{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:57:45Z","timestamp":1790236665055,"version":"4.1.0"},"reference-count":12,"publisher":"Texas Heart Institute Journal","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Cardiac involvement in familial amyloid polyneuropathy consists of arrhythmias, conduction disturbances, and heart failure. To our knowledge, heart rupture has never been described in association with this condition.<\/jats:p>\n        <jats:p>We report the case of a 62-year-old man with a 6-year history of refractory familial amyloid polyneuropathy who underwent liver transplantation. The operation was complicated by severe hypotension because the neuropathy involved the autonomic system. Perioperatively, the patient had a myocardial infarction, and during the next 10 days, a complete interventricular septal rupture developed, resulting in a systemic-to-pulmonary shunt. Coronary angiographic findings were normal. However, the shunt caused unstable hemodynamics, resulting in cardiogenic shock. An attempt to close the rupture percutaneously failed. The patient underwent successful heart transplantation 50 days later.<\/jats:p>\n        <jats:p>Macroscopic examination of the explanted heart showed thickening of both ventricles, septal rupture, and a gray scar in the interventricular septum around the cavity. Histopathologic examination revealed intramural amyloid angiopathy.<\/jats:p>\n        <jats:p>Our case shows that heart rupture can occur in patients with familial amyloid polyneuropathy who have no history of obstructive coronary artery disease, perhaps as a result of tissue fragility caused by amyloid angiopathy. Therefore, autonomic disturbances should be regarded with concern and promptly treated in the perioperative period.<\/jats:p>","DOI":"10.14503\/thij-18-6799","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T23:30:06Z","timestamp":1611185406000},"page":"302-305","source":"Crossref","is-referenced-by-count":1,"title":["Interventricular Septal Rupture in a 62-Year-Old Man With Familial Amyloid Polyneuropathy"],"prefix":"10.14503","volume":"47","author":[{"given":"Stefano","family":"Pidello","sequence":"first","affiliation":[{"name":"Division of Cardiology, Citt\u00e0 della Salute e della Scienza, University Hospital of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Simonato","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Citt\u00e0 della Salute e della Scienza, University Hospital of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Orzan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Citt\u00e0 della Salute e della Scienza, University Hospital of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Frea","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Citt\u00e0 della Salute e della Scienza, University Hospital of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Barreca","sequence":"additional","affiliation":[{"name":"Division of Pathology, Citt\u00e0 della Salute e della Scienza, University Hospital of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Citt\u00e0 della Salute e della Scienza, University Hospital of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Boffini","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Citt\u00e0 della Salute e della Scienza, University Hospital of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5628","reference":[{"issue":"2","key":"i1526-6702-47-4-302-b1","series-title":"Heart Fail Rev","first-page":"163","article-title":"Natural history and therapy of TTR-cardiac amyloidosis: emerging disease-modifying therapies from organ transplantation to stabilizer and silencer drugs","volume":"20","year":"2015","unstructured":"Castano\n              A,\n            \n            \n              Drachman\n              BM,\n            \n            \n              Judge\n              D,\n            \n            \n              Maurer\n              MS.\n            \n          \n          Natural history and therapy of TTR-cardiac amyloidosis: emerging disease-modifying therapies from organ transplantation to stabilizer and silencer drugs.\n\t\t\t\t\tHeart Fail Rev2015;20(2):163\u201378."},{"issue":"10","key":"i1526-6702-47-4-302-b2","series-title":"Clin Cardiol","first-page":"729","article-title":"Left ventricular free wall rupture following acute myocardial infarction and cardiac amyloid","volume":"13","year":"1990","unstructured":"Shirani\n              J,\n            \n            \n              Bonin\n              MA,\n            \n            \n              Gould\n              N,\n            \n            \n              Silver\n              MA.