{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T05:23:22Z","timestamp":1731043402102,"version":"3.28.0"},"reference-count":21,"publisher":"Texas Heart Institute Journal","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"abstract":"Frequent ventricular premature complexes (VPCs) and VPC QRS duration are risk factors for left ventricular (LV) dysfunction. To determine which clinical characteristics and electrocardiographic features are associated with LV dysfunction (ejection fraction, <50%) and frequent VPCs, we retrospectively reviewed data from a single-center registry of all patients diagnosed with frequent VPCs at a Korean outpatient clinic.<\/jats:p>\n We identified 412 consecutive outpatients (mean age, 54.7 \u00b1 16.8 yr; 227 women [55.1%]) who were diagnosed with frequent VPCs and had no structural heart disease from January 2010 through December 2017. Available transthoracic echocardiograms and 24-hour Holter monitoring data were evaluated to correlate the occurrence of VPCs and symptoms.<\/jats:p>\n Typical VPC-related symptoms (palpitations or dropped beats) were observed in 251 patients (61.1%). Electrocardiograms revealed VPCs with a left bundle branch block\u2013like morphology in 327 patients (79.5%) and VPCs with an inferior axis in 353 (85.8%). Twenty-six patients (6.3%) were diagnosed with VPC-related LV dysfunction. The mean VPC burden did not differ significantly by LV functional status (11.06% \u00b1 10.13% [normal] vs 14.41% \u00b1 13.30% [impaired]; P<\/jats:italic>=0.211). Patients with impaired LV function were more often men (P<\/jats:italic>=0.027), had no typical VPC-related symptoms (P<\/jats:italic>=0.006), and had significantly longer VPC QRS durations (mean, 157 ms vs 139 ms; P<\/jats:italic> <0.01).<\/jats:p>\n Our findings suggest that male sex, absence of typical VPC-related symptoms, and a VPC QRS duration >157 ms are associated with LV dysfunction in patients with frequent VPCs, findings that may be useful in predicting such dysfunction.<\/jats:p>","DOI":"10.14503\/thij-20-7265","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T15:06:52Z","timestamp":1646060812000},"source":"Crossref","is-referenced-by-count":0,"title":["Left Ventricular Dysfunction in Outpatients with Frequent Ventricular Premature Complexes"],"prefix":"10.14503","volume":"49","author":[{"given":"Kyoung-Min","family":"Park","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Il","family":"Im","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Bin","family":"Gwag","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngjun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Keun","family":"On","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"2","key":"i1526-6702-49-1-e207265-b1","series-title":"Am J Cardiol","first-page":"151","article-title":"Relation of atrial and\/or ventricular premature complexes on a two-minute rhythm strip to the risk of sudden cardiac death (the Atherosclerosis Risk In Communities [ARIC] study)","volume":"107","year":"2011","unstructured":"Cheriyath\n P,\n \n \n He\n F,\n \n \n Peters\n I,\n \n \n Li\n X,\n \n \n Alagona\n P\n Jr,\n \n \n Wu\n C,\n \n \n .\n\t\t\t\t\tRelation of atrial and\/or ventricular premature complexes on a two-minute rhythm strip to the risk of sudden cardiac death (the Atherosclerosis Risk In Communities [ARIC] study).\n\t\t\t\t\tAm J Cardiol2011;107(2):151\u20135."},{"issue":"3","key":"i1526-6702-49-1-e207265-b2","series-title":"Am Heart J","first-page":"535","article-title":"Prevalence of premature ventricular contractions in a population of African American and white men and women: the Atherosclerosis Risk In Communities (ARIC) study","volume":"143","year":"2002","unstructured":"Simpson\n RJ\n Jr,\n \n \n Cascio\n WE,\n \n \n Schreiner\n PJ,\n \n \n Crow\n RS,\n \n \n Rautaharju\n PM,\n \n \n Heiss\n G.\n \n \n Prevalence of premature ventricular contractions in a population of African American and white men and women: the Atherosclerosis Risk In Communities (ARIC) study.\n\t\t\t\t\tAm Heart J2002;143(3):535\u201340."