{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T05:23:23Z","timestamp":1731043403455,"version":"3.28.0"},"reference-count":24,"publisher":"Texas Heart Institute Journal","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:sec>\n          <jats:title>Background<\/jats:title>\n          <jats:p>Aortic valve replacement improves survival for patients with low-gradient aortic valve stenosis, but there is a paucity of data on postoperative quality of life for this population.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Methods<\/jats:title>\n          <jats:p>In a single-center retrospective analysis of 304 patients with severe aortic valve stenosis who underwent transcatheter aortic valve replacement, patients were divided into 4 groups based on mean pressure gradient, left ventricular ejection fraction, and stroke volume index. Using the Kansas City Cardiomyopathy Questionnaire-12, quality of life was assessed immediately before and 1 month after transcatheter aortic valve replacement.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Results<\/jats:title>\n          <jats:p>Most patients in the low-flow, low-gradient group were men; this group had higher relative rates of cardiovascular disease and type 2 diabetes than the paradoxical low-flow, low-gradient group; the normal-flow, low-gradient group; and the high-gradient group. All-cause mortality did not differ significantly among the groups at 1 month after surgery, and all groups experienced a significant improvement in quality-of-life scores after surgery. The mean improvement was 27 points in the low-flow, low-gradient group, 25 points in the paradoxical low-flow, low-gradient group, 30 points in the normal-flow, low-gradient group, and 30 points in the high-gradient group (all <jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Conclusion<\/jats:title>\n          <jats:p>Quality of life improves significantly across all subgroups of aortic valve stenosis after trans-catheter aortic valve replacement, regardless of flow characteristics or aortic valve gradients.<\/jats:p>\n        <\/jats:sec>","DOI":"10.14503\/thij-21-7659","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T14:27:23Z","timestamp":1674656843000},"source":"Crossref","is-referenced-by-count":1,"title":["Transcatheter Aortic Valve Replacement for Severe Aortic Valve Stenosis: Do Patients Experience Better Quality of Life Regardless of Gradient?"],"prefix":"10.14503","volume":"50","author":[{"given":"Anthony","family":"Simone","sequence":"first","affiliation":[{"name":"Department of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California"},{"name":"Department of Cardiology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juka S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Huchting","sequence":"additional","affiliation":[{"name":"Department of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asim","family":"Rafique","sequence":"additional","affiliation":[{"name":"Department of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruhsen","family":"Ozcaglayan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Shemin","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olcay","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, David Geffen School of 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