{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T05:24:23Z","timestamp":1731043463340,"version":"3.28.0"},"reference-count":24,"publisher":"Texas Heart Institute Journal","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"Mitral regurgitation can result from congenital heart disease, rheumatic valve disease, or other congenital malformations of the mitral valve. Faulty valves require surgical repair or replacement. However, echocardiographic and biochemical parameters that inform surgical decision-making for adults may not be appropriate for children. To investigate whether adult parameters can be used in children, we correlated echocardiographic parameters with serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in children with chronic mitral regurgitation.<\/jats:p>\n Our sample comprised 45 patients and 38 healthy children. M-mode measurements, left atrial and left ventricular volumes, and Doppler and tissue Doppler echocardiograms were collected. We graded mitral regurgitation according to European Association of Echocardiography recommendations and indexed effective regurgitant area, vena contracta, and regurgitant volume to body surface area. Patients were grouped by regurgitation severity (mild vs moderate or severe) and left ventricular end-systolic dimension (normal vs enlarged).<\/jats:p>\n The NT-proBNP level was higher in patients than in controls (P<\/jats:italic>=0.003), higher in patients with moderate or severe regurgitation (P<\/jats:italic>=0.02), and higher in patients with an enlarged left ventricle (P<\/jats:italic>=0.003). Serum NT-proBNP levels correlated with effective regurgitant area (r<\/jats:italic>=0.47; P<\/jats:italic>=0.002), vena contracta width (r<\/jats:italic>=0.46; P<\/jats:italic>=0.003), regurgitant volume (r<\/jats:italic>=0.32; P<\/jats:italic>=0.04), left ventricular end-systolic diameter (r<\/jats:italic>=0.58; P<\/jats:italic> <0.001), and left atrial diameter (r<\/jats:italic>=0.62; P<\/jats:italic> <0.001). An NT-proBNP value of 66 pg\/mL differentiated the mild regurgitation group from the moderate or severe regurgitation group.<\/jats:p>\n Our results correlating NT-proBNP and echocardiographic parameters indexed to body surface area indicate that these adult criteria can be used in children to grade mitral regurgitation and inform surgical decision-making.<\/jats:p>","DOI":"10.14503\/thij-20-7285","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T19:28:57Z","timestamp":1661801337000},"source":"Crossref","is-referenced-by-count":1,"title":["Mitral Regurgitation and Serum N-Terminal Pro-Brain Natriuretic Peptide Levels in Children: A Modification of Adult Criteria"],"prefix":"10.14503","volume":"49","author":[{"given":"Elif","family":"Erolu","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, University of Health Sciences Istanbul \u00dcmraniye Training and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"Akalin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Marmara University Faculty of Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"4","key":"i1526-6702-49-4-e207285-b1","series-title":"Eur J Echocardiogr","first-page":"307","article-title":"European Association of Echocardiography recommendations for the assessment of valvular regurgitation. Part 2: mitral and tricuspid regurgitation (native valve disease)","volume":"11","year":"2010","unstructured":"Lancellotti\n P,\n \n \n Moura\n L,\n \n \n Pierard\n LA,\n \n \n Agricola\n E,\n \n \n Popescu\n BA,\n \n \n Tribouilloy\n C,\n \n \n .\n\t\t\t\t\tEuropean Association of Echocardiography recommendations for the assessment of valvular regurgitation. Part 2: mitral and tricuspid regurgitation (native valve disease).