},{"issue":"3","key":"i1526-6702-49-1-e207265-b3","series-title":"J Cardiovasc Electrophysiol","first-page":"328","article-title":"First evidence of premature ventricular complex\u2013induced cardiomyopathy: a potentially reversible cause of heart failure","volume":"11","year":"2000","unstructured":"Chugh\n SS,\n \n \n Shen\n WK,\n \n \n Luria\n DM,\n \n \n Smith\n HC.\n \n \n First evidence of premature ventricular complex\u2013induced cardiomyopathy: a potentially reversible cause of heart failure.\n\t\t\t\t\tJ Cardiovasc Electrophysiol2000;11(3):328\u20139."},{"issue":"8","key":"i1526-6702-49-1-e207265-b4","series-title":"Am J Cardiol","first-page":"1263","article-title":"Meta-analysis of ventricular premature complexes and their relation to cardiac mortality in general populations","volume":"112","year":"2013","unstructured":"Ataklte\n F,\n \n \n Erqou\n S,\n \n \n Laukkanen\n J,\n \n \n Kaptoge\n S.\n \n \n Meta-analysis of ventricular premature complexes and their relation to cardiac mortality in general populations.\n\t\t\t\t\tAm J Cardiol2013;112(8):1263\u201370."},{"issue":"7","key":"i1526-6702-49-1-e207265-b5","series-title":"Heart Rhythm","first-page":"863","article-title":"Radiofrequency ablation of frequent, idiopathic premature ventricular complexes: comparison with a control group without intervention","volume":"4","year":"2007","unstructured":"Bogun\n F,\n \n \n Crawford\n T,\n \n \n Reich\n S,\n \n \n Koelling\n TM,\n \n \n Armstrong\n W,\n \n \n Good\n E,\n \n \n .\n\t\t\t\t\tRadiofrequency ablation of frequent, idiopathic premature ventricular complexes: comparison with a control group without intervention.\n\t\t\t\t\tHeart Rhythm2007;4(7):863\u20137."},{"issue":"7","key":"i1526-6702-49-1-e207265-b6","series-title":"Heart Rhythm","first-page":"865","article-title":"Relationship between burden of premature ventricular complexes and left ventricular function","volume":"7","year":"2010","unstructured":"Baman\n TS,\n \n \n Lange\n DC,\n \n \n Ilg\n KJ,\n \n \n Gupta\n SK,\n \n \n Liu\n TY,\n \n \n Alguire\n C,\n \n \n .\n\t\t\t\t\tRelationship between burden of premature ventricular complexes and left ventricular function.\n\t\t\t\t\tHeart Rhythm2010;7(7):865\u20139."},{"issue":"9","key":"i1526-6702-49-1-e207265-b7","series-title":"Heart Rhythm","first-page":"1465","article-title":"Predictors of recovery of left ventricular dysfunction after ablation of frequent ventricular premature depolarizations","volume":"9","year":"2012","unstructured":"Deyell\n MW,\n \n \n Park\n KM,\n \n \n Han\n Y,\n \n \n Frankel\n DS,\n \n \n Dixit\n S,\n \n \n Cooper\n JM,\n \n \n .\n\t\t\t\t\tPredictors of recovery of left ventricular dysfunction after ablation of frequent ventricular premature depolarizations.\n\t\t\t\t\tHeart Rhythm2012;9(9):1465\u201372."},{"issue":"2","key":"i1526-6702-49-1-e207265-b8","series-title":"Heart Rhythm","first-page":"299","article-title":"Ventricular premature depolarization QRS duration as a new marker of risk for the development of ventricular premature depolarization\u2013induced cardiomyopathy","volume":"11","year":"2014","unstructured":"Carballeira Pol\n L,\n \n \n Deyell\n MW,\n \n \n Frankel\n DS,\n \n \n Benhayon\n D,\n \n \n Squara\n F,\n \n \n Chik\n W,\n \n \n .\n\t\t\t\t\tVentricular premature depolarization QRS duration as a new marker of risk for the development of ventricular premature depolarization\u2013induced cardiomyopathy.\n\t\t\t\t\tHeart Rhythm2014;11(2):299\u2013306."},{"issue":"12","key":"i1526-6702-49-1-e207265-b9","series-title":"J Am Soc Echocardiogr","first-page":"1440","article-title":"Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology","volume":"18","year":"2005","unstructured":"Lang\n RM,\n \n \n Bierig\n M,\n \n \n Devereux\n RB,\n \n \n Flachskampf\n FA,\n \n \n Foster\n E,\n \n \n Pellikka\n PA,\n \n \n .\n\t\t\t\t\tRecommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology.\n\t\t\t\t\tJ Am Soc Echocardiogr2005;18(12):1440\u201363."},{"issue":"16","key":"i1526-6702-49-1-e207265-b10","series-title":"Circulation","first-page":"1810","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"128","year":"2013","unstructured":"Yancy\n CW,\n \n \n Jessup\n M,\n \n \n Bozkurt\n B,\n \n \n Butler\n J,\n \n \n Casey\n DE\n Jr,\n \n \n Drazner\n MH,\n \n \n .\n\t\t\t\t\t2013 ACCF\/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines.\n\t\t\t\t\tCirculation2013;128(16):1810\u201352."},{"issue":"11","key":"i1526-6702-49-1-e207265-b11","series-title":"J Am Coll Cardiol","first-page":"992","article-title":"AHA\/ACCF\/HRS recommendations for the standardization and interpretation of the electrocardiogram: part V: electrocardiogram changes associated with cardiac chamber hypertrophy: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology","volume":"53","year":"2009","unstructured":"Hancock\n EW,\n \n \n Deal\n BJ,\n \n \n Mirvis\n DM,\n \n \n Okin\n P,\n \n \n Kligfield\n P,\n \n \n Gettes\n LS,\n \n \n .\n\t\t\t\t\tAHA\/ACCF\/HRS recommendations for the standardization and interpretation of the electrocardiogram: part V: electrocardiogram changes associated with cardiac chamber hypertrophy: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Endorsed by the International Society for Computerized Electrocardiology.\n\t\t\t\t\tJ Am Coll Cardiol2009;53(11):992\u20131002."},{"issue":"7","key":"i1526-6702-49-1-e207265-b12","series-title":"J Cardiovasc Electrophysiol","first-page":"791","article-title":"Characteristics of premature ventricular complexes as correlates of reduced left ventricular systolic function: study of the burden, duration, coupling interval, morphology and site of origin of PVCs","volume":"22","year":"2011","unstructured":"Del Carpio Munoz\n F,\n \n \n Syed\n FF,\n \n \n Noheria\n A,\n \n \n Cha\n YM,\n \n \n Friedman\n PA,\n \n \n Hammill\n SC,\n \n \n .\n\t\t\t\t\tCharacteristics of premature ventricular complexes as correlates of reduced left ventricular systolic function: study of the burden, duration, coupling interval, morphology and site of origin of PVCs.\n\t\t\t\t\tJ Cardiovasc Electrophysiol2011;22(7):791\u20138."},{"issue":"9","key":"i1526-6702-49-1-e207265-b13","series-title":"Heart Rhythm","first-page":"1460","article-title":"Impact of QRS duration of frequent premature ventricular complexes on the development of cardiomyopathy","volume":"9","year":"2012","unstructured":"Yokokawa\n M,\n \n \n Kim\n HM,\n \n \n Good\n E,\n \n \n Crawford\n T,\n \n \n Chugh\n A,\n \n \n Pelosi\n F\n Jr,\n \n \n .\n\t\t\t\t\tImpact of QRS duration of frequent premature ventricular complexes on the development of cardiomyopathy.\n\t\t\t\t\tHeart Rhythm2012;9(9):1460\u20134."},{"issue":"5","key":"i1526-6702-49-1-e207265-b14","series-title":"Europace","first-page":"735","article-title":"Electrocardiographic and electrophysiological characteristics of premature ventricular complexes associated with left ventricular dysfunction in patients without structural heart disease","volume":"15","year":"2013","unstructured":"Ban\n JE,\n \n \n Park\n HC,\n \n \n Park\n JS,\n \n \n Nagamoto\n Y,\n \n \n Choi\n JI,\n \n \n Lim\n HE,\n \n \n .\n\t\t\t\t\tElectrocardiographic and electrophysiological characteristics of premature ventricular complexes associated with left ventricular dysfunction in patients without structural heart disease.\n\t\t\t\t\tEuropace2013;15(5):735\u201341."},{"issue":"18","key":"i1526-6702-49-1-e207265-b15","series-title":"Circulation","first-page":"1837","article-title":"Prediction of coronary heart disease using risk factor categories","volume":"97","year":"1998","unstructured":"Wilson\n PW,\n \n \n D'Agostino\n RB,\n \n \n Levy\n D,\n \n \n Belanger\n AM,\n \n \n Silbershatz\n H,\n \n \n Kannel\n WB.\n \n \n Prediction of coronary heart disease using risk factor categories.\n\t\t\t\t\tCirculation1998;97(18):1837\u201347."},{"issue":"2","key":"i1526-6702-49-1-e207265-b16","series-title":"J Am Coll Cardiol","first-page":"231","article-title":"Prognostic significance of ventricular ectopic activity in survivors of acute myocardial infarction","volume":"10","year":"1987","unstructured":"Kostis\n JB,\n \n \n Byington\n R,\n \n \n Friedman\n LM,\n \n \n Goldstein\n S,\n \n \n Furberg\n C.\n \n \n Prognostic significance of ventricular ectopic activity in survivors of acute myocardial infarction.\n\t\t\t\t\tJ Am Coll Cardiol1987;10(2):231\u201342."