{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T05:46:32Z","timestamp":1751521592043,"version":"3.28.0"},"reference-count":35,"publisher":"Texas Heart Institute Journal","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Mitochondrial disease comprises a wide range of genetic disorders caused by mitochondrial dysfunction. Its rarity, however, has limited the ability to assess its effects on clinical outcomes. To evaluate this relationship, we collected data from the 2016 National Inpatient Sample, which includes data from &gt;7 million hospital stays. We identified 705 patients (mean age, 22 \u00b1 20.7 yr; 54.2% female; 67.4% white) whose records included the ICD-10-CM code E88.4. We also identified a propensity-matched cohort of 705 patients without mitochondrial disease to examine the effect of mitochondrial disease on major adverse cardiovascular events, including all-cause in-hospital death, cardiac arrest, and acute congestive heart failure.<\/jats:p>\n        <jats:p>Patients with mitochondrial disease were at significantly greater risk of major adverse cardiovascular events (odds ratio [OR]=2.42; 95% CI, 1.29\u20134.57; <jats:italic>P<\/jats:italic>=0.005), systolic heart failure (OR=2.37; 95% CI, 1.08\u20135.22; <jats:italic>P<\/jats:italic>=0.027), and all-cause in-hospital death (OR=14.22; 95% CI, 1.87\u2013108.45; <jats:italic>P<\/jats:italic>&lt;0.001).<\/jats:p>\n        <jats:p>These findings suggest that mitochondrial disease significantly increases the risk of inpatient major adverse cardiovascular events.<\/jats:p>","DOI":"10.14503\/thij-20-7243","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T15:56:55Z","timestamp":1628783815000},"source":"Crossref","is-referenced-by-count":3,"title":["Cardiovascular Outcomes in Patients With Mitochondrial Disease in the United States: A Propensity Score Analysis"],"prefix":"10.14503","volume":"48","author":[{"given":"Tran","family":"Nguyen","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, George Washington University, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talal","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, George Washington University, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Krepp","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, George Washington University, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurusher","family":"Panjrath","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, George Washington University, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"2","key":"i1526-6702-48-3-e207243-b1","series-title":"Am J Hum Genet","first-page":"254","article-title":"Pathogenic mitochondrial DNA mutations are common in the general population","volume":"83","year":"2008","unstructured":"Elliott\n              HR,\n            \n            \n              Samuels\n              DC,\n            \n            \n              Eden\n              JA,\n            \n            \n              Relton\n              CL,\n            \n            \n              Chinnery\n              PF.\n            \n          \n          Pathogenic mitochondrial DNA mutations are common in the general 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disorders","volume":"366","year":"2012","unstructured":"Koopman\n              WJH,\n            \n            \n              Willems\n              PHGM,\n            \n            \n              Smeitink\n              JAM.\n            \n          \n          Monogenic mitochondrial disorders.\n\t\t\t\t\tN Engl J Med2012;366(12):1132\u201341."},{"issue":"5","key":"i1526-6702-48-3-e207243-b5","series-title":"Biochim Biophys Acta","first-page":"619","article-title":"MELAS: a nationwide prospective cohort study of 96 patients in Japan","volume":"1820","year":"2012","unstructured":"Yatsuga\n              S,\n            \n            \n              Povalko\n              N,\n            \n            \n              Nishioka\n              J,\n            \n            \n              Katayama\n              K,\n            \n            \n              Kakimoto\n              N,\n            \n            \n              Matsuishi\n              T,\n            \n          \n        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Mitochondrial dynamics and apoptosis--the ER connection","volume":"337","year":"2012","unstructured":"Hoppins\n              S,\n            \n            \n              Nunnari\n              J.\n            \n          \n          Cell Biology. Mitochondrial dynamics and apoptosis--the ER connection.\n\t\t\t\t\tScience2012;337(6098):1052\u20134."},{"key":"i1526-6702-48-3-e207243-b11","series-title":"Annu Rev Physiol","first-page":"19","article-title":"Cell death in the pathogenesis of heart disease: mechanisms and significance","volume":"72","year":"2010","unstructured":"Whelan\n              RS,\n            \n            \n              Kaplinskiy\n              V,\n            \n            \n              Kitsis\n              RN.\n            \n          \n          Cell death in the pathogenesis of heart disease: mechanisms and significance.\n\t\t\t\t\tAnnu Rev Physiol2010;72:19\u201344."},{"key":"i1526-6702-48-3-e207243-b12","series-title":"BMC Cardiovasc Disord","first-page":"12","article-title":"Cardiac abnormalities in patients with mitochondrial DNA mutation 3243A>G","volume":"2","year":"2002","unstructured":"Majamaa-Voltti\n              K,\n            \n            \n              Peuhkurinen\n              K,\n 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disease.\n\t\t\t\t\tEur J Heart Fail2010;12(2):114\u201321."