\n\t\t\t\t\tEur J Echocardiogr2010;11(4):307\u201332."},{"issue":"23","key":"i1526-6702-49-4-e207285-b2","series-title":"Circulation","first-page":"2440","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/ American Heart Association Task Force on Practice Guidelines [published erratum appears in Circulation 2014;129(23):e650]","volume":"129","year":"2014","unstructured":"Nishimura\n RA,\n \n \n Otto\n CM,\n \n \n Bonow\n RO,\n \n \n Carabello\n BA,\n \n \n Erwin\n JP\n 3rd,\n \n \n Guyton\n RA,\n \n \n .\n\t\t\t\t\t2014 AHA\/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology\/ American Heart Association Task Force on Practice Guidelines [published erratum appears in Circulation 2014;129(23):e650].\n\t\t\t\t\tCirculation2014;129(23):2440\u201392."},{"issue":"3","key":"i1526-6702-49-4-e207285-b3","series-title":"Anadolu Kardiyol Derg","first-page":"167","article-title":"PISA method for assessment of mitral regurgitation in children","volume":"5","year":"2005","unstructured":"Baspinar\n O,\n \n \n Karaaslan\n S,\n \n \n Oran\n B.\n \n \n PISA method for assessment of mitral regurgitation in children.\n\t\t\t\t\tAnadolu Kardiyol Derg2005;5(3):167\u201371."},{"issue":"6","key":"i1526-6702-49-4-e207285-b4","series-title":"Pediatr Cardiol","first-page":"351","article-title":"Validation of the proximal isovelocity surface area method for assessing mitral regurgitation in children","volume":"17","year":"1996","unstructured":"Aotsuka\n H,\n \n \n Tobita\n K,\n \n \n Hamada\n H,\n \n \n Uchishiba\n M,\n \n \n Tateno\n S,\n \n \n Matsuo\n K,\n \n \n .\n\t\t\t\t\tValidation of the proximal isovelocity surface area method for assessing mitral regurgitation in children.\n\t\t\t\t\tPediatr Cardiol1996;17(6):351\u20139."},{"issue":"5","key":"i1526-6702-49-4-e207285-b5","series-title":"Cardiol Young","first-page":"495","article-title":"The value of serum N-terminal pro-brain natriuretic peptide levels in the differential diagnosis and follow-up of congestive cardiac failure and respiratory distress due to pulmonary aetiologies in infants and children","volume":"20","year":"2010","unstructured":"Evim\n MS,\n \n \n Ucar\n B,\n \n \n Kilic\n Z,\n \n \n Colak\n O.\n \n \n The value of serum N-terminal pro-brain natriuretic peptide levels in the differential diagnosis and follow-up of congestive cardiac failure and respiratory distress due to pulmonary aetiologies in infants and children.\n\t\t\t\t\tCardiol Young2010;20(5):495\u2013504."},{"issue":"21","key":"i1526-6702-49-4-e207285-b6","series-title":"J Am Coll Cardiol","first-page":"1961","article-title":"Survival implication of left ventricular end-systolic diameter in mitral regurgitation due to flail leaflets: a long-term follow-up multicenter study","volume":"54","year":"2009","unstructured":"Tribouilloy\n C,\n \n \n Grigioni\n F,\n \n \n Avierinos\n JF,\n \n \n Barbieri\n A,\n \n \n Rusinaru\n D,\n \n \n Szymanski\n C,\n \n \n .\n\t\t\t\t\tSurvival implication of left ventricular end-systolic diameter in mitral regurgitation due to flail leaflets: a long-term follow-up multicenter study.\n\t\t\t\t\tJ Am Coll Cardiol2009;54(21):1961\u20138."},{"issue":"4","key":"i1526-6702-49-4-e207285-b7","series-title":"J Med Liban","first-page":"197","article-title":"Epidemiology of mitral valve disease in pediatrics: a Lebanese study [in French]","volume":"59","year":"2011","unstructured":"Chehab\n G,\n \n \n El-Rassi\n I,\n \n \n Chokor\n I,\n \n \n Hammoud\n C,\n \n \n Saliba\n Z.\n \n \n Epidemiology of mitral valve disease in pediatrics: a Lebanese study [in French].\n\t\t\t\t\tJ Med Liban2011;59(4):197\u2013201."