{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:24:11Z","timestamp":1791483851505,"version":"4.3.4"},"reference-count":30,"publisher":"Texas Heart Institute Journal","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>To investigate whether transcatheter device closure of patent ductus arteriosus (PDA) is safe in children with pulmonary artery hypertension, we retrospectively analyzed our experience with 33 patients who underwent the procedure from January 2000 through August 2015.<\/jats:p>\n        <jats:p>Pulmonary artery hypertension was defined as a pulmonary vascular resistance index (PVRI) &gt;3 WU \u00b7 m<jats:sup>2<\/jats:sup>. All 33 children (median age, 14.5 mo; median weight, 8.1 kg) underwent successful closure device implantation and were followed up for a median of 17.2 months (interquartile range [IQR], 1.0\u201363.4 mo). During catheterization, the median PVRI was 4.1 WU \u00b7 m<jats:sup>2<\/jats:sup> (IQR, 3.6\u20135.3 WU \u00b7 m<jats:sup>2<\/jats:sup>), and the median mean pulmonary artery pressure was 38.0 mmHg (IQR, 25.5\u201346.0 mmHg). Premature birth was associated with pulmonary vasodilator therapy at time of PDA closure ( <jats:italic>P<\/jats:italic>=0.001) but not with baseline PVRI (<jats:italic>P<\/jats:italic>=0.986). Three patients (9.1%) had device-related complications (one immediate embolization and 2 malpositions). Two of these complications involved embolization coils. Baseline pulmonary vasodilator therapy before closure was significantly associated with intensive care unit admission after closure (10\/12 [83.3%] with baseline therapy vs 3\/21 [14.3%] without; <jats:italic>P<\/jats:italic> &lt;0.001). Of 11 patients receiving pulmonary vasodilators before closure and having a device in place long-term, 8 (72.7%) were weaned after closure (median, 24.0 mo [IQR, 11.0\u201325.0 mo]).<\/jats:p>\n        <jats:p>We conclude that transcatheter PDA closure can be performed safely in many children with pulmonary artery hypertension and improve symptoms, particularly in patients born prematurely. Risk factors for adverse outcomes are multifactorial, including coil use and disease severity. Multicenter studies in larger patient populations are warranted.<\/jats:p>","DOI":"10.14503\/thij-19-6982","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T23:20:24Z","timestamp":1611184824000},"page":"250-257","source":"Crossref","is-referenced-by-count":10,"title":["Safety and Outcomes of Transcatheter Closure of Patent Ductus Arteriosus in Children With Pulmonary Artery Hypertension"],"prefix":"10.14503","volume":"47","author":[{"given":"Arash","family":"Salavitabar","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, New York, 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha S.","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, New York, 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariel E.","family":"Turner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, New York, 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Vincent","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, New York, 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro J.","family":"Torres","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, New York, 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Crystal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, New York, 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5628","reference":[{"issue":"17","key":"i1526-6702-47-4-250-b1","series-title":"Circulation","first-page":"1873","article-title":"Patent ductus arteriosus","volume":"114","year":"2006","unstructured":"Schneider\n              DJ,\n            \n            \n              Moore\n              JW.\n            \n          \n          Patent ductus arteriosus.\n\t\t\t\t\tCirculation2006;114(17):1873\u201382."},{"key":"i1526-6702-47-4-250-b2","series-title":"Moss and Adams' heart disease in infants, children, and adolescents: including the fetus and young adult","first-page":"722","article-title":"Patent ductus arteriosus and aortopulmonary window","year":"2013","unstructured":"Moore\n              P,\n            \n            \n              Brook\n              MM.\n            \n          \n          Patent ductus arteriosus and aortopulmonary window.\n\t\t\t\t\tIn:AllenHD,DriscollDJ,ShaddyRE,FeltesTF,editors.Moss and Adams' heart disease in infants, children, and adolescents: including the fetus and young adult.\n\t\t\t\t\t8th ed.\n\t\t\t\t\tPhiladelphia:\n\t\t\t\t\tLippincott Williams & Wilkins;\n\t\t\t\t\t2013. p.\n\t\t\t\t\t722\u201345."},{"issue":"2","key":"i1526-6702-47-4-250-b3","series-title":"Pediatrics","first-page":"e20162927","article-title":"Percutaneous patent ductus arteriosus (PDA) closure during infancy: a meta-analysis","volume":"139","year":"2017","unstructured":"Backes\n              CH,\n            \n            \n              Rivera\n              BK,\n            \n            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