{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T12:34:03Z","timestamp":1770467643864,"version":"3.49.0"},"reference-count":9,"publisher":"Texas Heart Institute Journal","issue":"2","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:title>Abstract<\/jats:title>\n        <jats:p>Whipple disease is a rare systemic illness associated with weight loss, diarrhea, and arthralgia. Asymptomatic carriage is common, but the disease can be complicated by cardiac involvement and may result in culture-negative endocarditis. Cardiac manifestations of the disease can lead to death. This report presents the case of a 66-year-old man with Whipple disease and biventricular heart failure with cardiogenic shock. Medical therapy followed by successful replacement of the aortic and mitral valves resulted in substantial improvement.<\/jats:p>","DOI":"10.14503\/thij-23-8336","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T09:01:38Z","timestamp":1722848498000},"source":"Crossref","is-referenced-by-count":1,"title":["Valvular Endocarditis and Biventricular Heart Failure in the Setting of Tropheryma whipplei Disease"],"prefix":"10.14503","volume":"51","author":[{"given":"Defne Gunes","family":"Ergi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hind J.","family":"Fadel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector I.","family":"Michelena","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin L.","family":"Greason","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arman","family":"Arghami","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"3","key":"b1","series-title":"Lancet Infect Dis","first-page":"e13","article-title":"Tropheryma whipplei infection and Whipple's disease","volume":"16","author":"Marth\n              T","year":"2016","unstructured":"Marth\n              T\n            , MoosV, M\u00fcllerC, BiagiF, SchneiderT.\n          \n            Tropheryma whipplei infection and Whipple's disease. Lancet Infect Dis. 2016;16(3):e13\u2013e22. doi:10.1016\/S1473-3099(15)00537-X"},{"issue":"4","key":"b2","series-title":"Eur Heart J Case Rep","first-page":"1","article-title":"Whipple's endocarditis: a case report of a blood culture-negative endocarditis","volume":"3","author":"Scheurwater\n              MA","year":"2019","unstructured":"Scheurwater\n              MA\n            , VerduinCM, van DantzigJM.\n          Whipple's endocarditis: a case report of a blood culture-negative endocarditis. Eur Heart J Case Rep. 2019;3(4):1\u20136. doi:10.1093\/ehjcr\/ytz222"},{"issue":"12","key":"b3","series-title":"Am J Med","first-page":"1364","article-title":"Tropheryma whipplei endocarditis: a two-patient case series","volume":"128","author":"Borne\n              RT","year":"2015","unstructured":"Borne\n              RT\n            , BabuA, LeviM, BriekeA, QuaifeRA.\n          \n            Tropheryma whipplei endocarditis: a two-patient case series. Am J Med. 2015;128(12):1364\u20131366. doi:10.1016\/j.amjmed.2015.06.053"},{"issue":"2","key":"b4","series-title":"J Clin Microbiol","first-page":"216","article-title":"High frequency of Tropheryma whipplei in culture-negative endocarditis","volume":"50","author":"Geissd\u00f6rfer\n              W","year":"2012","unstructured":"Geissd\u00f6rfer\n              W\n            , MoosV, MoterA, et al.\n          High frequency of Tropheryma whipplei in culture-negative endocarditis. J Clin Microbiol. 2012;50(2):216\u2013222. doi:10.1128\/JCM.05531-11"},{"issue":"2","key":"b5","series-title":"Am J Med","first-page":"263","article-title":"Severe pulmonary hypertension in a patient with Whipple's disease","volume":"79","author":"Morrison\n              DA","year":"1985","unstructured":"Morrison\n              DA\n            , GayRG, FeldshonD, SamplinerRE.\n          Severe pulmonary hypertension in a patient with Whipple's disease. Am J Med. 1985;79(2):263\u2013267. doi:10.1016\/0002-9343(85)90020-8"},{"issue":"2","key":"b6","series-title":"Clin Immunol Immunopathol","first-page":"217","article-title":"Persistent reduction of complement receptor 3 alpha-chain expressing mononuclear blood cells and transient inhibitory serum factors in Whipple's disease","volume":"72","author":"Marth\n              T","year":"1994","unstructured":"Marth\n              T\n            , RouxM, von HerbayA, MeuerSC, FeurleGE.\n          Persistent reduction of complement receptor 3 alpha-chain expressing mononuclear blood cells and transient inhibitory serum factors in Whipple's disease. Clin Immunol Immunopathol. 1994;72(2):217\u2013226. doi:10.1006\/clin.1994.1134"},{"issue":"2","key":"b7","series-title":"Eur Respir J","first-page":"2002341","article-title":"Targeting transforming growth factor-\u03b2 receptors in pulmonary hypertension","volume":"57","author":"Guignabert\n              C","year":"2021","unstructured":"Guignabert\n              C\n            , HumbertM.\n          Targeting transforming growth factor-\u03b2 receptors in pulmonary hypertension. Eur Respir J. 2021;57(2):2002341. doi:10.1183\/13993003.02341-2020"},{"issue":"suppl 1","key":"b8","series-title":"Open Forum Infect Dis","first-page":"S407","article-title":"710. Non-invasive diagnosis of Whipple endocarditis using next-generation sequencing for microbial cell-free DNA in plasma","volume":"7","author":"de Vries\n              CR","year":"2020","unstructured":"de Vries\n              CR\n            , MacintyreA, BuggyB.\n          710. Non-invasive diagnosis of Whipple endocarditis using next-generation sequencing for microbial cell-free DNA in plasma. Open Forum Infect Dis. 2020;7(suppl 1):S407. doi.org\/10.1093\/ofid\/ofaa439.902"},{"issue":"1","key":"b9","series-title":"Interact Cardiovasc Thorac Surg","first-page":"161","article-title":"Tropheryma whipplei endocarditis without gastrointestinal involvement","volume":"15","author":"Love\n              SM","year":"2012","unstructured":"Love\n              SM\n            , MorrisonL, ApplebyC, ModiP.\n          \n            Tropheryma whipplei endocarditis without gastrointestinal involvement. Interact Cardiovasc Thorac Surg. 2012;15(1):161\u2013163. doi:10.1093\/icvts\/ivs116"}],"container-title":["Texas Heart Institute Journal"],"original-title":[],"link":[{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/51\/2\/article-e238336.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/thij\/article-pdf\/doi\/10.14503\/THIJ-23-8336\/3414252\/i1526-6702-51-2-e238336.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/51\/2\/article-e238336.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thij.kglmeridian.com\/downloadpdf\/journals\/thij\/51\/2\/article-e238336.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:38:58Z","timestamp":1730993938000},"score":1,"resource":{"primary":{"URL":"https:\/\/thij.kglmeridian.com\/view\/journals\/thij\/51\/2\/article-e238336.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":9,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.14503\/thij-23-8336","relation":{},"ISSN":["1526-6702","0730-2347"],"issn-type":[{"value":"1526-6702","type":"electronic"},{"value":"0730-2347","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}