\n            \n          \n          Left ventricular free wall rupture following acute myocardial infarction and cardiac amyloid.\n\t\t\t\t\tClin Cardiol1990;13(10):729\u201331."},{"issue":"3","key":"i1526-6702-47-4-302-b3","series-title":"Anesthesiology","first-page":"873","article-title":"Fatal perioperative myocardial infarction in four patients with cardiac amyloidosis","volume":"92","year":"2000","unstructured":"Kotani\n              N,\n            \n            \n              Hashimoto\n              H,\n            \n            \n              Muraoka\n              M,\n            \n            \n              Kabara\n              S,\n            \n            \n              Okawa\n              H,\n            \n            \n              Matsuki\n              A.\n            \n          \n          Fatal perioperative myocardial infarction in four patients with cardiac amyloidosis.\n\t\t\t\t\tAnesthesiology2000;92(3):873\u20135."},{"issue":"3","key":"i1526-6702-47-4-302-b4","series-title":"Amyloid","first-page":"160","article-title":"Myocardial infarction with \u201cclean coronaries\u201d caused by amyloid light-chain AL amyloidosis: a case report and literature review","volume":"18","year":"2011","unstructured":"Tsai\n              SB,\n            \n            \n              Seldin\n              DC,\n            \n            \n              Wu\n              H,\n            \n            \n              O'Hara\n              C,\n            \n            \n              Ruberg\n              FL,\n            \n            \n              Sanchorawala\n              V.\n            \n          \n          Myocardial infarction with \u201cclean coronaries\u201d caused by amyloid light-chain AL amyloidosis: a case report and literature review.\n\t\t\t\t\tAmyloid2011;18(3):160\u20134."},{"issue":"10","key":"i1526-6702-47-4-302-b5","series-title":"JAMA","first-page":"1322","article-title":"Bleeding manifestations in 100 patients with amyloidosis","volume":"249","year":"1983","unstructured":"Yood\n              RA,\n            \n            \n              Skinner\n              M,\n            \n            \n              Rubinow\n              A,\n            \n            \n              Talarico\n              L,\n            \n            \n              Cohen\n              AS.\n            \n          \n          Bleeding manifestations in 100 patients with amyloidosis.\n\t\t\t\t\tJAMA1983;249(10):1322\u20134."},{"issue":"6","key":"i1526-6702-47-4-302-b6","series-title":"Ann Thorac Surg","first-page":"2132","article-title":"Spontaneous intramural left atrial hematoma associated with systemic amyloidosis","volume":"72","year":"2001","unstructured":"Watanabe\n              K,\n            \n            \n              Miguel\n              B,\n            \n            \n              Kemeny\n              JL,\n            \n            \n              Citron\n              B,\n            \n            \n              Camilleri\n              LF.\n            \n          \n          Spontaneous intramural left atrial hematoma associated with systemic amyloidosis.\n\t\t\t\t\tAnn Thorac Surg2001;72(6):2132\u20134."},{"issue":"4","key":"i1526-6702-47-4-302-b7","series-title":"Amyloid","first-page":"221","article-title":"Spontaneous pericardial hematoma with familial amyloid polyneuropathy","volume":"16","year":"2009","unstructured":"Nakanishi\n              N,\n            \n            \n              Sawada\n              T,\n            \n            \n              Sato\n              R,\n            \n            \n              Yanishi\n              K,\n            \n            \n              Akakabe\n              Y,\n            \n            \n              Nishizawa\n              S,\n            \n          \n          .\n\t\t\t\t\tSpontaneous pericardial hematoma with familial amyloid polyneuropathy.\n\t\t\t\t\tAmyloid2009;16(4):221\u20135."},{"issue":"4","key":"i1526-6702-47-4-302-b8","series-title":"Eur J Echocardiogr","first-page":"585","article-title":"Intramyocardial dissecting haematoma: a rare complication of acute myocardial infarction","volume":"10","year":"2009","unstructured":"Dias\n              V,\n            \n            \n              Cabral\n              S,\n            \n            \n              Gomes\n              C,\n            \n            \n              Antunes\n              N,\n            \n            \n              Sousa\n              C,\n            \n            \n              Vieira\n              M,\n            \n          \n          .