{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T12:44:10Z","timestamp":1766580250250,"version":"3.28.0"},"reference-count":16,"publisher":"Texas Heart Institute Journal","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Only 13 cases of renal cell carcinoma metastasis to the left atrium of the heart have been described. We report the case of a man in his 50s who had undergone radical nephrectomy for renal cell carcinoma in 2006 and presented with amnesia at our neurology department in 2020. Magnetic resonance images of the brain showed metastatic lesions; subsequent computed tomograms of the chest, abdomen, and pelvis revealed a mass in the left atrium and multiple metastases in the lung, pleura, and pancreas. Our cardiologists advised against surgical removal of the left atrial mass because of a poor prognosis, so radiation therapy and immunotherapy were initiated instead.<\/jats:p>","DOI":"10.14503\/thij-20-7452","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T14:35:07Z","timestamp":1654698907000},"source":"Crossref","is-referenced-by-count":3,"title":["Renal Cell Carcinoma Metastasis to the Left Atrium"],"prefix":"10.14503","volume":"49","author":[{"given":"Aizaz","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shifa International Hospital, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeedullah","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shifa International Hospital, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Furrukh","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Shifa International Hospital, Islamabad, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"8","key":"i1526-6702-49-3-e207452-b1","series-title":"Can J Cardiol","first-page":"675","article-title":"A 30-year analysis of cardiac neoplasms at autopsy","volume":"21","year":"2005","unstructured":"Butany\n              J,\n            \n            \n              Leong\n              SW,\n            \n            \n              Carmichael\n              K,\n            \n            \n              Komeda\n              M.\n            \n          \n          A 30-year analysis of cardiac neoplasms at autopsy.\n\t\t\t\t\tCan J Cardiol2005;21(8):675\u201380."},{"issue":"10","key":"i1526-6702-49-3-e207452-b2","series-title":"Arch Pathol Lab Med","first-page":"1027","article-title":"Tumors of the heart: a 20-year experience with a review of 12,485 consecutive autopsies","volume":"117","year":"1993","unstructured":"Lam\n              KY,\n            \n            \n              Dickens\n              P,\n            \n            \n              Chan\n              AC.\n            \n          \n          Tumors of the heart: a 20-year experience with a review of 12,485 consecutive autopsies.\n\t\t\t\t\tArch Pathol Lab Med1993;117(10):1027\u201331."},{"key":"i1526-6702-49-3-e207452-b3","series-title":"Front Oncol","first-page":"738","article-title":"Renal cell carcinoma metastasizing to left atrium with coronary sinus invasion: a rare site of metastasis mimicking myxoma","volume":"9","year":"2019","unstructured":"Nkengurutse\n              G,\n            \n            \n              Wang\n              Q,\n            \n            \n              Tian\n              F,\n            \n            \n              Jiang\n              S,\n            \n            \n              Zhang\n              L,\n            \n            \n              Sun\n              W.\n            \n          \n          Renal cell carcinoma metastasizing to left atrium with coronary sinus invasion: a rare site of metastasis mimicking myxoma.\n\t\t\t\t\tFront Oncol2019;9:738."},{"issue":"14","key":"i1526-6702-49-3-e207452-b4","series-title":"Can J Cardiol","first-page":"1231","article-title":"Cardiac metastasis from a renal cell carcinoma","volume":"22","year":"2006","unstructured":"Alghamdi\n              A,\n            \n            \n              Tam\n              J.\n            \n          \n          Cardiac metastasis from a renal cell carcinoma.\n\t\t\t\t\tCan J Cardiol2006;22(14):1231\u20132."},{"issue":"2","key":"i1526-6702-49-3-e207452-b5","series-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub","first-page":"183","article-title":"Renal cell carcinoma: review of etiology, pathophysiology and risk factors","volume":"160","year":"2016","unstructured":"Petejova\n              N,\n            \n            \n              Martinek\n              A.\n            \n          \n          Renal cell carcinoma: review of etiology, pathophysiology and risk factors.\n\t\t\t\t\tBiomed Pap Med Fac Univ Palacky Olomouc Czech Repub2016;160(2):183\u201394."