{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:30:52Z","timestamp":1762432252378,"version":"3.28.0"},"reference-count":28,"publisher":"Texas Heart Institute Journal","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Durable left ventricular assist devices (LVADs) provide circulatory support in patients with end-stage heart failure; however, complications include infection of the driveline exit site. Nontuberculous mycobacterial infections are rare in patients with LVADs, but they should be considered in those who have undergone device exchanges and have bacterial infections with driveline exit-site discharge but no fever or leukocytosis.<\/jats:p>\n        <jats:p>We reviewed the charts of patients who had an LVAD implanted at our institution from January 2009 through December 2019, to identify those with a device-related nontuberculous mycobacterial infection. Collected data included patient demographics, premorbid conditions, infection type, previous device complications, treatment, and outcomes. We identified infections in 3 patients (mean age, 41 yr): <jats:italic>Mycobacterium abscessus<\/jats:italic> in 2 and <jats:italic>M. chimaera<\/jats:italic> in 1. All had a HeartMate II device and had undergone device exchanges for pump thrombosis or for driveline fault or infections. All presented with driveline exit-site discharge without fever or leukocytosis. The mean time between initial device implantation and diagnosis of a nontuberculous mycobacterial infection was 55 months. All 3 patients were treated with antibiotics and underwent localized surgical d\u00e9bridement; one underwent an additional device exchange. The <jats:italic>M. abscessus<\/jats:italic> infections disseminated, and both patients died; the patient with <jats:italic>M. chimaera<\/jats:italic> infection continued to take suppressive antibiotics.<\/jats:p>\n        <jats:p>Nontuberculous mycobacterial infections are associated with high morbidity and mortality rates, warranting prompt diagnosis and treatment.<\/jats:p>","DOI":"10.14503\/thij-20-7498","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T14:05:51Z","timestamp":1657893951000},"source":"Crossref","is-referenced-by-count":5,"title":["Nontuberculous Mycobacterial Infections Associated With Left Ventricular Assist Devices in 3 Patients"],"prefix":"10.14503","volume":"49","author":[{"given":"Manavotam","family":"Singh","sequence":"first","affiliation":[{"name":"Division of Cardiology, MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrinalini","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elena","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, MedStar Washington Hospital Center, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farooq H.","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"23","key":"i1526-6702-49-4-e207498-b1","series-title":"N Engl J Med","first-page":"2241","article-title":"Advanced heart failure treated with 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receiving left ventricular assist devices as destination therapy.\n\t\t\t\t\tMayo Clin Proc2011;86(6):493\u2013500."},{"issue":"4","key":"i1526-6702-49-4-e207498-b7","series-title":"J Heart Lung Transplant","first-page":"375","article-title":"Working formulation for the standardization of definitions of infections in patients using ventricular assist devices","volume":"30","year":"2011","unstructured":"Hannan\n              MM,\n            \n            \n              Husain\n              S,\n            \n            \n              Mattner\n              F,\n            \n            \n              Danziger-Isakov\n              L,\n            \n            \n              Drew\n              RJ,\n            \n            \n              Corey\n              GR,\n            \n          \n          .\n\t\t\t\t\tWorking formulation for the standardization of definitions of infections in patients using ventricular assist devices.\n\t\t\t\t\tJ Heart Lung 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pathogen?","volume":"20","year":"2018","unstructured":"Nunez Breton\n              JD,\n            \n            \n              Hernandez\n              G,\n            \n            \n              Simkins\n              J,\n            \n            \n              Chaparro\n              SV.\n            \n          \n          Mycobacterium abscessus left ventricle assist device driveline infections: an emerging pathogen?\n          \n            Transpl Infect Dis\n          \n          2018;20(5):e12957."},{"key":"i1526-6702-49-4-e207498-b10","series-title":"Int J Infect Dis","first-page":"127","article-title":"Mycobacterium chelonae, an \u2018atypical' cause of an LVAD driveline infection","volume":"92","year":"2020","unstructured":"Roest\n              S,\n            \n            \n              Bax\n              HI,\n            \n            \n              Verkaik\n              NJ,\n            \n            \n              Brugts\n              JJ,\n            \n     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infections: a multicentric study","volume":"23","year":"2017","unstructured":"Sim\u00e9on\n              S,\n            \n            \n              Fl\u00e9cher\n              E,\n            \n            \n              Revest\n              M,\n            \n            \n              Niculescu\n              M,\n            \n            \n              Roussel\n              JC,\n            \n            \n              Michel\n              M,\n            \n          \n          .\n\t\t\t\t\tLeft ventricular assist device-related infections: a multicentric study.\n\t\t\t\t\tClin Microbiol Infect2017;23(10):748\u201351."},{"issue":"10","key":"i1526-6702-49-4-e207498-b16","series-title":"J Heart Lung Transplant","first-page":"1137","article-title":"An ISHLT consensus document for prevention and management strategies for mechanical circulatory support infection","volume":"36","year":"2017","unstructured":"Kusne\n              S,\n            \n            \n              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