diagnosis, and management","volume":"28","year":"2016","unstructured":"Wung\n              SF.\n            \n          \n          Bradyarrhythmias: clinical presentation, diagnosis, and management. Crit Care Nurs Clin North Am2016;28(3):297\u2013308."},{"issue":"10","key":"i1526-6702-46-3-203-b5","series-title":"Am Fam Physician","first-page":"691","article-title":"Sick sinus syndrome: a review","volume":"87","year":"2013","unstructured":"Semelka\n              M\n            , GeraJ, UsmanS.\n          Sick sinus syndrome: a review. Am Fam Physician2013;87(10):691\u20136."},{"issue":"2","key":"i1526-6702-46-3-203-b6","series-title":"Nat Rev Cardiol","first-page":"88","article-title":"Diagnosis, pathophysiology, and management of exercise-induced arrhythmias","volume":"14","year":"2017","unstructured":"Guasch\n              E\n            , MontL.\n          Diagnosis, pathophysiology, and management of exercise-induced arrhythmias. Nat Rev Cardiol2017;14(2):88\u2013101."},{"issue":"25","key":"i1526-6702-46-3-203-b7","series-title":"Circulation","first-page":"e344","article-title":"2014 AHA\/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines [published errata appear in Circulation 2014;130 (25):e431\u20134]","volume":"130","year":"2014","unstructured":"Amsterdam\n              EA\n            , WengerNK, BrindisRG, CaseyDEJr, GaniatsTG, HolmesDRJr, \n          et al. 2014 AHA\/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines [published errata appear in Circulation 2014;130 (25):e431\u20134]. Circulation2014;130(25):e344\u2013426."},{"issue":"19","key":"i1526-6702-46-3-203-b8","series-title":"J Am Coll Cardiol","first-page":"1852","article-title":"Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes","volume":"50","year":"2007","unstructured":"Storey\n              RF\n            , HustedS, HarringtonRA, HeptinstallS, WilcoxRG, PetersG, \n          et al. Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes. J Am Coll Cardiol2007;50(19):1852\u20136."},{"issue":"11","key":"i1526-6702-46-3-203-b9","series-title":"N Engl J Med","first-page":"1045","article-title":"Ticagrelor versus clopidogrel in patients with acute coronary syndromes","volume":"361","year":"2009","unstructured":"Wallentin\n              L\n            , BeckerRC, BudajA, CannonCP, EmanuelssonH, HeldC, \n          et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med2009;361(11):1045\u201357."},{"issue":"12","key":"i1526-6702-46-3-203-b10","series-title":"Pharmacoepidemiol Drug Saf","first-page":"1281","article-title":"Ticagrelor and bradycardia: a nested case-control study","volume":"24","year":"2015","unstructured":"Turgeon\n              RD\n            , FernandesKA, JuurlinkD, TuJV, MamdaniM.\n          Ticagrelor and bradycardia: a nested case-control study. Pharmacoepidemiol Drug Saf2015;24(12):1281\u20135."},{"issue":"4","key":"i1526-6702-46-3-203-b11","series-title":"Br J Clin Pharmacol","first-page":"647","article-title":"Antiplatelet therapy: ADP receptor antagonists","volume":"72","year":"2011","unstructured":"Wijeyeratne\n              YD\n            , HeptinstallS.\n          Antiplatelet therapy: ADP receptor antagonists. Br J Clin Pharmacol2011;72(4):647\u201357."},{"issue":"18","key":"i1526-6702-46-3-203-b12","series-title":"J Am Coll Cardiol","first-page":"1456","article-title":"Inhibitory effects of ticagrelor compared with clopidogrel on platelet function in patients with acute coronary syndromes: the PLATO (PLATelet inhibition and patient Outcomes) PLATELET substudy","volume":"56","year":"2010","unstructured":"Storey\n              RF\n            , AngiolilloDJ, PatilSB, DesaiB, EcobR, HustedS, \n          et al. Inhibitory effects of ticagrelor compared with clopidogrel on platelet function in patients with acute coronary syndromes: the PLATO (PLATelet inhibition and patient Outcomes) PLATELET substudy. J Am Coll Cardiol2010;56(18):1456\u201362."},{"issue":"19","key":"i1526-6702-46-3-203-b13","series-title":"J Am Coll Cardiol","first-page":"1908","article-title":"The incidence of bradyarrhythmias and clinical bradyarrhythmic events in patients with acute coronary syndromes treated with ticagrelor or clopidogrel in the PLATO (Platelet Inhibition and Patient Outcomes) trial: results of the continuous electrocardiographic assessment substudy","volume":"57","year":"2011","unstructured":"Scirica\n              BM\n            , CannonCP, EmanuelssonH, MichelsonEL, HarringtonRA, HustedS, \n          et al. The incidence of bradyarrhythmias and clinical bradyarrhythmic events in patients with acute coronary syndromes treated with ticagrelor or clopidogrel in the PLATO (Platelet Inhibition and Patient Outcomes) trial: results of the continuous electrocardiographic assessment substudy. J Am Coll Cardiol2011;57(19):1908\u201316."},{"issue":"9","key":"i1526-6702-46-3-203-b14","series-title":"J Am Coll Cardiol","first-page":"872","article-title":"Ticagrelor increases adenosine plasma concentration in patients with an acute coronary syndrome","volume":"63","year":"2014","unstructured":"Bonello\n              L\n            , LaineM, KipsonN, ManciniJ, HelalO, FromonotJ, \n          et al. Ticagrelor increases adenosine plasma concentration in patients with an acute coronary syndrome. J Am Coll Cardiol2014;63(9):872\u20137."}],"container-title":["Texas Heart Institute Journal"],"original-title":[],"link":[{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/46\/3\/article-p203.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/thij\/article-pdf\/46\/3\/203\/2445215\/thij-17-6554.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/46\/3\/article-p203.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/46\/3\/article-p203.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:35:57Z","timestamp":1730993757000},"score":1,"resource":{"primary":{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/46\/3\/article-p203.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":14,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.14503\/thij-17-6554","relation":{},"ISSN":["0730-2347","1526-6702"],"issn-type":[{"value":"0730-2347","type":"print"},{"value":"1526-6702","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6]]}}}