},{"issue":"10","key":"i1526-6702-49-4-e207285-b8","series-title":"Heart","first-page":"1243","article-title":"Preoperative left ventricular end systolic dimension as a predictor of postoperative ventricular dysfunction in children with mitral regurgitation","volume":"89","year":"2003","unstructured":"Lee\n JY,\n \n \n Noh\n CI,\n \n \n Bae\n EJ,\n \n \n Yun\n YS,\n \n \n Lee\n JR,\n \n \n Kim\n YJ.\n \n \n Preoperative left ventricular end systolic dimension as a predictor of postoperative ventricular dysfunction in children with mitral regurgitation.\n\t\t\t\t\tHeart2003;89(10):1243\u20134."},{"issue":"5","key":"i1526-6702-49-4-e207285-b9","series-title":"J Am Soc Echocardiogr","first-page":"465","article-title":"Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council","volume":"23","year":"2010","unstructured":"Lopez\n L,\n \n \n Colan\n SD,\n \n \n Frommelt\n PC,\n \n \n Ensing\n GJ,\n \n \n Kendall\n K,\n \n \n Younoszai\n AK,\n \n \n .\n\t\t\t\t\tRecommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council.\n\t\t\t\t\tJ Am Soc Echocardiogr2010;23(5):465\u201395."},{"issue":"3","key":"i1526-6702-49-4-e207285-b10","series-title":"J Am Coll Cardiol","first-page":"e1","article-title":"ACC\/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients with Valvular Heart Disease) developed in collaboration with the Society of Cardiovascular Anesthesiologists endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons [published erratum appears in J Am Coll Cardiol 2007;49(9):1014]","volume":"48","year":"2006","unstructured":"Bonow\n RO,\n \n \n Carabello\n BA,\n \n \n Chatterjee\n K,\n \n \n Leon\n AC\n Jr,\n \n \n Faxon\n DP,\n \n \n Freed\n MD,\n \n \n .\n\t\t\t\t\tACC\/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients with Valvular Heart Disease) developed in collaboration with the Society of Cardiovascular Anesthesiologists endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons [published erratum appears in J Am Coll Cardiol 2007;49(9):1014].\n\t\t\t\t\tJ Am Coll Cardiol2006;48(3):e1\u2013148."},{"issue":"5","key":"i1526-6702-49-4-e207285-b11","series-title":"Circ J","first-page":"998","article-title":"The role of N-terminal pro-B type natriuretic peptide in the diagnosis of congestive heart failure in children \u2013 correlation with the heart failure score and comparison with B-type natriuretic peptide","volume":"74","year":"2010","unstructured":"Sugimoto\n M,\n \n \n Manabe\n H,\n \n \n Nakau\n K,\n \n \n Furuya\n A,\n \n \n Okushima\n K,\n \n \n Fujiyasu\n H,\n \n \n .\n\t\t\t\t\tThe role of N-terminal pro-B type natriuretic peptide in the diagnosis of congestive heart failure in children \u2013 correlation with the heart failure score and comparison with B-type natriuretic peptide.\n\t\t\t\t\tCirc J2010;74(5):998\u20131005."},{"issue":"3","key":"i1526-6702-49-4-e207285-b12","series-title":"J Card Fail","first-page":"168","article-title":"Determining the optimal cutoff values of plasma N-terminal pro-B-type natriuretic peptide levels for the diagnosis of heart failure in children of age up to 14 years","volume":"20","year":"2014","unstructured":"Lin\n CW,\n \n \n Zeng\n XL,\n \n \n Zhang\n JF,\n \n \n Meng\n XH.\n \n \n Determining the optimal cutoff values of plasma N-terminal pro-B-type natriuretic peptide levels for the diagnosis of heart failure in children of age up to 14 years.\n\t\t\t\t\tJ Card Fail2014;20(3):168\u201373."},{"issue":"4","key":"i1526-6702-49-4-e207285-b13","series-title":"Acta Med Okayama","first-page":"191","article-title":"Plasma brain natriuretic peptide and the evaluation of volume overload in infants and children with congenital heart disease","volume":"57","year":"2003","unstructured":"Kunii\n Y,\n \n \n Kamada\n M,\n \n \n Ohtsuki\n S,\n \n \n Araki\n T,\n \n \n Kataoka\n K,\n \n \n Kageyama\n M,\n \n \n .