},{"issue":"4","key":"i1526-6702-48-3-e207243-b15","series-title":"Tex Heart Inst J","first-page":"385","article-title":"Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management","volume":"40","year":"2013","unstructured":"Meyers\n              DE,\n            \n            \n              Basha\n              HI,\n            \n            \n              Koenig\n              MK.\n            \n          \n          Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management.\n\t\t\t\t\tTex Heart Inst J2013;40(4):385\u201394."},{"issue":"3","key":"i1526-6702-48-3-e207243-b16","series-title":"Eur Heart J","first-page":"280","article-title":"Cardiomyopathy in children with mitochondrial disease: clinical course and cardiological findings","volume":"24","year":"2003","unstructured":"Holmgren\n              D,\n            \n            \n              Wahlander\n              H,\n            \n     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p.479\u2013504."},{"issue":"7","key":"i1526-6702-48-3-e207243-b18","series-title":"Heart","first-page":"791","article-title":"Cardiac abnormalities in patients with Leber's hereditary optic neuropathy","volume":"89","year":"2003","unstructured":"Sorajja\n              P,\n            \n            \n              Sweeney\n              MG,\n            \n            \n              Chalmers\n              R,\n            \n            \n              Sachdev\n              B,\n            \n            \n              Syrris\n              P,\n            \n            \n              Hanna\n              M,\n            \n          \n          .\n\t\t\t\t\tCardiac abnormalities in patients with Leber's hereditary optic neuropathy.\n\t\t\t\t\tHeart2003;89(7):791\u20132."},{"issue":"2","key":"i1526-6702-48-3-e207243-b19","series-title":"Am J Cardiol","first-page":"264","article-title":"Cardiac involvement in adults with m.3243A>G MELAS gene mutation","volume":"99","year":"2007","unstructured":"Vydt\n              TCG,\n            \n            \n              de Coo\n              RFM,\n            \n            \n              Soliman\n              OII,\n            \n            \n              Ten Cate\n              FJ,\n            \n            \n              van Geuns\n              RJM,\n            \n            \n              Vletter\n              WB,\n            \n          \n          .\n\t\t\t\t\tCardiac involvement in adults with m.3243A>G MELAS gene mutation.\n\t\t\t\t\tAm J Cardiol2007;99(2):264\u20139."},{"issue":"4","key":"i1526-6702-48-3-e207243-b20","series-title":"Circulation","first-page":"955","article-title":"Cardiac involvement in mitochondrial diseases: a study on 17 patients with documented mitochondrial DNA defects","volume":"91","year":"1995","unstructured":"Anan\n              R,\n            \n            \n              Nakagawa\n              M,\n            \n            \n          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DNA.\n\t\t\t\t\tNeurology2010;74(8):674\u20137."},{"issue":"2","key":"i1526-6702-48-3-e207243-b29","series-title":"J Neurol Sci","first-page":"217","article-title":"Genetic biochemical and pathophysiological characterization of a familial mitochondrial encephalomyopathy (MERRF)","volume":"105","year":"1991","unstructured":"Seibel\n              P,\n            \n            \n              Degoul\n              F,\n            \n            \n              Bonne\n              G,\n            \n            \n              Romero\n              N,\n            \n            \n              Francois\n              D,\n            \n            \n              Paturneau-Jouas\n              M,\n            \n          \n          .\n\t\t\t\t\tGenetic biochemical and pathophysiological characterization of a familial mitochondrial encephalomyopathy (MERRF).\n\t\t\t\t\tJ Neurol Sci1991;105(2):217\u201324."},{"issue":"1","key":"i1526-6702-48-3-e207243-b30","series-title":"Eur Heart 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isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis","volume":"36","year":"2000","unstructured":"Oechslin\n              EN,\n            \n            \n              Attenhofer Jost\n              CH,\n            \n            \n              Rojas\n              JR,\n            \n            \n              Kaufmann\n              PA,\n            \n            \n              Jenni\n              R.\n            \n          \n          Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis.\n\t\t\t\t\tJ Am Coll Cardiol2000;36(2):493\u2013500."},{"issue":"5","key":"i1526-6702-48-3-e207243-b32","series-title":"Pediatr Cardiol","first-page":"659","article-title":"Cardiogenetics, neurogenetics, and pathogenetics of left ventricular hypertrabeculation\/noncompaction","volume":"30","year":"2009","unstructured":"Finsterer\n              J.\n            \n          \n          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Genet","first-page":"333","article-title":"The epidemiology of Leber hereditary optic neuropathy in the North East of England [published erratum appears in Am J Hum Genet 2016;98(6):1271]","volume":"72","year":"2003","unstructured":"Yu-Wai-Man\n              P,\n            \n            \n              Griffiths\n              PG,\n            \n            \n              Brown\n              DT,\n            \n            \n              Howell\n              N,\n            \n            \n              Turnbull\n              DM,\n            \n            \n              Chinnery\n              PF.\n            \n          \n          The epidemiology of Leber hereditary optic neuropathy in the North East of England [published erratum appears in Am J Hum Genet 2016;98(6):1271].\n\t\t\t\t\tAm J Hum Genet2003;72(2):333\u20139."},{"issue":"2","key":"i1526-6702-48-3-e207243-b35","series-title":"Am J Hum Genet","first-page":"447","article-title":"Epidemiology of A3243G, the mutation 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