{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:53:35Z","timestamp":1766087615307,"version":"3.28.0"},"reference-count":12,"publisher":"Texas Heart Institute Journal","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>Influenza causes cardiac and pulmonary complications that can lead to death. Its effect on the conduction system, first described a century ago, has long been thought to be fairly benign. We report 2 cases of high-grade atrioventricular block associated with acute influenza infection. Both patients\u2014a 50-year-old woman with no history of cardiac disease or conduction abnormalities and a 20-year-old man with a history of complex congenital heart disease and conduction abnormalities\u2014received a permanent pacemaker. In the first case, pacemaker interrogation at 4 months revealed persistent atrioventricular block. In the second case, pacemaker interrogation at 3 months suggested resolution. Whether such influenza-associated changes are transient or permanent remains unknown. We recommend keeping a careful watch on influenza patients with cardiac rhythm abnormalities and monitoring them closely to see if the problem resolves.<\/jats:p>","DOI":"10.14503\/thij-18-6658","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T23:58:24Z","timestamp":1601510304000},"page":"220-223","source":"Crossref","is-referenced-by-count":8,"title":["High-Grade Atrioventricular Block Associated With Acute Influenza"],"prefix":"10.14503","volume":"47","author":[{"given":"Kevin","family":"Ergle","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida 32608"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janelle Y.","family":"Gooden","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida 32608"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa M.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida 32608"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"22","key":"i1526-6702-47-3-220-b1","series-title":"Circulation","first-page":"2730","article-title":"Influenza and cardiovascular disease: a new opportunity for prevention and the need for further studies","volume":"108","year":"2003","unstructured":"Madjid\n              M,\n            \n            \n              Naghavi\n              M,\n            \n            \n              Litovsky\n              S,\n            \n            \n              Casscells\n              SW.\n            \n          \n          Influenza and cardiovascular disease: a new opportunity for prevention and the need for further studies.\n\t\t\t\t\tCirculation2003;108(22):2730\u20136."},{"issue":"4 Suppl","key":"i1526-6702-47-3-220-b2","series-title":"Crit Care Med","first-page":"e91","article-title":"Complications of seasonal and pandemic influenza","volume":"38","year":"2010","unstructured":"Rothberg\n              MB,\n            \n            \n              Haessler\n              SD.\n            \n          \n          Complications of seasonal and pandemic influenza.\n\t\t\t\t\tCrit Care Med2010;38(4 Suppl):e91\u2013e7."},{"issue":"48","key":"i1526-6702-47-3-220-b3","series-title":"QJM","first-page":"409","article-title":"Heart-block and bradycardia following influenza","volume":"os-12","year":"1919","unstructured":"Cockayne\n              EA.\n            \n          \n          Heart-block and bradycardia following influenza.\n\t\t\t\t\tQJM1919;os-12(48):409\u201313."},{"issue":"3","key":"i1526-6702-47-3-220-b4","series-title":"Clin Infect Dis","first-page":"415","article-title":"Cardiac findings during uncomplicated acute influenza in ambulatory adults","volume":"40","year":"2005","unstructured":"Ison\n              MG,\n     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Perinatol","first-page":"298","article-title":"Antenatal diagnosis of a foetal heart block in the 33. week of pregnancy [in German]","volume":"181","year":"1977","unstructured":"Methfessel\n              G,\n            \n            \n              Methfessel\n              HD,\n            \n            \n              Wagner\n              G.\n            \n          \n          Antenatal diagnosis of a foetal heart block in the 33. week of pregnancy [in German].\n\t\t\t\t\tZ Geburtshilfe Perinatol1977;181(4):298\u2013301."},{"issue":"6","key":"i1526-6702-47-3-220-b7","series-title":"J Cardiovasc Electrophysiol","first-page":"711","article-title":"H1N1 influenza A virus induced atrioventricular block","volume":"22","year":"2011","unstructured":"Beinart\n              R,\n            \n            \n              Morganti\n              K,\n            \n            \n              Ruskin\n              J,\n            \n            \n              Mela\n              T.\n            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bradycardia","volume":"14","year":"2010","unstructured":"Karplus\n              R,\n            \n            \n              Sanset\n              S,\n            \n            \n              Zaidenstein\n              R,\n            \n            \n              Schneider\n              D,\n            \n            \n              Berkovitch\n              M.\n            \n          \n          Suspected oseltamivir-induced bradycardia.\n\t\t\t\t\tInt J Infect Dis2010;14(Suppl 3):e374\u2013e5."},{"issue":"8 Suppl","key":"i1526-6702-47-3-220-b10","series-title":"Am J Cardiol","first-page":"e95","article-title":"Extreme bradycardia (standstill) case due to oseltamivir use (a rare side effect)","volume":"119","year":"2017","unstructured":"Sagcan\n              A,\n            \n            \n              Tumuklu\n              MM,\n            \n            \n              Sekuri\n              C,\n            \n            \n              Sagcan\n              M,\n            \n   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influenza A virus infection","volume":"74","year":"2011","unstructured":"Lee\n              CY,\n            \n            \n              Wu\n              MC,\n            \n            \n              Chen\n              PY,\n            \n            \n              Chou\n              TY,\n            \n            \n              Chan\n              YJ.\n            \n          \n          Acute immune thrombocytopenic purpura in an adolescent with 2009 novel H1N1 influenza A virus infection.\n\t\t\t\t\tJ Chin Med Assoc2011;74(9):425\u20137."}],"container-title":["Texas Heart Institute 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