},{"issue":"1","key":"i1526-6702-49-3-e207452-b6","series-title":"Tex Heart Inst J","first-page":"48","article-title":"Renal cell carcinoma, metastatic to the left ventricle","volume":"36","year":"2009","unstructured":"Aburto\n              J,\n            \n            \n              Bruckner\n              BA,\n            \n            \n              Blackmon\n              SH,\n            \n            \n              Beyer\n              EA,\n            \n            \n              Reardon\n              MJ.\n            \n          \n          Renal cell carcinoma, metastatic to the left ventricle.\n\t\t\t\t\tTex Heart Inst J2009;36(1):48\u20139."},{"issue":"7","key":"i1526-6702-49-3-e207452-b7","series-title":"J Am Coll Cardiol","first-page":"1664","article-title":"Obstruction of right ventricular outflow tract caused by intracavitary metastatic disease: analysis of 14 cases","volume":"19","year":"1992","unstructured":"Labib\n              SB,\n            \n            \n              Schick\n              EC\n              Jr,\n            \n            \n              Isner\n              JM.\n            \n          \n          Obstruction of right ventricular outflow tract caused by intracavitary metastatic disease: analysis of 14 cases.\n\t\t\t\t\tJ Am Coll Cardiol1992;19(7):1664\u20138."},{"issue":"2","key":"i1526-6702-49-3-e207452-b8","series-title":"Clin Genitourin Cancer","first-page":"e327","article-title":"The clinical presentation, survival outcomes, and management of patients with renal cell carcinoma and cardiac metastasis without inferior vena cava involvement: results from a pooled clinical trial database and systematic review of reported cases","volume":"16","year":"2018","unstructured":"Viteri Malone\n              MA,\n            \n            \n              Ares\n              GR,\n            \n            \n              De Velasco\n              G,\n            \n            \n              Brand\u00e3o\n              R,\n            \n            \n              Lin\n              X,\n            \n            \n              Norton\n              C,\n            \n          \n          .\n\t\t\t\t\tThe clinical presentation, survival outcomes, and management of patients with renal cell carcinoma and cardiac metastasis without inferior vena cava involvement: results from a pooled clinical trial database and systematic review of reported cases.\n\t\t\t\t\tClin Genitourin Cancer2018;16(2):e327\u201333."},{"key":"i1526-6702-49-3-e207452-b9","series-title":"BMC Urol","first-page":"73","article-title":"Renal cell carcinoma with intramyocardial metastases","volume":"14","year":"2014","unstructured":"Czarnecka\n              AM,\n            \n            \n              Sobczuk\n              P,\n            \n            \n              Lian\n              F,\n            \n            \n              Szczylik\n              C.\n            \n          \n          Renal cell carcinoma with intramyocardial metastases.\n\t\t\t\t\tBMC Urol2014;14:73."},{"issue":"4","key":"i1526-6702-49-3-e207452-b10","series-title":"Can Med Assoc J","first-page":"368","article-title":"Tumours of the heart: histopathological and clinical study","volume":"30","year":"1934","unstructured":"Lymburner\n              RM.\n            \n          \n          Tumours of the heart: histopathological and clinical study.\n\t\t\t\t\tCan Med Assoc J1934;30(4):368\u201373."},{"issue":"3","key":"i1526-6702-49-3-e207452-b11","series-title":"Int J Clin Oncol","first-page":"271","article-title":"Cardiac metastasis from renal cell carcinoma without inferior vena involvement: a review of the literature based on a case report. Two different patterns of spread?","volume":"13","year":"2008","unstructured":"Zustovich\n              F,\n            \n            \n              Gottardo\n              F,\n            \n            \n              De Zorzi\n              L,\n            \n            \n              Cecchetto\n              A,\n            \n            \n              Dal Bianco\n              M,\n            \n            \n              Mauro\n              E,\n            \n            \n              Cartei\n              G.\n            \n          \n          Cardiac metastasis from renal cell carcinoma without inferior vena involvement: a review of the literature based on a case report. Two different patterns of spread?\n          \n            Int J Clin Oncol\n          \n          2008;13(3):271\u20134."