{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:22:50Z","timestamp":1782156170264,"version":"3.54.5"},"reference-count":25,"publisher":"Pacini Editore","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Otorhinolaryngol Ital"],"DOI":"10.14639\/0392-100x-n0790","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T06:54:40Z","timestamp":1607496880000},"page":"332-337","source":"Crossref","is-referenced-by-count":13,"title":["New laboratory predictive tools in deep neck space infections","Nuovi indicatori biochimici predittivi di infezioni suppurative cervicali"],"prefix":"10.14639","volume":"40","author":[{"given":"Maria Luisa","family":"Fiorella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi Maria","family":"Madami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orazio Valerio","family":"Giannico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Pontillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Quaranta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20340","published-online":{"date-parts":[[2020,10]]},"reference":[{"key":"10.14639\/0392-100X-N0790_ref1","doi-asserted-by":"crossref","unstructured":"Huang TT, Liu TC, Chen PR, et al. Deep neck infection: analysis of 185 cases. Head Neck 2004;26:854-60. https:\/\/doi.org\/10.1002\/hed.20014","DOI":"10.1002\/hed.20014"},{"key":"10.14639\/0392-100X-N0790_ref2","doi-asserted-by":"crossref","unstructured":"Lin HT, Tsai CS, Chen YL, et al. Influence of diabetes mellitus on deep neck infection. J Laryngol Otol 2006;120:650-4. https:\/\/doi.org\/10.1017\/S0022215106001149","DOI":"10.1017\/S0022215106001149"},{"key":"10.14639\/0392-100X-N0790_ref3","doi-asserted-by":"crossref","unstructured":"Ko\u00e7 A, Alakhras WM, Acipayam H, et al. Seven years of experience in 160 patients with deep neck infection. KBB Uygulamalari 2016;4:22-6. https:\/\/doi.org\/10.5604\/01.3001.0010.5315","DOI":"10.5604\/01.3001.0010.5315"},{"key":"10.14639\/0392-100X-N0790_ref4","doi-asserted-by":"crossref","unstructured":"Huang TT, Liu TC, Chen PR, et al. Deep neck infection: analysis of 185 cases. Head Neck 2004;26:854-60. https:\/\/doi.org\/10.1002\/hed.20014","DOI":"10.1002\/hed.20014"},{"key":"10.14639\/0392-100X-N0790_ref5","doi-asserted-by":"crossref","unstructured":"Velhonoja J, L\u00e4\u00e4veri M, Soukka T, et al. Deep neck space infections: an upward trend and changing characteristics. Eur Arch Otorhinolaryngol 2020;277:863-72. https:\/\/doi.org\/10.1007\/s00405-019-05742-9.","DOI":"10.1007\/s00405-019-05742-9"},{"key":"10.14639\/0392-100X-N0790_ref6","doi-asserted-by":"crossref","unstructured":"Atishkumar B, Vijayalaxmi A, Pallavi K. Deep neck space infection \u2013 a retrospective study of 270 cases at tertiary care center. World J Otorhinolaryngol Head Neck Surg 2016;2:208-13. https:\/\/doi.org\/10.1016\/j.wjorl.2016.11.003","DOI":"10.1016\/j.wjorl.2016.11.003"},{"key":"10.14639\/0392-100X-N0790_ref7","doi-asserted-by":"crossref","unstructured":"Karkas A, Chahine K, Schmerber S, et al. Optimal treatment of cervical necrotizing fasciitis associated with descending necrotizing mediastinitis. British J Surg 2010;97:609-15. https:\/\/doi.org\/10.1002\/bjs.6935","DOI":"10.1002\/bjs.6935"},{"key":"10.14639\/0392-100X-N0790_ref8","doi-asserted-by":"crossref","unstructured":"Muhammad JK, Almadani H, Al Hashemi BA, et