{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:38:27Z","timestamp":1791333507888,"version":"4.3.1"},"reference-count":33,"publisher":"Korean Epilepsy Society","issue":"2","content-domain":{"domain":["j-epilepsy.org"],"crossmark-restriction":true},"short-container-title":["J Epilepsy Res"],"abstract":"<jats:p>Lance Adams syndrome (LAS) is characterized by chronic action or intention myoclonus resulting from cerebral hypoxia. Perampanel, a non-competitive antagonist of aamino-3-hydroxy-5methyl-4 isooxazoleproprionic acid glutamate receptor, has demonstrated some efficacy in myoclonic epilepsy and other types of myoclonus. We report significant benefit in a patient with LAS treated with add on perampanel and provide a review of the relevant literature. In our case, a male patient in his 30s was found pulseless with unknown down time. The patient developed post anoxic myoclonus within 1 week from cardiac arrest. Patient continued to suffer from intractable myoclonus despite being treated with brivaracetam, valproic acid, and clonazepam. Perampanel was added to his medication regimen and up-titrated to 12 mg daily over 1-2 weeks. This resulted in significant improvement in frequency and severity of myoclonus for about 6 months. Growing evidence exists for perampanel as an adjunctive treatment in patients with post hypoxic myoclonus or LAS. A review of the available literature, comprised of case reports and case series, and suggests a potential role for perampanel in patients with LAS. Further study is warranted including controlled trials of perampanel use in post hypoxic myoclonus.<\/jats:p>","DOI":"10.14581\/jer.24016","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:15:13Z","timestamp":1733876113000},"page":"97-101","update-policy":"https:\/\/doi.org\/10.14581\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Use of Perampanel in the Treatment of Lance-Adams Syndrome"],"prefix":"10.14581","volume":"14","author":[{"given":"Vishal","family":"Pandya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil 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