{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T04:54:28Z","timestamp":1767675268899,"version":"3.28.0"},"reference-count":16,"publisher":"Texas Heart Institute Journal","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Carotid body tumors, rare neck paragangliomas arising from the common carotid artery bifurcation, can be classified as sporadic, hyperplastic, or familial. The familial type is often bilateral and associated with germline mutation of the mitochondrial enzyme succinate dehydrogenase. We report the rare case of a 42-year-old man who presented with bilateral giant familial carotid body tumors associated with a concomitant skull-base paraganglioma, left-sided facial nerve palsy, and an incomplete circle of Willis. We describe the excision of the tumors in 2 stages (the left mass and associated paraganglioma first and the right mass second), 6 months apart, with use of general anesthesia, and we discuss other operative considerations.<\/jats:p>","DOI":"10.14503\/thij-20-7370","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T15:29:48Z","timestamp":1650382188000},"source":"Crossref","is-referenced-by-count":2,"title":["Bilateral Giant Familial Carotid Body Tumors With Concomitant Skull-Base Paraganglioma and Facial Nerve Palsy"],"prefix":"10.14503","volume":"49","author":[{"given":"Nwadinma U.","family":"Emeruem","sequence":"first","affiliation":[{"name":"Division of Cardiothoracic Surgery, National Cardiothoracic Center of Excellence, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher C.","family":"Muoghalu","sequence":"additional","affiliation":[{"name":"Division of Anesthesiology, National Cardiothoracic Center of Excellence, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ndubueze","family":"Ezemba","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, National Cardiothoracic Center of Excellence, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"3","key":"i1526-6702-49-2-e207370-b1","series-title":"Oncol Lett","first-page":"3628","article-title":"Diagnosis and surgical treatment of carotid body tumor: a retrospective analysis of 58 patients","volume":"14","year":"2017","unstructured":"Hua\n              Q,\n            \n            \n              Xu\n              Z,\n            \n            \n              Jiang\n              Y.\n            \n          \n          Diagnosis and surgical treatment of carotid body tumor: a retrospective analysis of 58 patients.\n\t\t\t\t\tOncol Lett2017;14(3):3628\u201332."},{"issue":"4","key":"i1526-6702-49-2-e207370-b2","series-title":"Eur J Vasc Endovasc Surg","first-page":"477","article-title":"A systematic review and meta-analysis of the presentation and surgical management of patients with carotid body tumours","volume":"57","year":"2019","unstructured":"Robertson\n              V,\n            \n            \n              Poli\n              F,\n            \n            \n              Hobson\n              B,\n            \n            \n              Saratzis\n              A,\n            \n            \n              Ross Naylor\n              A.\n            \n          \n          A systematic review and meta-analysis of the presentation and surgical management of patients with carotid body tumours.\n\t\t\t\t\tEur J Vasc Endovasc Surg2019;57(4):477\u201386."},{"issue":"6","key":"i1526-6702-49-2-e207370-b3","series-title":"Adv Clin Exp Med","first-page":"1173","article-title":"Diagnostic and therapeutic difficulties in carotid body paragangliomas, based on clinical experience and a review of the literature","volume":"25","year":"2016","unstructured":"Dorobisz\n              K,\n            \n            \n              Dorobisz\n              T,\n            \n            \n              Temporale\n              H,\n            \n            \n              Zatonski\n              T,\n            \n            \n              Kubacka\n              M,\n            \n            \n              Chabowski\n              M,\n            \n          \n          .\n\t\t\t\t\tDiagnostic and therapeutic difficulties in carotid body paragangliomas, based on clinical experience and a review of the literature.\n\t\t\t\t\tAdv Clin Exp Med2016;25(6):1173\u20137."},{"issue":"4","key":"i1526-6702-49-2-e207370-b4","series-title":"Head Neck Pathol","first-page":"303","article-title":"Paraganglioma: carotid body 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Surg","first-page":"732","article-title":"Carotid body tumor (chemodectoma): clinicopathologic analysis of ninety cases","volume":"122","year":"1971","unstructured":"Shamblin\n              WR,\n            \n            \n              ReMine\n              WH,\n            \n            \n              Sheps\n              SG,\n            \n            \n              Harrison\n              EG\n              Jr.