al. The value of early intervention and a multidisciplinary approach in the management of necrotizing fasciitis of the neck and anterior mediastinum of odontogenic origin. J Oral Maxillofac Surg 2015;73:918-27. https:\/\/doi.org\/10.1016\/j.joms.2014.12.021","DOI":"10.1016\/j.joms.2014.12.021"},{"key":"10.14639\/0392-100X-N0790_ref9","doi-asserted-by":"crossref","unstructured":"Sethi DS, Stanley RE. Deep neck abscesses - changing trends. J Laryngol Otol 1994;108:138-43. https:\/\/doi.org\/10.1017\/S0022215100126106","DOI":"10.1017\/S0022215100126106"},{"key":"10.14639\/0392-100X-N0790_ref10","doi-asserted-by":"crossref","unstructured":"Fomete B, Agbara R, Osunde DO, et al. Cervicofacial infection in a Nigerian tertiary health institution a retrospective analysis of 77 cases. J Korean Assoc Oral Maxillofac Surg 2015;41:293-8. https:\/\/doi.org\/10.5125\/jkaoms.2015.41.6.293","DOI":"10.5125\/jkaoms.2015.41.6.293"},{"key":"10.14639\/0392-100X-N0790_ref11","doi-asserted-by":"crossref","unstructured":"Goldstein EJC, Anaya DA, Dellinger EP. Necrotizing soft-tissue infection: diagnosis and management. Clin Infect Dis 2007;44:705-10. https:\/\/doi.org\/10.1086\/511638","DOI":"10.1086\/511638"},{"key":"10.14639\/0392-100X-N0790_ref12","doi-asserted-by":"crossref","unstructured":"Wong CH, Khin LW, Heng KS, et al. The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: A tool for distinguishing necrotizing fasciitis from other soft tissue infections. Crit Care Med 2004;32:1535-41. https:\/\/doi.org\/10.1097\/01.ccm.0000129486.35458.7d","DOI":"10.1097\/01.CCM.0000129486.35458.7D"},{"key":"10.14639\/0392-100X-N0790_ref13","doi-asserted-by":"crossref","unstructured":"Kaushik R, Gupta M, Sharma M, et al. Diagnostic and prognostic role of neutrophil-to-lymphocyte ratio in early and late phase of sepsis. Indian J Crit Care Med 2018;22:660-3. https:\/\/doi.org\/10.4103\/ijccm.IJCCM_59_18.","DOI":"10.4103\/ijccm.IJCCM_59_18"},{"key":"10.14639\/0392-100X-N0790_ref14","doi-asserted-by":"crossref","unstructured":"Singer M, Deutschman CS, Seymour CW, et al. The Sepsis Definitions Task Force Members. The third international consensus definition for sepsis and septic shock (Sepsis-3). JAMA 2016;315:801-10. https:\/\/doi.org\/10.1001\/jama.2016.0287","DOI":"10.1001\/jama.2016.0287"},{"key":"10.14639\/0392-100X-N0790_ref15","doi-asserted-by":"crossref","unstructured":"Thomas AJ, Meyer TK. Retrospective evaluation of laboratory-based diagnostic tools for cervical necrotizing fasciitis. Laryngoscope 2012;122:2683-7. https:\/\/doi.org\/10.1002\/lary.23680","DOI":"10.1002\/lary.23680"},{"key":"10.14639\/0392-100X-N0790_ref16","doi-asserted-by":"crossref","unstructured":"Qu L, Liang X, Jiang B, et al. Risk factors affecting the prognosis of descending necrotizing mediastinitis from odontogenic infection. J Oral Maxillofac Surg 2018;76:1207-15. https:\/\/doi.org\/10.1016\/j.joms.2017.12.007","DOI":"10.1016\/j.joms.2017.12.007"},{"key":"10.14639\/0392-100X-N0790_ref17","doi-asserted-by":"crossref","unstructured":"Sarna T, Sengupta T, Miloro M, et al. Cervical nectrotizing fascitis with descending mediastinitis: literature review and case report. J Oral Maxillofac Surg 2012;70:1342-50. https:\/\/doi.org\/10.1016\/j.joms.2011.05.007","DOI":"10.1016\/j.joms.2011.05.007"},{"key":"10.14639\/0392-100X-N0790_ref18","doi-asserted-by":"crossref","unstructured":"Cruz