{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:14:55Z","timestamp":1768338895878,"version":"3.49.0"},"reference-count":15,"publisher":"Texas Heart Institute Journal","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:sec>\n          <jats:title>Background<\/jats:title>\n          <jats:p>Arrhythmogenic right ventricular (RV) cardiomyopathy is a progressive disease characterized by the replacement of the normal myocardium with fibrofatty tissue. This study aimed to determine the value of echocardiographic RV deformation parameters in predicting electrical progression as assessed by serial changes in RV lead sensing and threshold in patients with arrhythmogenic RV cardiomyopathy.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Methods<\/jats:title>\n          <jats:p>The present study recruited 40 patients with a definitive diagnosis of arrhythmogenic RV cardiomyopathy at a mean (SD) age of 38.6 (14.2) years between 2018 and 2020. All patients had received an implantable cardioverter-defibrillator for the primary or secondary prevention of sudden cardiac death. The patients underwent 2-dimensional (2D) and 3-dimensional (3D) transthoracic echocardiographic examinations and RV 2D and 3D strain analyses, comprising free-wall longitudinal strain, global longitudinal strain, and strain rate. They were then followed up for electrical progression.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Results<\/jats:title>\n          <jats:p>During a mean (SD) follow-up period of 20 (6) months, the RV lead amplitude decreased from 7.95 (IQR, 4.53-10.25) mV to 5.25 (IQR, 2.88-8.55) mV (<jats:italic>P<\/jats:italic> &lt; .001), and the lead threshold increased from 0.75 (IQR, 0.50-0.79) V to 0.75 (IQR, 0.75-1.00) V (<jats:italic>P<\/jats:italic> &lt; .001). Right ventricular 2D free-wall (\u03c1 = 0.56, <jats:italic>P<\/jats:italic> = .01), RV 2D global (\u03c1 = 0.58, <jats:italic>P<\/jats:italic> = .007), and RV 3D free-wall (\u03c1 = 0.65; <jats:italic>P<\/jats:italic> = .003) longitudinal strain correlated with electrical progression.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Conclusion<\/jats:title>\n          <jats:p>Right ventricular 2D and 3D deformation parameters were found to be significant predictors of electrical progression during follow-up of patients with arrhythmogenic RV cardiomyopathy. These findings suggest that echocardiography has a pivotal role in predicting patients at high risk for electrical progression.<\/jats:p>\n        <\/jats:sec>","DOI":"10.14503\/thij-22-7944","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T19:24:50Z","timestamp":1690399490000},"source":"Crossref","is-referenced-by-count":1,"title":["The Value of Strain Echocardiography in Predicting Electrical Progression in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy"],"prefix":"10.14503","volume":"50","author":[{"given":"Leila","family":"Hosseini","sequence":"first","affiliation":[{"name":"Department of Echocardiography, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Cardiology, North Khorasan University of Medical Sciences, Bojnurd, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahid","family":"Rezaeian","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Sadeghpour","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Amirajam","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Farzamnia","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanaz","family":"Asadian","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hooman","family":"Bakhshandeh","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Cardiology, University Heart Center Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Emkanjoo","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"9671","key":"i1526-6702-50-4-e227944-b1","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/S0140-6736(09)60256-7","article-title":"Arrhythmogenic right ventricular cardiomyopathy","volume":"373","author":"Basso\n              C","year":"2009","unstructured":"Basso\n              C\n            , CorradoD, MarcusFI, NavaA, ThieneG. Arrhythmogenic right ventricular cardiomyopathy. Lancet. 2009;373(9671):1289\u2013300. doi:10.1016\/S0140-6736(09)60256-7"},{"issue":"11","key":"i1526-6702-50-4-e227944-b2","series-title":"J Cardiovasc Electrophysiol","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1111\/j.1540-8167.2008.01228.x","article-title":"Diagnostic value of endomyocardial biopsy guided by electroanatomic voltage mapping in arrhythmogenic right ventricular cardiomyopathy\/dysplasia","volume":"19","author":"Avella\n              A","year":"2008","unstructured":"Avella\n              A\n            , d\u2019AmatiG, PappalardoA, et al.\n          Diagnostic value of endomyocardial biopsy guided by electroanatomic voltage mapping in arrhythmogenic right ventricular cardiomyopathy\/dysplasia. J Cardiovasc Electrophysiol. 