{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T20:41:44Z","timestamp":1785789704474,"version":"3.56.0"},"reference-count":24,"publisher":"Korean Epilepsy Society","issue":"2","content-domain":{"domain":["j-epilepsy.org"],"crossmark-restriction":true},"short-container-title":["J Epilepsy Res"],"abstract":"<jats:p>Background and Purpose: The timeline of alteration of vitamin D and calcium levels in those receiving anti-seizure medication (ASM) remains to be elucidated. To determine the changes in vitamin D levels over a period of 6 months among children receiving monotherapy with commonly used ASM.Methods: The baseline serum levels of vitamin D, parathyroid hormone (PTH), calcium, alkaline phosphatase (ALP), phosphorus were measured in 32 children (median age 8 years) with newly diagnosed epilepsy. An appropriate ASM monotherapy was started. Those found to be deficient were treated with vitamin D supplementation. Children were reassessed after 90 days and 180 days for drug compliance and drug side-effects. All the baseline investigations were repeated.Results: At baseline, 21.9% of children were vitamin D-deficient, with a median serum level of 19.8 ng\/mL. For children who were not vitamin D-deficient (VDD) at baseline (n=25), the median (interquartile range [IQR]) vitamin D levels were found to be significantly lower than baseline after 90 days of ASM use (23.0 [18.0 to 28.9] vs. 22.0 [12.0 to 24.0]; &lt;i&gt;p&lt;\/i&gt;&lt;0.001). After 90 days, ASMs caused notable decreases in vitamin D levels from baseline for children who were not VDD at baseline (n=25) (23.0 [18.0 to 28.9] vs. 22.0 [12.0 to 24.0]; &lt;i&gt;p&lt;\/i&gt;&lt;0.001), alongside changes in calcium, phosphorus, PTH and ALP levels. Similarly, in children who were non-deficient at 90 days follow-up (n=20), median (IQR) vitamin D levels were found to be significantly lower at 180 days than at 90 days (24.5 [21.0 to 28.9] vs. 18.4 [13.6 to 20.6]; &lt;i&gt;p&lt;\/i&gt;&lt;0.001).Conclusions: The study noted vitamin D deficiency in children on ASM monotherapy for 3-6 months, emphasizing regular monitoring by clinicians.<\/jats:p>","DOI":"10.14581\/jer.24013","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:15:13Z","timestamp":1733876113000},"page":"73-80","update-policy":"https:\/\/doi.org\/10.14581\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Anti-Seizure Medication Monotherapy on Vitamin D Levels in Indian Children: A Longitudinal Cohort 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estimation of areas of burns","author":"Lund","year":"1944"},{"key":"ref14","first-page":"53","volume-title":"The 2011 report on dietary reference intakes for calcium and vitamin D from the institute of medicine: what clinicians need to know","author":"Ross","year":"2011"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000443136"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-014-0428-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2010.05.013"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-021-02906-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13443"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-21279-0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4863.192338"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/nu6020729"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.4.1097s"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-421"}],"container-title":["Journal of Epilepsy 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