{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T16:10:22Z","timestamp":1730995822114,"version":"3.28.0"},"reference-count":10,"publisher":"Texas Heart Institute Journal","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:sec>\n          <jats:title>Background:<\/jats:title>\n          <jats:p>Atrial tachyarrhythmias are common and difficult to treat in adults with congenital heart disease. Dronedarone has proven effective in patients without congenital heart disease, but data are limited about its use in adults with congenital heart disease of moderate to great complexity.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Methods:<\/jats:title>\n          <jats:p>A single-center, retrospective chart review of 21 adults with congenital heart disease of moderate to great complexity who were treated with dronedarone for atrial tachyarrhythmias was performed.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Results:<\/jats:title>\n          <jats:p>The median (IQR) age at dronedarone initiation was 35 (27.5-39) years. Eleven patients (52%) were male. Ten patients (48%) had New York Heart Association class I disease, 10 (48%) had class II disease, and 1 (5%) had class III disease. Ejection fraction at initiation was greater than 55% in 11 patients (52%), 35% to 55% in 9 patients (43%), and less than 35% in 1 patient (5%). Prior treatments included \u03b2-blockers (71%), sotalol (38%), amiodarone (24%), digoxin (24%), and catheter ablation (38%). Rhythm control was complete in 5 patients (24%), partial in 6 (29%), and inadequate in 10 (48%). Two patients (10%) experienced adverse events, including nausea in 1 (5%) and cardiac arrest in 1 (5%), which occurred 48 months after initiation of treatment. There were no deaths during the follow-up period. The median (IQR) follow-up time for patients with complete or partial rhythm control was 20 (1-54) months.<\/jats:p>\n        <\/jats:sec>\n        <jats:sec>\n          <jats:title>Conclusion:<\/jats:title>\n          <jats:p>Dronedarone can be effective for adult patients with congenital heart disease and atrial arrhythmias for whom more established therapies have failed, and with close monitoring it can be safely tolerated.<\/jats:p>\n        <\/jats:sec>","DOI":"10.14503\/thij-22-7993","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T09:08:09Z","timestamp":1714468089000},"source":"Crossref","is-referenced-by-count":0,"title":["Dronedarone for the Treatment of Atrial Arrhythmias in Adults With Congenital Heart Disease"],"prefix":"10.14503","volume":"51","author":[{"given":"Mahdi S.","family":"Agha","sequence":"first","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Ermis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Baylor College of Medicine, Houston, Texas"},{"name":"Department of Medicine, Division of Cardiology, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne J.","family":"Franklin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, The University of Arizona College of Medicine, Phoenix, Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhaval R.","family":"Parekh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Baylor College of Medicine, Houston, Texas"},{"name":"Department of Medicine, Division of Cardiology, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeline D.","family":"Opina","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Baylor College of Medicine, Houston, Texas"},{"name":"Department of Medicine, Division of Cardiology, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina Y.","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago O.","family":"Valdes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson W.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Cardiology, Baylor College of Medicine, Houston, Texas"},{"name":"Department of Medicine, Division of Cardiology, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"4","key":"b1","series-title":"Circulation","first-page":"534","article-title":"Arrhythmias in adult patients with congenital heart disease","volume":"115","author":"Walsh\n              EP","year":"2007","unstructured":"Walsh\n              EP\n            , CecchinF. Arrhythmias in adult patients with congenital heart disease. Circulation. 2007;115(4):534-545. doi:10.1161\/CIRCULATIONAHA.105.592410"},{"issue":"7","key":"b2","series-title":"Kardiologiia","first-page":"58","article-title":"Efficacy of dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter. Results of the EURIDIS and ADONIS. Article in Russian","volume":"48","author":"Preobrazhenski\u012d\n              DV","year":"2008","unstructured":"Preobrazhenski\u012d\n              DV\n            \n          . Efficacy of dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter. Results of the EURIDIS and ADONIS. Article in Russian. Kardiologiia. 2008;48(7):58-59."