\n\t\t\t\t\tIntramyocardial dissecting haematoma: a rare complication of acute myocardial infarction.\n\t\t\t\t\tEur J Echocardiogr2009;10(4):585\u20137."},{"issue":"7","key":"i1526-6702-47-4-302-b9","series-title":"J Geriatr Cardiol","first-page":"632","article-title":"Intramyocardial dissection with concomitant left ventricular aneurysm as a rare complication of myocardial infarction: a case report","volume":"13","year":"2016","unstructured":"Liu\n              CC,\n            \n            \n              Wang\n              LS,\n            \n            \n              Su\n              ZP,\n            \n            \n              Zhao\n              Y,\n            \n            \n              Gu\n              CX.\n            \n          \n          Intramyocardial dissection with concomitant left ventricular aneurysm as a rare complication of myocardial infarction: a case report.\n\t\t\t\t\tJ Geriatr Cardiol2016;13(7):632\u20135."},{"issue":"5","key":"i1526-6702-47-4-302-b10","series-title":"Circ J","first-page":"530","article-title":"Serum amyloid A protein as a predictor of cardiac rupture in acute myocardial infarction patients following primary coronary angioplasty","volume":"70","year":"2006","unstructured":"Katayama\n              T,\n            \n            \n              Nakashima\n              H,\n            \n            \n              Takagi\n              C,\n            \n            \n              Honda\n              Y,\n            \n            \n              Suzuki\n              S,\n            \n            \n              Iwasaki\n              Y,\n            \n          \n          .\n\t\t\t\t\tSerum amyloid A protein as a predictor of cardiac rupture in acute myocardial infarction patients following primary coronary angioplasty.\n\t\t\t\t\tCirc J2006;70(5):530\u20135."},{"issue":"24","key":"i1526-6702-47-4-302-b11","series-title":"Circulation","first-page":"2911","article-title":"Myocardial muscarinic receptor upregulation and normal response to isoproterenol in denervated hearts by familial amyloid polyneuropathy","volume":"104","year":"2001","unstructured":"Delahaye\n              N,\n            \n            \n              Le Guludec\n              D,\n            \n            \n              Dinanian\n              S,\n            \n            \n              Delforge\n              J,\n            \n            \n              Slama\n              MS,\n            \n            \n              Sarda\n              L,\n            \n          \n          .\n\t\t\t\t\tMyocardial muscarinic receptor upregulation and normal response to isoproterenol in denervated hearts by familial amyloid polyneuropathy.\n\t\t\t\t\tCirculation2001;104(24):2911\u20136."},{"issue":"7\u20138","key":"i1526-6702-47-4-302-b12","series-title":"Rev Port Cardiol","first-page":"689","article-title":"Haemodynamics during liver transplantation in familial amyloidotic polyneuropathy: study of the intraoperative cardiocirculatory data of 50 patients","volume":"18","year":"1999","unstructured":"da Silva Viana\n              J,\n            \n            \n              Bento\n              C,\n            \n            \n              Vieira\n              H,\n            \n            \n              Neves\n              S,\n            \n            \n              Seco\n              C,\n            \n            \n              Elvas\n              L,\n            \n          \n          .\n\t\t\t\t\tHaemodynamics during liver transplantation in familial amyloidotic polyneuropathy: study of the intraoperative cardiocirculatory data of 50 patients.\n\t\t\t\t\tRev Port Cardiol1999;18(7\u20138):689\u201397."}],"container-title":["Texas Heart Institute Journal"],"original-title":[],"link":[{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/47\/4\/article-p302.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/meridian.allenpress.com\/thij\/article-pdf\/47\/4\/302\/2778569\/i1526-6702-47-4-302.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/47\/4\/article-p302.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/47\/4\/article-p302.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:37:17Z","timestamp":1730993837000},"score":1,"resource":{"primary":{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/47\/4\/article-p302.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":12,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.14503\/thij-18-6799","relation":{},"ISSN":["0730-2347","1526-6702"],"issn-type":[{"value":"0730-2347","type":"print"},{"value":"1526-6702","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]}}}