{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:40:50Z","timestamp":1780605650130,"version":"3.54.1"},"reference-count":9,"publisher":"Texas Heart Institute Journal","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>A 63-year-old man with a history of hypertension, prediabetes, and sleep apnea presented with pedal edema, weight loss, and flushing. Laboratory work revealed elevated B-type natriuretic peptide and normocytic anemia. Echocardiography showed right ventricular enlargement, severe tricuspid valve regurgitation, and thickened tricuspid valve leaflets, raising suspicion for carcinoid heart disease. Further testing confirmed a neuroendocrine tumor with liver metastasis. Despite somatostatin therapy, the patient's symptoms were refractory to diuretics. Surgical intervention with tricuspid and pulmonary valve replacement was undertaken. Postoperatively, the patient demonstrated substantial improvement in functional tolerance and quality of life. This case highlights the importance of surgical intervention in advanced carcinoid heart disease.<\/jats:p>","DOI":"10.14503\/thij-25-8599","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:02:18Z","timestamp":1752105738000},"source":"Crossref","is-referenced-by-count":1,"title":["Complex Tricuspid and Pulmonic Carcinoid Heart Disease With Timely Surgical Repair"],"prefix":"10.14503","volume":"52","author":[{"given":"John","family":"Hollowed","sequence":"first","affiliation":[{"name":"Division of Cardiology, University of California, Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hawkin","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon","family":"Hamburg","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology, University of California, Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Ardehali","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, University of California, Los Angeles, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5628","reference":[{"issue":"11","key":"b1","series-title":"ESMO Open","first-page":"103959","article-title":"Carcinoid heart disease in patients with advanced small-intestinal neuroendocrine tumors and carcinoid syndrome: a retrospective experience from two European referral centers","volume":"9","author":"Algeri L","year":"2024","unstructured":"Algeri L, Falkman L, Spada F, et al. Carcinoid heart disease in patients with advanced small-intestinal neuroendocrine tumors and carcinoid syndrome: a retrospective experience from two European referral centers. ESMO Open. 2024;9(11):103959. doi:10.1016\/j.esmoop.2024.103959"},{"issue":"5","key":"b2","series-title":"Braz J Cardiovasc Surg","first-page":"400","article-title":"Valvular disorders in carcinoid heart disease","volume":"31","author":"Yuan SM","year":"2016","unstructured":"Yuan SM. Valvular disorders in carcinoid heart disease. Braz J Cardiovasc Surg. 2016;31(5):400-405. doi:10.5935\/1678-9741.20160079"},{"issue":"4","key":"b3","series-title":"Circulation","first-page":"790","article-title":"Carcinoid heart disease. Correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography","volume":"92","author":"Robiolio PA","year":"1995","unstructured":"Robiolio PA, Rigolin VH, Wilson JS, et al. Carcinoid heart disease. Correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography. Circulation. 1995;92(4):790-795. doi:10.1161\/01.cir.92.4.790"},{"issue":"10","key":"b4","series-title":"J Am Coll Cardiol","first-page":"1288","article-title":"Diagnosing and managing carcinoid heart disease in patients with neuroendocrine tumors: an expert statement","volume":"69","author":"Davar J","year":"2017","unstructured":"Davar J, Connolly HM, Caplin ME, et al. Diagnosing and managing carcinoid heart disease in patients with neuroendocrine tumors: an expert statement. J Am Coll Cardiol. 2017;69(10):1288-1304. doi:10.1016\/j.jacc.2016.12.030"},{"issue":"11","key":"b5","series-title":"N Engl J Med","first-page":"1005","article-title":"Factors associated with progression of carcinoid heart disease","volume":"348","author":"M\u00f8ller JE","year":"2003","unstructured":"M\u00f8ller JE, Connolly HM, Rubin J, Seward JB, Modesto K, Pellikka PA. 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Circulation. 2005;112(21):3320-3327. doi:10.1161\/CIRCULATIONAHA.105.553750"},{"issue":"20","key":"b8","series-title":"J Am Coll Cardiol","first-page":"2189","article-title":"Early and late outcomes of surgical treatment in carcinoid heart disease","volume":"66","author":"Connolly HM","year":"2015","unstructured":"Connolly HM, Schaff HV, Abel MD, et al. Early and late outcomes of surgical treatment in carcinoid heart disease. J Am Coll Cardiol. 2015;66(20):2189-2196. doi:10.1016\/j.jacc.2015.09.014"},{"issue":"6","key":"b9","series-title":"Pancreas","first-page":"707","article-title":"The North American Neuroendocrine Tumor Society consensus guidelines for surveillance and medical management of midgut neuroendocrine tumors","volume":"46","author":"Strosberg JR","year":"2017","unstructured":"Strosberg JR, Halfdanarson TR, Bellizzi AM. The North American Neuroendocrine Tumor Society consensus guidelines for surveillance and medical management of midgut neuroendocrine tumors. 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