2008;19(11):1127\u20131134. doi:10.1111\/j.1540-8167.2008.01228.x"},{"issue":"3","key":"i1526-6702-50-4-e227944-b3","series-title":"Br Heart J","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1136\/hrt.71.3.215","article-title":"Diagnosis of arrhythmogenic right ventricular dysplasia\/cardiomyopathy. Task Force of the Working Group Myocardial and Pericardial Disease of the European Society of Cardiology and of the Scientific Council on Cardiomyopathies of the International Society","volume":"71","author":"McKenna\n              WJ","year":"1994","unstructured":"McKenna\n              WJ\n            , ThieneG, NavaA, et al.\n          Diagnosis of arrhythmogenic right ventricular dysplasia\/cardiomyopathy. Task Force of the Working Group Myocardial and Pericardial Disease of the European Society of Cardiology and of the Scientific Council on Cardiomyopathies of the International Society. Br Heart J. 1994;71(3):215\u2013218. doi:10.1136\/hrt.71.3.215"},{"issue":"7","key":"i1526-6702-50-4-e227944-b4","series-title":"J Am Heart Assoc","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015016","article-title":"Right ventricular strain predicts structural disease progression in patients with arrhythmogenic right ventricular cardiomyopathy","volume":"9","author":"Malik\n              N","year":"2020","unstructured":"Malik\n              N\n            , WinS, JamesCA, et al.\n          Right ventricular strain predicts structural disease progression in patients with arrhythmogenic right ventricular cardiomyopathy. J Am Heart Assoc. 2020;9(7):e015016. doi:10.1161\/JAHA.119.015016"},{"issue":"11","key":"i1526-6702-50-4-e227944-b5","series-title":"Echocardiography","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1111\/echo.14716","article-title":"Presence and prognostic value of ventricular diastolic function in arrhythmogenic right ventricular cardiomyopathy","volume":"37","author":"Sadeghpour\n              A","year":"2020","unstructured":"Sadeghpour\n              A\n            , HosseiniL, RezaeianN, et al.\n          Presence and prognostic value of ventricular diastolic function in arrhythmogenic right ventricular cardiomyopathy. Echocardiography. 2020;37(11):1766\u20131773. doi:10.1111\/echo.14716"},{"issue":"5","key":"i1526-6702-50-4-e227944-b6","series-title":"Heart","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1136\/heart.83.5.588","article-title":"Arrhythmogenic right ventricular cardiomyopathy: diagnosis, prognosis, and treatment","volume":"83","author":"Corrado\n              D","year":"2000","unstructured":"Corrado\n              D\n            , BassoC, ThieneG. Arrhythmogenic right ventricular cardiomyopathy: diagnosis, prognosis, and treatment. Heart. 2000;83(5):588\u2013595. doi:10.1136\/heart.83.5.588"},{"issue":"7","key":"i1526-6702-50-4-e227944-b7","series-title":"Circ Cardiovasc Imaging","doi-asserted-by":"publisher","DOI":"10.1161\/HCI.0000000000000027","article-title":"2019 ACC\/AHA\/ASE key data elements and definitions for transthoracic echocardiography: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Clinical Data Standards for Transthoracic Echocardiography) and the American Society of Echocardiography","volume":"12","author":"Douglas\n              PS","year":"2019","unstructured":"Douglas\n              PS\n            , CarabelloBA, LangRM, et al.\n          2019 ACC\/AHA\/ASE key data elements and definitions for transthoracic echocardiography: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Clinical Data Standards for Transthoracic Echocardiography) and the American Society of Echocardiography. Circ Cardiovasc Imaging. 2019;12(7):e000027. doi:10.1161\/HCI.0000000000000027"},{"issue":"1","key":"i1526-6702-50-4-e227944-b8","series-title":"Eur Heart J Cardiovasc Imaging","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1093\/ehjci\/jew014","article-title":"Comparison of patients with early-phase arrhythmogenic right ventricular cardiomyopathy and right ventricular outflow tract ventricular tachycardia","volume":"18","author":"Saberniak\n              J","year":"2017","unstructured":"Saberniak\n              J\n            , LerenIS, HalandTF, et al.\n          Comparison of patients with early-phase arrhythmogenic right ventricular cardiomyopathy and right ventricular outflow tract ventricular tachycardia. Eur Heart J Cardiovasc Imaging. 2017;18(1):62\u201369. doi:10.1093\/ehjci\/jew014"},{"issue":"5","key":"i1526-6702-50-4-e227944-b9","series-title":"JACC Cardiovasc Imaging","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.jcmg.2016.06.011","article-title":"Combination of ECG and echocardiography for identification of arrhythmic events in early ARVC","volume":"10","author":"Leren\n              IS","year":"2017","unstructured":"Leren\n              IS\n            , SaberniakJ, HalandTF, EdvardsenT, HaugaaKH. Combination of ECG and echocardiography for identification of arrhythmic events in early ARVC. JACC Cardiovasc Imaging. 2017;10(5):503\u2013513. doi:10.1016\/j.jcmg.2016.06.011"},{"issue":"10","key":"i1526-6702-50-4-e227944-b10","series-title":"JACC Cardiovasc Imaging","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/j.jcmg.2018.05.017","article-title":"Prediction of life-threatening ventricular arrhythmia in patients with arrhythmogenic cardiomyopathy: a primary prevention cohort study","volume":"11","author":"Lie\n              \u00d8H","year":"2018","unstructured":"Lie\n              \u00d8H\n            , Rootwelt-NorbergC, DejgaardLA, et al.