},{"key":"i1526-6702-49-3-e207452-b12","series-title":"BMC Res Notes","first-page":"520","article-title":"Left atrial metastasis of renal cell carcinoma: a case report and review of the literature","volume":"7","year":"2014","unstructured":"Ohba\n              K,\n            \n            \n              Miyata\n              Y,\n            \n            \n              Mitsunari\n              K,\n            \n            \n              Matsuo\n              T,\n            \n            \n              Mochizuki\n              Y,\n            \n            \n              Sakai\n              H.\n            \n          \n          Left atrial metastasis of renal cell carcinoma: a case report and review of the literature.\n\t\t\t\t\tBMC Res Notes2014;7:520."},{"issue":"6","key":"i1526-6702-49-3-e207452-b13","series-title":"Eur Urol Oncol","first-page":"708","article-title":"First-line treatment of metastatic renal cell carcinoma: a systematic review and network meta-analysis","volume":"2","year":"2019","unstructured":"Hahn\n              AW,\n            \n            \n              Klaassen\n              Z,\n            \n            \n              Agarwal\n              N,\n            \n            \n              Haaland\n              B,\n            \n            \n              Esther\n              J,\n            \n            \n              Ye\n              XY,\n            \n          \n          .\n\t\t\t\t\tFirst-line treatment of metastatic renal cell carcinoma: a systematic review and network meta-analysis.\n\t\t\t\t\tEur Urol Oncol2019;2(6):708\u201315."},{"issue":"11","key":"i1526-6702-49-3-e207452-b14","series-title":"AJHO","first-page":"23","article-title":"Metastatic renal cell carcinoma invading the pulmonary vein and left atrium: an extremely rare occurrence treated with temsirolimus","volume":"12","year":"2016","unstructured":"Tolay\n              S,\n            \n            \n              Gupta\n              R,\n            \n            \n              Jumonville\n              AJ.\n            \n          \n          Metastatic renal cell carcinoma invading the pulmonary vein and left atrium: an extremely rare occurrence treated with temsirolimus.\n\t\t\t\t\tAJHO2016;12(11):23\u20136."},{"issue":"3","key":"i1526-6702-49-3-e207452-b15","series-title":"Case Rep Oncol","first-page":"861","article-title":"Rare case of intracardiac renal cell carcinoma metastasis with response to nivolumab: case report and literature review","volume":"11","year":"2018","unstructured":"Ansari\n              J,\n            \n            \n              Alhelali\n              S,\n            \n            \n              Albinmousa\n              Z,\n            \n            \n              Farrag\n              A,\n            \n            \n              Ali\n              AM,\n            \n            \n              Abdelgelil\n              M,\n            \n          \n          .\n\t\t\t\t\tRare case of intracardiac renal cell carcinoma metastasis with response to nivolumab: case report and literature review.\n\t\t\t\t\tCase Rep Oncol2018;11(3):861\u201370."},{"issue":"2","key":"i1526-6702-49-3-e207452-b16","series-title":"Hinyokika Kiyo","first-page":"97","article-title":"A case of myocardiac metastasis of clear cell renal carcinoma successfully treated with sunitinib [in Japanese]","volume":"59","year":"2013","unstructured":"Tatenuma\n              T,\n            \n            \n              Yao\n              M,\n            \n            \n              Sakata\n              R,\n            \n            \n              Sano\n              F,\n            \n            \n              Makiyama\n              K,\n            \n            \n              Nakaigawa\n              N,\n            \n          \n          .\n\t\t\t\t\tA case of myocardiac metastasis of clear cell renal carcinoma successfully treated with sunitinib [in Japanese].\n\t\t\t\t\tHinyokika Kiyo2013;59(2):97\u2013101."}],"container-title":["Texas Heart Institute Journal"],"original-title":[],"link":[{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/49\/3\/article-e207452.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/thij\/article-pdf\/doi\/10.14503\/THIJ-20-7452\/3069622\/i1526-6702-49-3-e207452.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/49\/3\/article-e207452.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/49\/3\/article-e207452.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:37:31Z","timestamp":1730993851000},"score":1,"resource":{"primary":{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/49\/3\/article-e207452.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":16,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.14503\/thij-20-7452","relation":{},"ISSN":["1526-6702","0730-2347"],"issn-type":[{"type":"electronic","value":"1526-6702"},{"type":"print","value":"0730-2347"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}