},{"issue":"25","key":"b3","series-title":"N Engl J Med","first-page":"2678","article-title":"Increased mortality after dronedarone therapy for severe heart failure","volume":"358","author":"K\u00f8ber\n              L","year":"2008","unstructured":"K\u00f8ber\n              L\n            , Torp-PedersenC, McMurrayJJV, et al; Dronedarone Study Group. Increased mortality after dronedarone therapy for severe heart failure. N Engl J Med. 2008;358(25):2678-2687. doi:10.1056\/NEJMoa0800456"},{"issue":"10","key":"b4","series-title":"Heart Rhythm","first-page":"e102","article-title":"PACES\/HRS expert consensus statement on the recognition and management of arrhythmias in adult congenital heart disease: developed in partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Endorsed by the governing bodies of PACES, HRS, the American College of Cardiology (ACC), the American Heart Association (AHA), the European Heart Rhythm Association (EHRA), the Canadian Heart Rhythm Society (CHRS), and the International Society for Adult Congenital Heart Disease (ISACHD)","volume":"11","author":"Khairy\n              P","year":"2014","unstructured":"Khairy\n              P\n            , Van HareGF, BalajiS, et al.\n          PACES\/HRS expert consensus statement on the recognition and management of arrhythmias in adult congenital heart disease: developed in partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Endorsed by the governing bodies of PACES, HRS, the American College of Cardiology (ACC), the American Heart Association (AHA), the European Heart Rhythm Association (EHRA), the Canadian Heart Rhythm Society (CHRS), and the International Society for Adult Congenital Heart Disease (ISACHD). Heart Rhythm. 2014;11(10):e102-e165. doi:10.1016\/j.hrthm.2014.05.009"},{"issue":"12","key":"b5","series-title":"J Am Coll Cardiol","first-page":"1494","article-title":"2018 AHA\/ACC guideline for the management of adults with congenital heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"73","author":"Stout\n              KK","year":"2019","unstructured":"Stout\n              KK\n            , DanielsCJ, AboulhosnJA, et al.\n          2018 AHA\/ACC guideline for the management of adults with congenital heart disease: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019;73(12):1494-1563. doi:10.1016\/j.jacc.2018.08.1028"},{"issue":"6","key":"b6","series-title":"Congenit Heart Dis","first-page":"944","article-title":"Adverse effects of amiodarone therapy in adults with congenital heart disease","volume":"13","author":"Moore\n              BM","year":"2018","unstructured":"Moore\n              BM\n            , CordinaRL, McGuireMA, CelermajerDS. Adverse effects of amiodarone therapy in adults with congenital heart disease. Congenit Heart Dis. 2018;13(6):944-951. doi:10.1111\/chd.12657"},{"issue":"10","key":"b7","series-title":"Heart Rhythm","first-page":"2034","article-title":"Use of dofetilide in adult patients with atrial arrhythmias and congenital heart disease: a PACES collaborative study","volume":"13","author":"El-Assaad\n              I","year":"2016","unstructured":"El-Assaad\n              I\n            , Al-KindiSG, AbrahamJE, et al.\n          Use of dofetilide in adult patients with atrial arrhythmias and congenital heart disease: a PACES collaborative study. Heart Rhythm. 2016;13(10):2034-2039. doi:10.1016\/j.hrthm.2016.07.016"},{"issue":"3","key":"b8","series-title":"Congenit Heart Dis","first-page":"221","article-title":"Clinical efficacy of dofetilide for the treatment of atrial tachyarrhythmias in adults with congenital heart disease","volume":"9","author":"Banchs\n              JE","year":"2014","unstructured":"Banchs\n              JE\n            , BaqueroGA, NickolausMJ, et al.\n          Clinical efficacy of dofetilide for the treatment of atrial tachyarrhythmias in adults with congenital heart disease. Congenit Heart Dis. 2014;9(3):221-227. doi:10.1111\/chd.12129"},{"issue":"10","key":"b9","series-title":"Pacing Clin Electrophysiol","first-page":"1313","article-title":"Dofetilide for atrial arrhythmias in congenital heart disease: a multicenter study","volume":"32","author":"Wells\n              R","year":"2009","unstructured":"Wells\n              R\n            , KhairyP, HarrisL, AndersonCC, BalajiS. Dofetilide for atrial arrhythmias in congenital heart disease: a multicenter study. Pacing Clin Electrophysiol. 2009;32(10):1313-1318. doi:10.1111\/j.1540-8159.2009.02479.x"},{"issue":"7","key":"b10","series-title":"N Engl J Med","first-page":"668","article-title":"Effect of dronedarone on cardiovascular events in atrial fibrillation","volume":"360","author":"Hohnloser\n              SH","year":"2009","unstructured":"Hohnloser\n              SH\n            , CrijnsHJGM, van EickelsM, et al; ATHENA Investigators. Effect of dronedarone on cardiovascular events in atrial fibrillation. N Engl J Med. 2009;360(7):668-678. doi:10.1056\/NEJMoa0803778"}],"container-title":["Texas Heart Institute Journal"],"original-title":[],"link":[{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/51\/1\/article-e227993.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/thij\/article-pdf\/doi\/10.14503\/THIJ-22-7993\/3411023\/i1526-6702-51-1-e227993.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/51\/1\/article-e227993.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/51\/1\/article-e227993.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:38:07Z","timestamp":1730993887000},"score":1,"resource":{"primary":{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/51\/1\/article-e227993.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":10,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.14503\/thij-22-7993","relation":{},"ISSN":["1526-6702","0730-2347"],"issn-type":[{"type":"electronic","value":"1526-6702"},{"type":"print","value":"0730-2347"}],"subject":[],"published":{"date-parts":[[2024]]}}}