{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:04:04Z","timestamp":1783595044011,"version":"3.55.0"},"reference-count":23,"publisher":"Korean Epilepsy Society","issue":"2","content-domain":{"domain":["j-epilepsy.org"],"crossmark-restriction":true},"short-container-title":["J Epilepsy Res"],"abstract":"<jats:p>Background and Purpose: Epilepsy increases poor outcomes in patients with post-traumatic brain injury and brain tumor-related epilepsy, for whom early seizure control is essential. Perampanel (PER) was a known third-generation antiepileptic drug for treatment all types of seizures. The objective of the study is to compare clinical outcomes and safety of PER administration as monotherapy.Methods: A prospective study of all 84 patients assigned to PER monotherapy (PER group, n=36) and other first-line antiepileptic drugs (n=48). Clinical outcomes parameters were measured by the prevalence of patients with a diminish in seizure frequency at 50% in 28 days. From November 1, 2020 to April 30, 2024, comparing the PER group with usual care. Clinical outcomes included adherence rate and seizure-free proportion at 28 days and 6 months. Adverse drug reactions were recorded in both groups.Results: There was no difference in demographic data and incidence of adverse drug reactions between two groups. Median PER dosage was 4 mg (range, 2-12 mg). Compared to other antiepileptic drugs, the PER group had a prevalence of 50% responder rate at 28 days and 6 months significantly were 75%, 81%, 65%, and 51% respectively. Common adverse drug reactions were somnolence and dizziness.Conclusions: PER administration as monotherapy demonstrated good efficacy and less adverse drug reactions. Low dosages helped to decrease adverse drug reactions andimproved retention rate.<\/jats:p>","DOI":"10.14581\/jer.24014","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:15:13Z","timestamp":1733876113000},"page":"81-93","update-policy":"https:\/\/doi.org\/10.14581\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Perampanel for First-Episode Seizures versus Usual Care on Clinical Outcome and Safety Profile Aspects of the Thai Experience"],"prefix":"10.14581","volume":"14","author":[{"given":"Panu","family":"Boontoterm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siraruj","family":"Sakoolnamarka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karanarak","family":"Urasyanandana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pusit","family":"Fuengfoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5688","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebcr.2017.11.001"},{"key":"ref2","first-page":"589","volume-title":"Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304","author":"French","year":"2012"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03638.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.106655"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.12.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2006.06.003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90630-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2174\/157015909788848866"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12555"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1981.tb04327.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.04501.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.3949"},{"key":"ref13","first-page":"81","volume-title":"Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. 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