Toro P, Callejo Castillo A, Tornero Salt\u00f3 J, et al. Cervical necrotizing fasciitis: Report of 6 cases and review of literature. Eur Ann Otorhinolaryngol Head Neck Dis 2014;131:357-9. https:\/\/doi.org\/10.1016\/j.anorl.2013.08.006","DOI":"10.1016\/j.anorl.2013.08.006"},{"key":"10.14639\/0392-100X-N0790_ref19","unstructured":"Sandner A, Moritz S, Unverzagt S, et al. Cervical necrotizing fasciitis - the value of the laboratory risk indicator for necrotizing fasciitis score as an indicative parameter. J Oral Maxillofac Surg 2015;73:2319-33. https:\/\/doi.org\/10.1016\/j.jams.2015.05.035"},{"key":"10.14639\/0392-100X-N0790_ref20","doi-asserted-by":"crossref","unstructured":"Dogan M, Akyel A, Bilgin M, et al. Can admission neutrophil to lymphocyte ratio predict infarct-related artery patency in ST-segment elevation myocardial infarction. Clin Appl Thromb Hemost 2015;2:172-6. https:\/\/doi.org\/10.1177\/1076029613515071","DOI":"10.1177\/1076029613515071"},{"key":"10.14639\/0392-100X-N0790_ref21","doi-asserted-by":"crossref","unstructured":"Sen BB, Rifaioglu EN, Ekiz O, et al. Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis. Cutan Ocul Toxicol 2014;33:223-7. https:\/\/doi.org\/10.3109\/15569527.2013.834498","DOI":"10.3109\/15569527.2013.834498"},{"key":"10.14639\/0392-100X-N0790_ref22","doi-asserted-by":"crossref","unstructured":"Farah R, Khamisy-Farah R, et al. Association of neutrophil to lymphocyte ratio with presence and severity of gastritis due to Helicobacter pylori infection. J Clin Lab Anal 2014;28:219-23. https:\/\/doi.org\/10.1002\/jcla.21669","DOI":"10.1002\/jcla.21669"},{"key":"10.14639\/0392-100X-N0790_ref23","doi-asserted-by":"crossref","unstructured":"Ishizuka M, Shimizu T, Kubota K. Neutrophil-to-lymphocyte ratio has a close association with gangrenous appendicitis in patients undergoing appendectomy. Int J Surg 2012;97:299-304. https:\/\/doi.org\/10.9738\/CC161.1","DOI":"10.9738\/CC161.1"},{"key":"10.14639\/0392-100X-N0790_ref24","doi-asserted-by":"crossref","unstructured":"Baglam T, Binnetoglu A, Yumusakhuylu AC, et al. Predictive value of the neutrophil-to-lymphocyte ratio in patients with deep neck space infection secondary to acute bacterial tonsillitis. Int J Ped Otorhinolaryngol 2015;79:1421-4. https:\/\/doi.org\/10.1016\/j.ijporl.2015.06.016","DOI":"10.1016\/j.ijporl.2015.06.016"},{"key":"10.14639\/0392-100X-N0790_ref25","doi-asserted-by":"crossref","unstructured":"Neeki MM, Dong F, Au C. Evaluating the laboratory risk indicator to differentiate cellulitis from necrotizing fasciitis in the emergency department. West J Em Med 2017;18: 684-9. https:\/\/doi.org\/10.5811\/westjem.2017.3.33607","DOI":"10.5811\/westjem.2017.3.33607"}],"container-title":["Acta Otorhinolaryngologica Italica"],"original-title":[],"link":[{"URL":"https:\/\/www.actaitalica.it\/article\/view\/790","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T07:17:09Z","timestamp":1729667829000},"score":1,"resource":{"primary":{"URL":"https:\/\/old.actaitalica.it\/article\/view\/790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,10]]}},"URL":"https:\/\/doi.org\/10.14639\/0392-100x-n0790","relation":{},"ISSN":["1827-675X"],"issn-type":[{"value":"1827-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]},"article-number":"3"}}