{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:19:26Z","timestamp":1792174766989,"version":"4.4.0"},"reference-count":10,"publisher":"Texas Heart Institute Journal","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4]]},"abstract":"Zinc, an essential micronutrient, affects the heart by modulating cardiomyocyte oxidative stress and maintaining myocardial structure, among other mechanisms. In cross-sectional studies, patients with heart failure have often had zinc deficiencies, suggesting effects on the ongoing pathogenesis of heart failure. Low plasma and myocardial zinc levels may cause reversible cardiomyopathy in patients who have nutritional deficiencies.<\/jats:p>\n We present the case of a 24-year-old woman with anorexia nervosa and new-onset heart failure whose depressed left ventricular systolic function improved after zinc supplementation. To our knowledge, this is the first report of low plasma zinc levels as the chief cause of cardiomyopathy that resolved after zinc supplementation.<\/jats:p>","DOI":"10.14503\/thij-17-6586","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T19:58:20Z","timestamp":1593547100000},"page":"152-154","source":"Crossref","is-referenced-by-count":20,"title":["Zinc Deficiency as a Reversible Cause of Heart Failure"],"prefix":"10.14503","volume":"47","author":[{"given":"Hannah","family":"Rosenblum","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology, New York-Presbyterian\/Columbia University Irving Medical Center, New York, New York 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnood","family":"Bikdeli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, New York-Presbyterian\/Columbia University Irving Medical Center, New York, New York 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Wessler","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, New York-Presbyterian\/Columbia University Irving Medical Center, New York, New York 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aakriti","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, New York-Presbyterian\/Columbia University Irving Medical Center, New York, New York 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Louis","family":"Jacoby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5628","reference":[{"issue":"2","key":"i1526-6702-47-2-152-b1","series-title":"Biol Trace Elem Res","first-page":"116","article-title":"Serum zinc and copper levels in ischemic cardiomyopathy","volume":"127","year":"2009","unstructured":"Shokrzadeh\n M,\n \n \n Ghaemian\n A,\n \n \n Salehifar\n E,\n \n \n Aliakbari\n S,\n \n \n Saravi\n SS,\n \n \n Ebrahimi\n P.\n \n \n Serum zinc and copper levels in ischemic cardiomyopathy.\n\t\t\t\t\tBiol Trace Elem Res2009;127(2):116\u201323."},{"issue":"11\u201312","key":"i1526-6702-47-2-152-b2","series-title":"Minerva Med","first-page":"397","article-title":"Are failured cardiomyopathies a zinc-deficit related disease? A study on Zn and Cu in patients with chronic failured dilated and hypertrophic cardiomyopathies","volume":"89","year":"1998","unstructured":"Ripa\n S,\n \n \n Ripa\n R,\n \n \n Giustiniani\n S.\n \n \n Are failured cardiomyopathies a zinc-deficit related disease? A study on Zn and Cu in patients with chronic failured dilated and hypertrophic cardiomyopathies.\n\t\t\t\t\tMinerva Med1998;89(11\u201312):397\u2013403."},{"issue":"1","key":"i1526-6702-47-2-152-b3","series-title":"Biol Trace Elem Res","first-page":"11","article-title":"Concentrations of copper, zinc, and magnesium in sera from patients with idiopathic dilated cardiomyopathy","volume":"95","year":"2003","unstructured":"Topuzoglu\n G,\n \n \n Erbay\n AR,\n \n \n Karul\n AB,\n \n \n Yensel\n N.