{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T08:11:55Z","timestamp":1773648715204,"version":"3.50.1"},"reference-count":25,"publisher":"Pacini Editore","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Otorhinolaryngol Ital"],"DOI":"10.14639\/0392-100x-a878","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:35:09Z","timestamp":1773315309000},"page":"23-33","source":"Crossref","is-referenced-by-count":0,"title":["Beyond sentinel node biopsy: preliminary results of indocyanine green-guided neck dissection in cN0 tongue cancer"],"prefix":"10.14639","volume":"46","author":[{"given":"Luca","family":"Calabrese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Gazzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Tagliabue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Fazio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guglielmo","family":"Ronzani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Bruschini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Navach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Camesasca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohssen","family":"Ansarin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monir","family":"Abousiam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20340","published-online":{"date-parts":[[2026,2]]},"reference":[{"key":"10.14639\/0392-100X-A878_ref1","doi-asserted-by":"crossref","unstructured":"Cerezo L, Mill\u00e1n I, Torre A, et al. Prognostic factors for survival and tumor control in cervical lymph node metastases from head and neck cancer. A multivariate study of 492 cases. Cancer 69:1224-1234, 1992. https:\/\/doi.org\/10.1002\/cncr.2820690526","DOI":"10.1002\/cncr.2820690526"},{"key":"10.14639\/0392-100X-A878_ref2","doi-asserted-by":"crossref","unstructured":"Hutchison IL, Ridout F, Cheung SMY, et al. Nationwide randomised trial evaluating elective neck dissection for early stage oral cancer (SEND study) with meta-analysis and concurrent real-world cohort. Br J Cancer 2019;121:827-836. https:\/\/doi.org\/10.1038\/s41416-019-0587-2","DOI":"10.1038\/s41416-019-0587-2"},{"key":"10.14639\/0392-100X-A878_ref3","doi-asserted-by":"crossref","unstructured":"Greenberg JS, El Naggar AK, Mo V, et al. Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma. Implication for therapeutic decision making. Cancer 2003;98:508-515. https:\/\/doi.org\/10.1002\/cncr.11526","DOI":"10.1002\/cncr.11526"},{"key":"10.14639\/0392-100X-A878_ref4","doi-asserted-by":"crossref","unstructured":"Abu-Ghanem S, Yehuda M, Carmel N-N, et al. Elective neck dissection vs observation in early-stage squamous cell carcinoma of the oral tongue with no clinically apparent lymph node metastasis in the neck: a systematic review and meta-analysis. JAMA Otolaryngol Head Neck Surg 2016;142:857-865. https:\/\/doi:10.1001\/jamaoto.2016.1281","DOI":"10.1001\/jamaoto.2016.1281"},{"key":"10.14639\/0392-100X-A878_ref5","doi-asserted-by":"crossref","unstructured":"Samant S, Robbins KT. Evolution of neck dissection for improved functional outcome. World J Surg 2003;27:805-810. https:\/\/doi.org\/10.1007\/s00268-003-7113-6","DOI":"10.1007\/s00268-003-7113-6"},{"key":"10.14639\/0392-100X-A878_ref6","doi-asserted-by":"crossref","unstructured":"Shah JP, Andersen PE. The impact of patterns of nodal metastasis on modifications of neck dissection. Ann Surg Oncol 1994;1:521-532. https:\/\/doi.org\/10.1007\/BF02303619","DOI":"10.1007\/BF02303619"},{"key":"10.14639\/0392-100X-A878_ref7","doi-asserted-by":"crossref","unstructured":"Shah JP, Candela FC, Poddar AK. The patterns of cervical lymph node metastases from squamous carcinoma of the oral cavity. Cancer 