{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T04:13:13Z","timestamp":1748491993790,"version":"3.41.0"},"reference-count":10,"publisher":"Texas Heart Institute Journal","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Platypnea-orthodeoxia syndrome is a rare condition characterized by positional dyspnea and hypoxemia, with symptoms presenting in the upright position and improving when recumbent. Hypoxemia in platypnea-orthodeoxia syndrome is defined as a drop in Pao<jats:sub>2<\/jats:sub> of more than 4 mm Hg or oxygen saturation greater than 5% when moving from a supine to an upright position. Etiologic mechanisms include intracardiac or pulmonary shunts and ventilation perfusion ratio mismatch. Platypnea-orthodeoxia syndrome has been described as part of COVID-19 pneumonia sequelae, with differing physiologic mechanisms from cardiac pathologies. This report presents the case of a patient with platypnea-orthodeoxia syndrome of multifactorial etiology: intracardiac shunting secondary to a patent foramen ovale and ventilation perfusion ratio mismatch as a sequela of COVID-19 pneumonia.<\/jats:p>","DOI":"10.14503\/thij-24-8401","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:01:16Z","timestamp":1748476876000},"source":"Crossref","is-referenced-by-count":0,"title":["Platypnea-Orthodeoxia and Patent Foramen Ovale in a Patient in the Setting of COVID-19"],"prefix":"10.14503","volume":"52","author":[{"given":"Laura","family":"Sarmiento","sequence":"first","affiliation":[{"name":"Department of Medicine, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riyad","family":"Kherallah","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Baylor College of Medicine, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme","family":"Vianna Silva","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology, Department of Internal Medicine, Baylor St Luke's Medical Center, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5628","reference":[{"issue":"5","key":"b1","series-title":"Tex Heart Inst J","doi-asserted-by":"publisher","first-page":"498","DOI":"10.14503\/THIJ-14-4596","article-title":"Platypnea-orthodeoxia syndrome: diagnostic challenge and the importance of heightened clinical suspicion","volume":"42","author":"Henkin S","year":"2015","unstructured":"Henkin S, Negrotto S, Pollak PM, Cullen MW, O\u2019Cochlain DF, Wright RS. 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BMJ Case Rep. 2021;14(5):e243016. doi:10.1136\/bcr-2021-243016"},{"issue":"10","key":"b8","series-title":"Cureus","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.10958","article-title":"Patent foramen ovale with platypnea-orthodeoxia syndrome: a case report","volume":"12","author":"Mirwais S","year":"2020","unstructured":"Mirwais S, Mirwais M, Altaf A, Collins J. Patent foramen ovale with platypnea-orthodeoxia syndrome: a case report. Cureus. 2020;12(10):e10958. doi:10.7759\/cureus.10958"},{"issue":"5","key":"b9","series-title":"Echocardiography","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1111\/j.1540-8175.2008.00852.x","article-title":"Patent foramen ovale: comparison among diagnostic strategies in cryptogenic stroke and migraine","volume":"26","author":"Zito C","year":"2009","unstructured":"Zito C, Dattilo G, Oreto G, et al. Patent foramen ovale: comparison among diagnostic strategies in cryptogenic stroke and migraine. 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