\n            \n          \n          Carotid body tumor (chemodectoma): clinicopathologic analysis of ninety cases.\n\t\t\t\t\tAm J Surg1971;122(6):732\u20139."},{"issue":"4","key":"i1526-6702-49-2-e207370-b7","series-title":"Oncol Lett","first-page":"5318","article-title":"Multi-institutional survey of carotid body tumors in Japan","volume":"15","year":"2018","unstructured":"Ikeda\n              A,\n            \n            \n              Shiga\n              K,\n            \n            \n              Katagiri\n              K,\n            \n            \n            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complications in carotid body tumors: a 6-year single-center experience.\n\t\t\t\t\tJ Vasc Surg2013;57(2 Suppl):64S\u20138S."},{"issue":"1","key":"i1526-6702-49-2-e207370-b9","series-title":"Egyptian Journal of Ear, Nose, Throat and Allied Sciences","first-page":"19","article-title":"Paraganglioma of the carotid body: report of 26 patients and review of the literature","volume":"16","year":"2015","unstructured":"Rim\n              Z,\n            \n            \n              Rim\n              B,\n            \n            \n              Houda\n              C,\n            \n            \n              Souheil\n              J,\n            \n            \n              Najeh\n              B,\n            \n            \n              Ghazi\n              B.\n            \n          \n          Paraganglioma of the carotid body: report of 26 patients and review of the literature.\n\t\t\t\t\tEgyptian Journal of Ear, Nose, Throat and Allied Sciences2015;16(1):19\u201323."},{"issue":"6","key":"i1526-6702-49-2-e207370-b10","series-title":"Oncol Lett","first-page":"6417","article-title":"Diagnosis and treatment of a carotid body tumor: a case report of a rare bilateral tumor","volume":"14","year":"2017","unstructured":"Sun\n              Q,\n            \n            \n              Xie\n              C,\n            \n            \n              Niu\n              Z,\n            \n            \n              Su\n              L,\n            \n            \n              Wang\n              X,\n            \n            \n              Fang\n              Z,\n            \n          \n          .\n\t\t\t\t\tDiagnosis and treatment of a carotid body tumor: a case report of a rare bilateral tumor.\n\t\t\t\t\tOncol Lett2017;14(6):6417\u201320."},{"issue":"6","key":"i1526-6702-49-2-e207370-b11","series-title":"J Vasc Surg","first-page":"1518","article-title":"Important observations made managing carotid body tumors during a 25-year experience","volume":"52","year":"2010","unstructured":"Kruger\n              AJ,\n            \n            \n              Walker\n              PJ,\n            \n            \n              Foster\n              WJ,\n            \n            \n              Jenkins\n              JS,\n            \n            \n              Boyne\n              NS,\n            \n            \n              Jenkins\n              J.\n            \n          \n          Important observations made managing carotid body tumors during a 25-year experience.\n\t\t\t\t\tJ Vasc Surg2010;52(6):1518\u201323."},{"key":"i1526-6702-49-2-e207370-b12","series-title":"Ann Vasc Surg","first-page":"54","article-title":"Carotid body tumor resection: just as safe without preoperative embolization","volume":"46","year":"2018","unstructured":"Cobb\n              AN,\n            \n            \n              Barkat\n              A,\n            \n            \n              Daungjaiboon\n              W,\n  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excision: a case report and brief review","volume":"8","year":"2014","unstructured":"Karigar\n              SL,\n            \n            \n              Kunakeri\n              S,\n            \n            \n              Shetti\n              AN.\n            \n          \n          Anesthetic management of carotid body tumor excision: a case report and brief review.\n\t\t\t\t\tAnesth Essays Res2014;8(2):259\u201362."},{"issue":"2","key":"i1526-6702-49-2-e207370-b16","series-title":"North Clin Istanb","first-page":"97","article-title":"Anesthetic approaches in carotid body tumor surgery","volume":"3","year":"2016","unstructured":"Kavakli\n              AS,\n            \n            \n              Ozturk\n              NK.\n            \n          \n          Anesthetic approaches in carotid body tumor surgery.\n\t\t\t\t\tNorth Clin Istanb2016;3(2):97\u2013103."}],"container-title":["Texas Heart Institute 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