1990;66:109-113. https:\/\/doi.org\/10.1002\/1097-0142(19900701)66:1<109::aid-cncr2820660120>3.0.co;2-a.","DOI":"10.1002\/1097-0142(19900701)66:1<109::AID-CNCR2820660120>3.0.CO;2-A"},{"key":"10.14639\/0392-100X-A878_ref8","doi-asserted-by":"crossref","unstructured":"Ferreli F, Festa BM, Costantino A, et al. Prevalence of occult level 2b nodal metastases in cN0 squamous cell carcinoma of the oral cavity: a systematic review and meta-analysis. Oral Oncol 2021;122:105540. https:\/\/doi.org\/10.1016\/j.oraloncology.2021.105540","DOI":"10.1016\/j.oraloncology.2021.105540"},{"key":"10.14639\/0392-100X-A878_ref9","doi-asserted-by":"crossref","unstructured":"Feng Z, Li JN, Niu LX, et al. Supraomohyoid neck dissection in the management of oral squamous cell carcinoma: special consideration for skip metastases at level IV or V. J Oral Maxillofac Surg 2014;72:1203-1211. https:\/\/doi.org\/10.1016\/j.joms.2013.12.008","DOI":"10.1016\/j.joms.2013.12.008"},{"key":"10.14639\/0392-100X-A878_ref10","doi-asserted-by":"crossref","unstructured":"Holden AM, Sharma D, Schilling C, et al. Biopsy of the sentinel lymph node in oral squamous cell carcinoma: analysis of error in 100 consecutive cases. Br J Oral Maxillofac Surg 2018;56:615-620. https:\/\/doi.org\/10.1016\/j.bjoms.2018.06.019","DOI":"10.1016\/j.bjoms.2018.06.019"},{"key":"10.14639\/0392-100X-A878_ref11","doi-asserted-by":"crossref","unstructured":"Galimberti V, Cole BF, Viale G, et al. Axillary dissection versus no axillary dissection in patients with breast cancer and sentinel-node micrometastases (IBCSG 23-01): 10-year follow-up of a randomized, controlled phase 3 trial. Lancet Oncol 2018;19:1385-1393. https:\/\/doi.org\/10.1016\/S1470-2045(18)30380-2","DOI":"10.1016\/S1470-2045(18)30380-2"},{"key":"10.14639\/0392-100X-A878_ref12","doi-asserted-by":"crossref","unstructured":"Khafif A, Schneebaum S, Fliss DM, et al. Lymphoscintigraphy for sentinel node mapping using a hybrid single photon emission CT (SPECT)\/CT system in oral cavity squamous cell carcinoma. Head Neck 2006;28:874-879. https:\/\/doi.org\/10.1002\/hed.20434","DOI":"10.1002\/hed.20434"},{"key":"10.14639\/0392-100X-A878_ref13","doi-asserted-by":"crossref","unstructured":"Honda K, Ishiyama K, Suzuki S, et al. Sentinel lymph node biopsy using preoperative computed tomographic lymphography and intraoperative indocyanine green fluorescence imaging in patients with localized tongue cancer. JAMA Otolaryngol Head Neck Surg 2019;145:735-740. https:\/\/doi.org\/10.1001\/jamaoto.2019.1243","DOI":"10.1001\/jamaoto.2019.1243"},{"key":"10.14639\/0392-100X-A878_ref14","doi-asserted-by":"crossref","unstructured":"De Cicco C, Trifir\u00f2 G, Calabrese L, et al. Lymphatic mapping to tailor selective lymphadenectomy in cN0 tongue carcinoma: beyond the sentinel node concept. Eur J Nucl Med Mol Imaging 2006;33:900-905. https:\/\/doi.org\/10.1007\/s00259-006-0088-4","DOI":"10.1007\/s00259-006-0088-4"},{"key":"10.14639\/0392-100X-A878_ref15","doi-asserted-by":"crossref","unstructured":"Bredell MG. Sentinel lymph node mapping by indocyanin green fluorescence imaging in oropharyngeal cancer \u2013 Preliminary experience. Head Neck Oncol 2010;2:31. https:\/\/doi.org\/10.1186\/1758-3284-2-31","DOI":"10.1186\/1758-3284-2-31"},{"key":"10.14639\/0392-100X-A878_ref16","doi-asserted-by":"crossref","unstructured":"Ishiguro K, Iwai T, Izumi T, et al. Sentinel lymph node biopsy with preoperative CT lymphography and intraoperative indocyanine green fluorescence imaging for N0 early tongue cancer: a long-term follow-up study. J Craniomaxillofac Surg 2020;48:217-222. https:\/\/doi.org\/10.1016\/j.jcms.2020.01.007","DOI":"10.1016\/j.jcms.2020.01.007"},{"key":"10.14639\/0392-100X-A878_ref17","doi-asserted-by":"crossref","unstructured":"Papathemelis T, Jablonski E, Scharl A, et al. Sentinel lymph