\n \n \n Concentrations of copper, zinc, and magnesium in sera from patients with idiopathic dilated cardiomyopathy.\n\t\t\t\t\tBiol Trace Elem Res2003;95(1):11\u20137."},{"issue":"2","key":"i1526-6702-47-2-152-b4","series-title":"Clin Chim Acta","first-page":"209","article-title":"Trace element concentrations (Cu, Zn, Fe) in sera from patients with dilated cardiomyopathy","volume":"214","year":"1993","unstructured":"Oster\n O.\n \n \n Trace element concentrations (Cu, Zn, Fe) in sera from patients with dilated cardiomyopathy.\n\t\t\t\t\tClin Chim Acta1993;214(2):209\u201318."},{"issue":"3","key":"i1526-6702-47-2-152-b5","series-title":"Biol Trace Elem Res","first-page":"1239","article-title":"Zinc and copper levels in severe heart failure and the effects of atrial fibrillation on the zinc and copper status","volume":"143","year":"2011","unstructured":"Ghaemian\n A,\n \n \n Salehifar\n E,\n \n \n Jalalian\n R,\n \n \n Ghasemi\n F,\n \n \n Azizi\n S,\n \n \n Masoumi\n S,\n \n \n et al.\n Zinc and copper levels in severe heart failure and the effects of atrial fibrillation on the zinc and copper status.\n\t\t\t\t\tBiol Trace Elem Res2011;143(3):1239\u201346."},{"issue":"2","key":"i1526-6702-47-2-152-b6","series-title":"Eur J Heart Fail","first-page":"202","article-title":"Selenium- and zinc-deficient cardiomyopathy in human intestinal malabsorption: preliminary results of selenium\/zinc infusion","volume":"14","year":"2012","unstructured":"Frustaci\n A,\n \n \n Sabbioni\n E,\n \n \n Fortaner\n S,\n \n \n Farina\n M,\n \n \n del Torchio\n R,\n \n \n Tafani\n M,\n \n \n et al.\n Selenium- and zinc-deficient cardiomyopathy in human intestinal malabsorption: preliminary results of selenium\/zinc infusion.\n\t\t\t\t\tEur J Heart Fail2012;14(2):202\u201310."},{"issue":"3","key":"i1526-6702-47-2-152-b7","series-title":"Cardiovasc Res","first-page":"500","article-title":"Macro-and micronutrient dyshomeostasis in the adverse structural remodelling of myocardium","volume":"81","year":"2009","unstructured":"Weber\n KT,\n \n \n Weglicki\n WB,\n \n \n Simpson\n RU.\n \n \n Macro-and micronutrient dyshomeostasis in the adverse structural remodelling of myocardium.\n\t\t\t\t\tCardiovasc Res2009;81(3):500\u20138."},{"issue":"4","key":"i1526-6702-47-2-152-b8","series-title":"J Cardiovasc Pharmacol","first-page":"393","article-title":"Zinc and the prooxidant heart failure phenotype","volume":"64","year":"2014","unstructured":"Efeovbokhan\n N,\n \n \n Bhattacharya\n SK,\n \n \n Ahokas\n RA,\n \n \n Sun\n Y,\n \n \n Guntaka\n RV,\n \n \n Gerling\n IC,\n \n \n Weber\n KT.\n \n \n Zinc and the prooxidant heart failure phenotype.\n\t\t\t\t\tJ Cardiovasc Pharmacol2014;64(4):393\u2013400."},{"issue":"2","key":"i1526-6702-47-2-152-b9","series-title":"Can J Cardiol","first-page":"47","article-title":"A relative deficit in antioxidant reserve may contribute in cardiac failure","volume":"6","year":"1990","unstructured":"Singal\n PK,\n \n \n Kirshenbaum\n LA.\n \n \n A relative deficit in antioxidant reserve may contribute in cardiac failure.\n\t\t\t\t\tCan J Cardiol1990;6(2):47\u20139."},{"issue":"6","key":"i1526-6702-47-2-152-b10","series-title":"J Acad Nutr Diet","first-page":"870","article-title":"The role of micronutrients in heart failure","volume":"112","year":"2012","unstructured":"McKeag\n NA,\n \n \n McKinley\n MC,\n \n \n Woodside\n JV,\n \n \n Harbinson\n MT,\n \n \n McKeown\n PP.\n \n \n The role of micronutrients in heart failure.\n\t\t\t\t\tJ Acad Nutr Diet2012;112(6):870\u201386."}],"container-title":["Texas Heart Institute 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