},{"issue":"6","key":"i1526-6702-49-1-e207265-b17","series-title":"J Cardiovasc Electrophysiol","first-page":"663","article-title":"Tachycardia-induced cardiomyopathy in patients with idiopathic ventricular arrhythmias: the incidence, clinical and electrophysiologic characteristics, and the predictors","volume":"22","year":"2011","unstructured":"Hasdemir\n C,\n \n \n Ulucan\n C,\n \n \n Yavuzgil\n O,\n \n \n Yuksel\n A,\n \n \n Kartal\n Y,\n \n \n Simsek\n E,\n \n \n .\n\t\t\t\t\tTachycardia-induced cardiomyopathy in patients with idiopathic ventricular arrhythmias: the incidence, clinical and electrophysiologic characteristics, and the predictors.\n\t\t\t\t\tJ Cardiovasc Electrophysiol2011;22(6):663\u20138."},{"issue":"1","key":"i1526-6702-49-1-e207265-b18","series-title":"Ann Noninvasive Electrocardiol","first-page":"81","article-title":"Frequent premature ventricular complexes originating from the right ventricular outflow tract are associated with left ventricular dysfunction","volume":"13","year":"2008","unstructured":"Kanei\n Y,\n \n \n Friedman\n M,\n \n \n Ogawa\n N,\n \n \n Hanon\n S,\n \n \n Lam\n P,\n \n \n Schweitzer\n P.\n \n \n Frequent premature ventricular complexes originating from the right ventricular outflow tract are associated with left ventricular dysfunction.\n\t\t\t\t\tAnn Noninvasive Electrocardiol2008;13(1):81\u20135."},{"issue":"8","key":"i1526-6702-49-1-e207265-b19","series-title":"J Am Coll Cardiol","first-page":"1259","article-title":"Radiofrequency catheter ablation of premature ventricular complexes from right ventricular outflow tract improves left ventricular dilation and clinical status in patients without structural heart disease","volume":"45","year":"2005","unstructured":"Takemoto\n M,\n \n \n Yoshimura\n H,\n \n \n Ohba\n Y,\n \n \n Matsumoto\n Y,\n \n \n Yamamoto\n U,\n \n \n Mohri\n M,\n \n \n .\n\t\t\t\t\tRadiofrequency catheter ablation of premature ventricular complexes from right ventricular outflow tract improves left ventricular dilation and clinical status in patients without structural heart disease.\n\t\t\t\t\tJ Am Coll Cardiol2005;45(8):1259\u201365."},{"issue":"15","key":"i1526-6702-49-1-e207265-b20","series-title":"Heart","first-page":"1230","article-title":"Prognostic significance of frequent premature ventricular contractions originating from the ventricular outflow tract in patients with normal left ventricular function","volume":"95","year":"2009","unstructured":"Niwano\n S,\n \n \n Wakisaka\n Y,\n \n \n Niwano\n H,\n \n \n Fukaya\n H,\n \n \n Kurokawa\n S,\n \n \n Kiryu\n M,\n \n \n .\n\t\t\t\t\tPrognostic significance of frequent premature ventricular contractions originating from the ventricular outflow tract in patients with normal left ventricular function.\n\t\t\t\t\tHeart2009;95(15):1230\u20137."},{"issue":"4","key":"i1526-6702-49-1-e207265-b21","series-title":"Pacing Clin Electrophysiol","first-page":"465","article-title":"Late gadolinium enhancement CMR in patients with tachycardia-induced cardiomyopathy caused by idiopathic ventricular arrhythmias","volume":"35","year":"2012","unstructured":"Hasdemir\n C,\n \n \n Yuksel\n A,\n \n \n Camli\n D,\n \n \n Kartal\n Y,\n \n \n Simsek\n E,\n \n \n Musayev\n O,\n \n \n .\n\t\t\t\t\tLate gadolinium enhancement CMR in patients with tachycardia-induced cardiomyopathy caused by idiopathic ventricular arrhythmias.\n\t\t\t\t\tPacing Clin Electrophysiol2012;35(4):465\u201370."}],"container-title":["Texas Heart Institute Journal"],"original-title":[],"link":[{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/49\/1\/article-e207265.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/thij\/article-pdf\/doi\/10.14503\/THIJ-20-7265\/3020593\/i1526-6702-49-1-e207265.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/49\/1\/article-e207265.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/49\/1\/article-e207265.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:37:01Z","timestamp":1730993821000},"score":1,"resource":{"primary":{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/49\/1\/article-e207265.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":21,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.14503\/thij-20-7265","relation":{},"ISSN":["1526-6702","0730-2347"],"issn-type":[{"type":"electronic","value":"1526-6702"},{"type":"print","value":"0730-2347"}],"subject":[],"published":{"date-parts":[[2022]]}}}