{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T05:23:15Z","timestamp":1731043395502,"version":"3.28.0"},"reference-count":4,"publisher":"Texas Heart Institute Journal","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"Myocardial scintigraphy with technetium-99m pyrophosphate is a minimally invasive technique that can distinguish between transthyretin amyloidosis (ATTR) and light-chain amyloidosis. We present a case in which it helped determine the amyloidosis type in a 74-year-old man with cardiac amyloidosis and multiple previous admissions for acute decompensated heart failure.<\/jats:p>\n The patient presented with increasing abdominal girth and bilateral lower extremity edema. His medical history also included atrial fibrillation, liver cirrhosis, hypertension, stage 3 chronic kidney disease, and peripheral vascular disease. We prescribed guideline-directed medical therapy for his acute decompensated heart failure with cardiorenal syndrome and his decompensated cirrhosis.<\/jats:p>\n Two years previously, a presumptive diagnosis of ATTR cardiomyopathy had been made on the basis of the patient's age, predominantly cardiac involvement, an unremarkable serum protein electrophoresis result, and an abnormal free \u03ba\/\u03bb light-chain ratio of 2.24. Over the next year, the patient's clinical condition had worsened with the development of liver cirrhosis and peripheral neuropathy, and his free \u03ba\/\u03bb light-chain ratio had become even more abnormal. At the current presentation, a technetium-99m pyrophosphate nuclear scintigram revealed a free \u03ba\/\u03bb light-chain ratio of 1.52. This, combined with the patient's age and slow progression of primarily cardiac disease, supported the diagnosis of ATTR, and we prescribed tafamadis.<\/jats:p>\n This case suggests that technetium-99m pyrophosphate scintigraphy is valuable in definitively diagnosing ATTR cardiomyopathy and selecting patients who may benefit from disease-modifying therapy.<\/jats:p>","DOI":"10.14503\/thij-20-7379","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T14:23:19Z","timestamp":1661437399000},"source":"Crossref","is-referenced-by-count":1,"title":["Myocardial Scintigraphy in Diagnosing Cardiac Transthyretin Amyloidosis"],"prefix":"10.14503","volume":"49","author":[{"given":"Marija","family":"Petrovic","sequence":"first","affiliation":[{"name":"Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, New York"},{"name":"Department of Medicine, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Persio D.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, New York"},{"name":"Department of Cardiology, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calvin","family":"Eng","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, New York"},{"name":"Department of Cardiology, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahjabeen","family":"Rashid","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, New York"},{"name":"Department of Cardiology, James J. Peters Department of Veterans Affairs Medical Center, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"9","key":"i1526-6702-49-4-e207379-b1","series-title":"Circ Heart Fail","first-page":"e006075","article-title":"Expert consensus recommendations for the suspicion and diagnosis of transthyretin cardiac amyloidosis","volume":"12","year":"2019","unstructured":"Maurer\n MS,\n \n \n Bokhari\n S,\n \n \n Damy\n T,\n \n \n Dorbala\n S,\n \n \n Drachman\n BM,\n \n \n Fontana\n M,\n \n \n .\n\t\t\t\t\tExpert consensus recommendations for the suspicion and diagnosis of transthyretin cardiac amyloidosis.\n\t\t\t\t\tCirc Heart Fail2019;12(9):e006075."},{"issue":"1","key":"i1526-6702-49-4-e207379-b2","series-title":"Eur J Heart Fail","first-page":"39","article-title":"Emerging therapies in transthyretin amyloidosis - a new wave of hope after years of stagnancy?","volume":"22","year":"2020","unstructured":"M\u00fcller\n ML,\n \n \n Butler\n J,\n \n \n Heidecker\n B.\n \n \n Emerging therapies in transthyretin amyloidosis - a new wave of hope after years of stagnancy?\n \n Eur J Heart Fail\n \n 2020;22(1):39\u201353."},{"issue":"2","key":"i1526-6702-49-4-e207379-b3","series-title":"Circ Cardiovasc Imaging","first-page":"195","article-title":"(99m)Tc-pyrophosphate scintigraphy for differentiating light-chain cardiac amyloidosis from the transthyretin-related familial and senile cardiac amyloidoses","volume":"6","year":"2013","unstructured":"Bokhari\n S,\n \n \n Casta\u00f1o\n A,\n \n \n Pozniakoff\n T,\n \n \n Deslisle\n S,\n \n \n Latif\n F,\n \n \n Maurer\n MS.\n \n \n (99m)Tc-pyrophosphate scintigraphy for differentiating light-chain cardiac amyloidosis from the transthyretin-related familial and senile cardiac amyloidoses.\n\t\t\t\t\tCirc Cardiovasc Imaging2013;6(2):195\u2013201."},{"issue":"3","key":"i1526-6702-49-4-e207379-b4","series-title":"Circ Cardiovasc Imaging","first-page":"552","article-title":"How to image cardiac amyloidosis","volume":"7","year":"2014","unstructured":"Falk\n RH,\n \n \n Quarta\n CC,\n \n \n Dorbala\n S.\n \n \n How to image cardiac amyloidosis.\n\t\t\t\t\tCirc Cardiovasc Imaging2014;7(3):552\u201362."}],"container-title":["Texas Heart Institute Journal"],"original-title":[],"link":[{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/49\/4\/article-e207379.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/thij\/article-pdf\/doi\/10.14503\/THIJ-20-7379\/3113380\/i1526-6702-49-4-e207379.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/49\/4\/article-e207379.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/49\/4\/article-e207379.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:34:28Z","timestamp":1730993668000},"score":1,"resource":{"primary":{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/49\/4\/article-e207379.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":4,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.14503\/thij-20-7379","relation":{},"ISSN":["1526-6702","0730-2347"],"issn-type":[{"type":"electronic","value":"1526-6702"},{"type":"print","value":"0730-2347"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}