\n\t\t\t\t\tPlasma brain natriuretic peptide and the evaluation of volume overload in infants and children with congenital heart disease.\n\t\t\t\t\tActa Med Okayama2003;57(4):191\u20137."},{"issue":"7","key":"i1526-6702-49-4-e207285-b14","series-title":"Eur Heart J","first-page":"861","article-title":"B-type natriuretic peptide in paediatric patients with congenital heart disease","volume":"27","year":"2006","unstructured":"Koch\n A,\n \n \n Zink\n S,\n \n \n Singer\n H.\n \n \n B-type natriuretic peptide in paediatric patients with congenital heart disease.\n\t\t\t\t\tEur Heart J2006;27(7):861\u20136."},{"issue":"1","key":"i1526-6702-49-4-e207285-b15","series-title":"Cardiol Young","first-page":"66","article-title":"Clinical and functional characterisation of rheumatic mitral regurgitation in children and adolescents including the brain natriuretic peptide","volume":"20","year":"2010","unstructured":"Ribeiro\n MCV,\n \n \n Filho\n BM,\n \n \n Santos\n CCL,\n \n \n Mello\n CPQ.\n \n \n Clinical and functional characterisation of rheumatic mitral regurgitation in children and adolescents including the brain natriuretic peptide.\n\t\t\t\t\tCardiol Young2010;20(1):66\u201372."},{"issue":"7","key":"i1526-6702-49-4-e207285-b16","series-title":"Clin Chem","first-page":"1438","article-title":"Reference values for plasma B-type natriuretic peptide in the first days of life","volume":"55","year":"2009","unstructured":"Cantinotti\n M,\n \n \n Storti\n S,\n \n \n Parri\n MS,\n \n \n Murzi\n M,\n \n \n Clerico\n A.\n \n \n Reference values for plasma B-type natriuretic peptide in the first days of life.\n\t\t\t\t\tClin Chem2009;55(7):1438\u201340."},{"issue":"1\u20132","key":"i1526-6702-49-4-e207285-b17","series-title":"Clin Chim Acta","first-page":"304","article-title":"Pediatric brain natriuretic peptide and N-terminal pro-brain natriuretic peptide reference intervals","volume":"366","year":"2006","unstructured":"Soldin\n SJ,\n \n \n Soldin\n OP,\n \n \n Boyajian\n AJ,\n \n \n Taskier\n MS.\n \n \n Pediatric brain natriuretic peptide and N-terminal pro-brain natriuretic peptide reference intervals.\n\t\t\t\t\tClin Chim Acta2006;366(1\u20132):304\u20138."},{"issue":"9","key":"i1526-6702-49-4-e207285-b18","series-title":"Clin Chem","first-page":"1563","article-title":"Plasma N-terminal pro-B-type natriuretic peptide concentrations in a control population of infants and children","volume":"49","year":"2003","unstructured":"Rauh\n M,\n \n \n Koch\n A.\n \n \n Plasma N-terminal pro-B-type natriuretic peptide concentrations in a control population of infants and children.\n\t\t\t\t\tClin Chem2003;49(9):1563\u20134."},{"issue":"4","key":"i1526-6702-49-4-e207285-b19","series-title":"Am J Cardiol","first-page":"559","article-title":"Relation of N-terminal pro-B-type natriuretic peptide to symptoms, severity, and left ventricular remodeling in patients with organic mitral regurgitation","volume":"104","year":"2009","unstructured":"Potocki\n M,\n \n \n Mair\n J,\n \n \n Weber\n M,\n \n \n Hamm\n C,\n \n \n Burkard\n T,\n \n \n Hiemetzberger\n R,\n \n \n .\n\t\t\t\t\tRelation of N-terminal pro-B-type natriuretic peptide to symptoms, severity, and left ventricular remodeling in patients with organic mitral regurgitation.\n\t\t\t\t\tAm J Cardiol2009;104(4):559\u201364."