\n          Prediction of life-threatening ventricular arrhythmia in patients with arrhythmogenic cardiomyopathy: a primary prevention cohort study. JACC Cardiovasc Imaging. 2018;11(10):1377\u20131386. doi:10.1016\/j.jcmg.2018.05.017"},{"issue":"10","key":"i1526-6702-50-4-e227944-b11","series-title":"Heart Rhythm","doi-asserted-by":"publisher","first-page":"1964","DOI":"10.1016\/j.hrthm.2016.06.021","article-title":"Long-term right ventricular implantable cardioverter-defibrillator lead performance in arrhythmogenic right ventricular cardiomyopathy","volume":"13","author":"Herman\n              ARM","year":"2016","unstructured":"Herman\n              ARM\n            , GardnerM, SteinbergC, et al.\n          Long-term right ventricular implantable cardioverter-defibrillator lead performance in arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm. 2016;13(10):1964\u20131970. doi:10.1016\/j.hrthm.2016.06.021"},{"issue":"3","key":"i1526-6702-50-4-e227944-b12","series-title":"Int Heart J","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1536\/ihj.47.363","article-title":"Decrease in amplitude of intracardiac ventricular electrogram and inappropriate therapy in patients with an implantable cardioverter defibrillator","volume":"47","author":"Watanabe\n              H","year":"2006","unstructured":"Watanabe\n              H\n            , ChinushiM, IzumiD, et al.\n          Decrease in amplitude of intracardiac ventricular electrogram and inappropriate therapy in patients with an implantable cardioverter defibrillator. Int Heart J. 2006;47(3):363\u2013370. doi:10.1536\/ihj.47.363"},{"issue":"1","key":"i1526-6702-50-4-e227944-b13","series-title":"J Interv Card Electrophysiol","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s10840-014-9920-0","article-title":"Implantable cardioverter-defibrillators in patients with arrhythmogenic right ventricular cardiomyopathy: the course of electronic parameters, clinical features, and complications during long-term follow-up","volume":"41","author":"Mugnai\n              G","year":"2014","unstructured":"Mugnai\n              G\n            , TomeiR, DugoC, TomasiL, MoraniG, VassanelliC. Implantable cardioverter-defibrillators in patients with arrhythmogenic right ventricular cardiomyopathy: the course of electronic parameters, clinical features, and complications during long-term follow-up. J Interv Card Electrophysiol. 2014;41(1):23\u201329. doi:10.1007\/s10840-014-9920-0"},{"issue":"1","key":"i1526-6702-50-4-e227944-b14","series-title":"Int Heart J","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1536\/ihj.19-279","article-title":"Long-term performance of right ventricular implantable cardioverter-defibrillator leads in arrhythmogenic right ventricular cardiomyopathy and hypertrophic cardiomyopathy","volume":"61","author":"Sagawa\n              Y","year":"2020","unstructured":"Sagawa\n              Y\n            , NagataY, YamaguchiT, et al.\n          Long-term performance of right ventricular implantable cardioverter-defibrillator leads in arrhythmogenic right ventricular cardiomyopathy and hypertrophic cardiomyopathy. Int Heart J. 2020;61(1):39\u201345. doi:10.1536\/ihj.19-279"},{"issue":"4","key":"i1526-6702-50-4-e227944-b15","series-title":"Am Heart J","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/0002-8703(94)90103-1","article-title":"Implantable cardioverter defibrillator therapy in patients with arrhythmogenic right ventricular cardiomyopathy, long QT syndrome, or no structural heart disease","volume":"127","author":"Breithardt\n              G","year":"1994","unstructured":"Breithardt\n              G\n            , WichterT, HaverkampW, et al.\n          Implantable cardioverter defibrillator therapy in patients with arrhythmogenic right ventricular cardiomyopathy, long QT syndrome, or no structural heart disease. Am Heart J. 1994;127(4):1151\u20131158. doi:10.1016\/0002-8703(94)90103-1"}],"container-title":["Texas Heart Institute Journal"],"original-title":[],"link":[{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/50\/4\/article-e227944.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/thij\/article-pdf\/doi\/10.14503\/THIJ-22-7944\/3411990\/i1526-6702-50-4-e227944.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/50\/4\/article-e227944.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/50\/4\/article-e227944.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:33:46Z","timestamp":1730993626000},"score":1,"resource":{"primary":{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/50\/4\/article-e227944.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,24]]},"references-count":15,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.14503\/thij-22-7944","relation":{},"ISSN":["1526-6702","0730-2347"],"issn-type":[{"value":"1526-6702","type":"electronic"},{"value":"0730-2347","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,24]]}}}