node biopsy in breast cancer patients by means of indocyanine green using the Karl Storz VITOM\u00ae Fluorescence Camera. Biomed Res Int 2018:6251468.","DOI":"10.1155\/2018\/6251468"},{"key":"10.14639\/0392-100X-A878_ref18","doi-asserted-by":"crossref","unstructured":"Alkureishi LW, Burak Z, Alvarez JA, et al. European Association of Nuclear Medicine Oncology Committee; European Sentinel Node Biopsy Trial Committee. Joint practice guidelines for radionuclide lymphoscintigraphy for sentinel node localization in oral\/oropharyngeal squamous cell carcinoma. Eur J Nucl Med Mol Imaging 2009;36:1915-1936. https:\/\/doi.org\/10.1007\/s00259-009-1248-0","DOI":"10.1007\/s00259-009-1248-0"},{"key":"10.14639\/0392-100X-A878_ref19","doi-asserted-by":"crossref","unstructured":"Britten AJ. A method to evaluate intra-operative gamma probes for sentinel lymph node localisation. Eur J Nucl Med 2019;26:76-83. https:\/\/doi.org\/10.1007\/s002590050362","DOI":"10.1007\/s002590050362"},{"key":"10.14639\/0392-100X-A878_ref20","doi-asserted-by":"crossref","unstructured":"De Bree R, de Keizer B, Civantos FJ, et al. What is the role of sentinel lymph node biopsy in the management of oral cancer in 2020? Eur Arch Otorhinolaryngol 2021;278:3181-3191. https:\/\/doi.org\/10.1007\/s00405-020-06538-y","DOI":"10.1007\/s00405-020-06538-y"},{"key":"10.14639\/0392-100X-A878_ref21","doi-asserted-by":"crossref","unstructured":"Gurney BA, Schilling C, Putcha V, et al. Implications of a positive sentinel node in oral squamous cell carcinoma. Head Neck 2012;34:1580-1585. https:\/\/doi.org\/10.1002\/hed.21973","DOI":"10.1002\/hed.21973"},{"key":"10.14639\/0392-100X-A878_ref22","doi-asserted-by":"crossref","unstructured":"Mahieu R, den Toom IJ, Boeve K, et al. Contralateral regional recurrence in lateralized or paramedian early-stage oral cancer undergoing sentinel lymph node biopsy \u2013 Comparison to a historic elective neck dissection cohort. Front Oncol 2021;11:644306. https:\/\/doi.org\/10.3389\/fonc.2021.644306","DOI":"10.3389\/fonc.2021.644306"},{"key":"10.14639\/0392-100X-A878_ref23","doi-asserted-by":"crossref","unstructured":"Civantos FJ, Zitsch RP, Schuller DE, et al. Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1-T2 oral squamous cell carcinomas: results of a prospective multiinstitutional trial. J Clin Oncol 2010;28:1395-1400. https:\/\/doi.org\/10.1200\/JCO.2008.20.8777","DOI":"10.1200\/JCO.2008.20.8777"},{"key":"10.14639\/0392-100X-A878_ref24","doi-asserted-by":"crossref","unstructured":"Liu M, Wang SJ, Yang X, et al. Diagnostic efficacy of sentinel lymph node biopsy in early oral squamous cell carcinoma: a meta-analysis of 66 studies. PLoS One 2017;12:E0170322. https:\/\/doi.org\/10.1371\/journal.pone.0170322","DOI":"10.1371\/journal.pone.0170322"},{"key":"10.14639\/0392-100X-A878_ref25","doi-asserted-by":"crossref","unstructured":"Garrel R, Poissonnet G, Moy\u00e0 Plana A. Equivalence randomized trial to compare treatment on the basis of sentinel node biopsy versus neck node dissection in operable T1-T2N0 oral and oropharyngeal cancer. J Clin Oncol 2020;38:34,4010-4018. https:\/\/doi.org\/10.1200\/JCO.20.01661","DOI":"10.1200\/JCO.20.01661"}],"container-title":["Acta Otorhinolaryngologica Italica"],"original-title":[],"link":[{"URL":"https:\/\/www.actaitalica.it\/article\/view\/878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:35:32Z","timestamp":1773646532000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actaitalica.it\/article\/view\/878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,2]]}},"URL":"https:\/\/doi.org\/10.14639\/0392-100x-a878","relation":{},"ISSN":["1827-675X"],"issn-type":[{"value":"1827-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"article-number":"3"}}