},{"issue":"2","key":"i1526-6702-49-4-e207285-b20","series-title":"Eur J Heart Fail","first-page":"163","article-title":"Prognostic value of serial B-type natriuretic peptide measurement in asymptomatic organic mitral regurgitation","volume":"13","year":"2011","unstructured":"Klaar\n U,\n \n \n Gabriel\n H,\n \n \n Bergler-Klein\n J,\n \n \n Pernicka\n E,\n \n \n Heger\n M,\n \n \n Mascherbauer\n J,\n \n \n .\n\t\t\t\t\tPrognostic value of serial B-type natriuretic peptide measurement in asymptomatic organic mitral regurgitation.\n\t\t\t\t\tEur J Heart Fail2011;13(2):163\u20139."},{"issue":"5","key":"i1526-6702-49-4-e207285-b21","series-title":"Ann Saudi Med","first-page":"469","article-title":"Correlation between plasma N-terminal pro-brain natriuretic peptide levels and changes in New York Heart Association functional class, left atrial size, left ventricular size and function after mitral and\/or aortic valve replacement","volume":"32","year":"2012","unstructured":"Elasfar\n A.\n \n \n Correlation between plasma N-terminal pro-brain natriuretic peptide levels and changes in New York Heart Association functional class, left atrial size, left ventricular size and function after mitral and\/or aortic valve replacement.\n\t\t\t\t\tAnn Saudi Med2012;32(5):469\u201372."},{"issue":"13 Suppl","key":"i1526-6702-49-4-e207285-b22","series-title":"J Am Coll Cardiol","first-page":"E800","article-title":"Can echocardiography assess mitral regurgitation severity in children? [abstract]","volume":"59","year":"2012","unstructured":"King\n WTY,\n \n \n Puchalski\n M,\n \n \n Minich\n LL,\n \n \n Tani\n L,\n \n \n Su\n J.\n \n \n Can echocardiography assess mitral regurgitation severity in children? [abstract].\n\t\t\t\t\tJ Am Coll Cardiol2012;59(13 Suppl):E800.\n\t\t\t\t\tAvailable at: https:\/\/doi.org\/10.1016\/S0735-1097(12)60801-8"},{"issue":"2","key":"i1526-6702-49-4-e207285-b23","series-title":"Pediatr Cardiol","first-page":"417","article-title":"Indications for intervention in asymptomatic children with chronic mitral regurgitation","volume":"36","year":"2015","unstructured":"Johnson\n JT,\n \n \n Eckhauser\n AW,\n \n \n Pinto\n NM,\n \n \n Weng\n HY,\n \n \n Minich\n LL,\n \n \n Tani\n LY.\n \n \n Indications for intervention in asymptomatic children with chronic mitral regurgitation.\n\t\t\t\t\tPediatr Cardiol2015;36(2):417\u201322."},{"issue":"12","key":"i1526-6702-49-4-e207285-b24","series-title":"Circulation","first-page":"4280","article-title":"Late left ventricular function after surgery for children with chronic symptomatic mitral regurgitation","volume":"96","year":"1997","unstructured":"Krishnan\n US,\n \n \n Gersony\n WM,\n \n \n Berman-Rosenzweig\n E,\n \n \n Apfel\n HD.\n \n \n Late left ventricular function after surgery for children with chronic symptomatic mitral regurgitation.\n\t\t\t\t\tCirculation1997;96(12):4280\u20135."}],"container-title":["Texas Heart Institute Journal"],"original-title":[],"link":[{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/49\/4\/article-e207285.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/thij\/article-pdf\/doi\/10.14503\/THIJ-20-7285\/3113417\/i1526-6702-49-4-e207285.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/49\/4\/article-e207285.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/49\/4\/article-e207285.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:37:58Z","timestamp":1730993878000},"score":1,"resource":{"primary":{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/49\/4\/article-e207285.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":24,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.14503\/thij-20-7285","relation":{},"ISSN":["1526-6702","0730-2347"],"issn-type":[{"type":"electronic","value":"1526-6702"},{"type":"print","value":"0730-2347"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}