{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:15:14Z","timestamp":1789524914094,"version":"build-2803163510"},"reference-count":20,"publisher":"Texas Heart Institute Journal","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>von Willebrand factor (vWF) aids coagulation at sites of vessel injury. Elevated vWF levels have been associated with an increased risk of ischemic heart disease (IHD); however, it is unclear whether vWF deficiency, seen in patients with von Willebrand disease (vWD), protects people against IHD. We determined and compared the prevalence and risk of IHD in patients with versus without vWD by using data from the National Inpatient Sample (2009\u20132014), excluding patients younger than 18 and older than 75 years. The primary outcome was the odds ratio (OR) of IHD in patients with versus without vWD. Secondary outcomes were major medical comorbidities and demographic characteristics in patients with vWD.<\/jats:p>\n        <jats:p>Of 224,475,443 weighted hospital-discharge samples, we identified 82,809 patients with a vWD diagnosis. The odds of IHD were lower in patients with vWD than in those without (OR=0.54; 95% CI, 0.52\u20130.56). After multivariable logistic regression analysis and adjustment for age, sex, and typical IHD risk factors (hypertension, smoking, diabetes, hyperlipidemia, chronic kidney disease, obesity, and family history of IHD), the likelihood of IHD remained lower in patients with vWD than in patients without (OR=0.65; 95% CI, 0.63\u20130.67). Our study shows that vWF deficiency, as seen in patients with vWD, is associated with a decreased prevalence of IHD. Further investigation may confirm these findings.<\/jats:p>","DOI":"10.14503\/thij-20-7402","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T14:14:39Z","timestamp":1657635279000},"source":"Crossref","is-referenced-by-count":3,"title":["The Cardioprotective Potential of von Willebrand Disease in Ischemic Heart Disease"],"prefix":"10.14503","volume":"49","author":[{"given":"Nawfal","family":"Mihyawi","sequence":"first","affiliation":[{"name":"Internal Medicine Department, Creighton University, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ajmal","sequence":"additional","affiliation":[{"name":"Cardiology Department, University of Arizona, Tucson, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman R.","family":"Fath","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Creighton University, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikash","family":"Bhattarai","sequence":"additional","affiliation":[{"name":"Research Department, Valleywise Health, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beeletsega","family":"Yeneneh","sequence":"additional","affiliation":[{"name":"Cardiology Department, Creighton University, Phoenix, Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5628","reference":[{"issue":"9","key":"i1526-6702-49-4-e207402-b1","series-title":"Circulation","first-page":"e139","article-title":"Heart disease and stroke statistics-2020 update: a report from the American Heart Association","volume":"141","year":"2020","unstructured":"Virani\n              SS,\n            \n            \n              Alonso\n              A,\n            \n            \n              Benjamin\n              EJ,\n            \n            \n              Bittencourt\n              MS,\n         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Analysis of a national discharge register","volume":"13","year":"2015","unstructured":"Seaman\n              CD,\n            \n            \n              Yabes\n              J,\n            \n            \n              Comer\n              DM,\n            \n            \n              Ragni\n              MV.\n            \n          \n          Does deficiency of von Willebrand factor protect against cardiovascular disease? 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Invest","first-page":"722","article-title":"Resistance to arteriosclerosis in pigs with von Willebrand's disease: spontaneous and high cholesterol diet-induced arteriosclerosis","volume":"61","year":"1978","unstructured":"Fuster\n              W,\n            \n            \n              Bowie\n              EJ,\n            \n            \n              Lewis\n              JC,\n            \n            \n              Fass\n              DN,\n            \n            \n              Owen\n              CA\n              Jr,\n            \n            \n              Brown\n              AL.\n            \n          \n          Resistance to arteriosclerosis in pigs with von Willebrand's disease: spontaneous and high cholesterol diet-induced arteriosclerosis.\n\t\t\t\t\tJ Clin Invest1978;61(3):722\u201330."},{"issue":"5","key":"i1526-6702-49-4-e207402-b15","series-title":"Circ Res","first-page":"587","article-title":"Arteriosclerosis in normal and von Willebrand pigs: long-term 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Public Health (Oxf )","first-page":"138","article-title":"Systematic review of discharge coding accuracy","volume":"34","year":"2012","unstructured":"Burns\n              EM,\n            \n            \n              Rigby\n              E,\n            \n            \n              Mamidanna\n              R,\n            \n            \n              Bottle\n              A,\n            \n            \n              Aylin\n              P,\n            \n            \n              Ziprin\n              P,\n            \n            \n              Faiz\n              OD.\n            \n          \n          Systematic review of discharge coding accuracy.\n\t\t\t\t\tJ Public Health (Oxf )2012;34(1):138\u201348."},{"key":"i1526-6702-49-4-e207402-b20","series-title":"Circulation","first-page":"A13941","article-title":"The prevalence of cardiovascular disease in patients with von Willebrand disease: a potential therapeutic target [abstract]","volume":"142","year":"2020","unstructured":"Mihyawi\n              N,\n            \n            \n              Ajmal\n              M,\n            \n            \n              Hung\n              J,\n            \n            \n              Yeneneh\n              BT.\n            \n          \n          The prevalence of cardiovascular disease in patients with von Willebrand disease: a potential therapeutic target [abstract].\n\t\t\t\t\tCirculation2020;142:A13941.\n\t\t\t\t\tAvailable from: https:\/\/doi.org\/10.1161\/circ.142.suppl_3.13941"}],"container-title":["Texas Heart Institute 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