{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T05:23:14Z","timestamp":1731043394675,"version":"3.28.0"},"reference-count":8,"publisher":"Texas Heart Institute Journal","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>A 73-year-old male patient presented with shortness of breath at rest resulting from new-onset severe primary mitral regurgitation with a flail posterior leaflet, left ventricular dysfunction, and cardiogenic shock. After initial stabilization in the intensive care unit, multiple treatment options were considered for this patient, all associated with significant mortality. Ultimately, operative mitral valve repair with Impella 5.5 placement was performed for postoperative hemodynamic support. Surgical repair provided elimination of mitral regurgitation. Impella support was maintained for 7 days to provide unloading of the left ventricle. After device removal, the patient had sustained left ventricular recovery with significantly improved ejection fraction. Full left ventricular support and unloading may decrease operative risk and promote left ventricular recovery in patients with severe mitral regurgitation and left ventricular dysfunction. This case emphasizes the value of ventricular unloading to facilitate the recovery of left ventricular function as a treatment option for patients with challenging cases of severe mitral regurgitation and left ventricular dysfunction.<\/jats:p>","DOI":"10.14503\/thij-22-7912","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T15:33:23Z","timestamp":1679499203000},"source":"Crossref","is-referenced-by-count":0,"title":["Enhanced Left Ventricular Recovery in Treatment of Mitral Regurgitation With Severe Left Ventricular Dysfunction"],"prefix":"10.14503","volume":"50","author":[{"given":"Robert","family":"Devich","sequence":"first","affiliation":[{"name":"Penn State University College of Medicine, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balakrishnan","family":"Mahesh","sequence":"additional","affiliation":[{"name":"Penn State Heart and Vascular Institute, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geetha","family":"Bhat","sequence":"additional","affiliation":[{"name":"Penn State Heart and Vascular Institute, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Kozak","sequence":"additional","affiliation":[{"name":"Penn State Heart and Vascular Institute, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Choi","sequence":"additional","affiliation":[{"name":"Penn State University College of Medicine, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel","family":"Melton","sequence":"additional","affiliation":[{"name":"Penn State Heart and Vascular Institute, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Dowling","sequence":"additional","affiliation":[{"name":"Penn State Heart and Vascular Institute, Penn State Health Milton S. 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cardiogenic shock: a 20-year outcome analysis in a non-transplant unit","volume":"11","year":"2016","unstructured":"Khorsandi\n              M,\n            \n            \n              Shaikhrezai\n              K,\n            \n            \n              Prasad\n              S,\n            \n          \n          .\n\t\t\t\t\tAdvanced mechanical circulatory support for post-cardiotomy cardiogenic shock: a 20-year outcome analysis in a non-transplant unit.\n\t\t\t\t\tJ Cardiothorac Surg.2016;11:29.\n\t\t\t\t\tdoi:10.1186\/s13019-016-0430-2"},{"issue":"3","key":"i1526-6702-50-2-e227912-b4","series-title":"Ann Thorac Surg.","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.athoracsur.2020.12.038","article-title":"The Society of Thoracic Surgeons Intermacs 2020 Annual Report","volume":"111","year":"2021","unstructured":"Molina\n              EJ,\n            \n            \n              Shah\n              P,\n            \n            \n              Kiernan\n              MS,\n            \n          \n          .\n\t\t\t\t\tThe Society of Thoracic Surgeons Intermacs 2020 Annual Report.\n\t\t\t\t\tAnn Thorac Surg.2021;111(3):778\u2013792.\n\t\t\t\t\tdoi:10.1016\/j.athoracsur.2020.12.038"},{"issue":"1","key":"i1526-6702-50-2-e227912-b5","series-title":"JACC Cardiovasc Interv.","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jcin.2020.08.037","article-title":"Transcatheter mitral valve repair in cardiogenic shock and mitral regurgitation: a patient-level, multicenter analysis","volume":"14","year":"2021","unstructured":"Jung\n              RG,\n            \n            \n              Simard\n              T,\n            \n            \n              Kovach\n              C,\n            \n          \n          .\n\t\t\t\t\tTranscatheter mitral valve repair in cardiogenic shock and mitral regurgitation: a patient-level, multicenter analysis.\n\t\t\t\t\tJACC Cardiovasc Interv.2021;14(1):1\u201311.\n\t\t\t\t\tdoi:10.1016\/j.jcin.2020.08.037"},{"issue":"8","key":"i1526-6702-50-2-e227912-b6","series-title":"Eur J Heart Fail.","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1002\/ejhf.2211","article-title":"Primary results of long-term outcomes in the MOMENTUM 3 pivotal trial and continued access protocol study phase: a study of 2200 HeartMate 3 left ventricular assist device implants","volume":"23","year":"2021","unstructured":"Mehra\n              MR,\n            \n            \n              Cleveland\n              JC\n              Jr,\n            \n            \n              Uriel\n              N,\n            \n          \n          .\n\t\t\t\t\tPrimary results of long-term outcomes in the MOMENTUM 3 pivotal trial and continued access protocol study phase: a study of 2200 HeartMate 3 left ventricular assist device implants.\n\t\t\t\t\tEur J Heart 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analysis.\n\t\t\t\t\tAnesthesiology.2014;120(5):1098\u20131108.\n\t\t\t\t\tdoi:10.1097\/ALN.0000000000000224"},{"issue":"5","key":"i1526-6702-50-2-e227912-b8","series-title":"Ann Thorac Surg.","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1016\/j.athoracsur.2019.08.041","article-title":"A new paradigm in mechanical circulatory support: 100-patient experience","volume":"109","year":"2020","unstructured":"Chung\n              JS,\n            \n            \n              Emerson\n              D,\n            \n            Ramzy,\n            .\n\t\t\t\t\t\n          A new paradigm in mechanical circulatory support: 100-patient experience.\n\t\t\t\t\tAnn Thorac Surg.2020;109(5):1370\u20131377.\n\t\t\t\t\tdoi:10.1016\/j.athoracsur.2019.08.041"}],"container-title":["Texas Heart Institute 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