{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:12:59Z","timestamp":1753884779675,"version":"3.41.2"},"reference-count":45,"publisher":"Pacini Editore","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Otorhinolaryngol Ital"],"DOI":"10.14639\/0392-100x-n0915","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T06:29:00Z","timestamp":1616394540000},"page":"59-68","source":"Crossref","is-referenced-by-count":6,"title":["Endoscopic surgical treatment of epistaxis in hereditary haemorrhagic telangiectasia: our experience","Il trattamento endoscopico dell\u2019epistassi nella teleangectasia emorragica ereditaria: la nostra esperienza"],"prefix":"10.14639","volume":"41","author":[{"given":"Fabio","family":"Pagella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pusateri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Maiorano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Spinozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Ugolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Lizzio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosolino","family":"Mirabella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmine","family":"Tinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Olivieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Matti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20340","published-online":{"date-parts":[[2021,2]]},"reference":[{"key":"10.14639\/0392-100X-N0915_ref1","doi-asserted-by":"crossref","unstructured":"Faughnan ME, Palda VA, Garcia-Tsao G, et al. International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia. J Med Genet 2011;48:73-87. https:\/\/doi.org\/10.1136\/jmg.2009.069013","DOI":"10.1136\/jmg.2009.069013"},{"key":"10.14639\/0392-100X-N0915_ref2","doi-asserted-by":"crossref","unstructured":"Olivieri C, Pagella F, Semino L, et al. Analysis of ENG and ACVRL1 genes in 137 HHT Italian families identifies 76 different mutations (24 novel). Comparison with other European studies. J Hum Genet 2007;52:820-9. https:\/\/doi.org\/10.1007\/s10038-007-0187-5","DOI":"10.1007\/s10038-007-0187-5"},{"key":"10.14639\/0392-100X-N0915_ref3","doi-asserted-by":"crossref","unstructured":"Pagella F, Pusateri A, Chu F, et al. Narrow-band imaging in the endoscopic evaluation of hereditary hemorrhagic telangiectasia patients. Laryngoscope 2013;123:2967-8. https:\/\/doi.org\/10.1002\/lary.24338","DOI":"10.1002\/lary.24338"},{"key":"10.14639\/0392-100X-N0915_ref4","doi-asserted-by":"crossref","unstructured":"Pagella F, Pusateri A, Zaccari D, et al. Fluorescein-guided intraoperative endoscopy in patients with hereditary hemorrhagic telangiectasia: first impressions. Int Forum Allergy Rhinol 2017;7:300-3. https:\/\/doi.org\/10.1002\/alr.21880","DOI":"10.1002\/alr.21880"},{"key":"10.14639\/0392-100X-N0915_ref5","doi-asserted-by":"crossref","unstructured":"Invernizzi R, Quaglia F, Klersy C, et al. Efficacy and safety of thalidomide for the treatment of severe recurrent epistaxis in hereditary haemorrhagic telangiectasia: results of a non-randomised, single-centre, phase 2 study. Lancet Haematol 2015;2:e465-e73. https:\/\/doi.org\/10.1016\/S2352-3026(15)00195-7","DOI":"10.1016\/S2352-3026(15)00195-7"},{"key":"10.14639\/0392-100X-N0915_ref6","doi-asserted-by":"crossref","unstructured":"Pagella F, Colombo A, Matti E, et al. Correlation of severity of epistaxis with nasal telangiectasias in hereditary hemorrhagic telangiectasia (HHT) patients. Am J Rhinol Allergy 2009;23:52-8. https:\/\/doi.org\/10.2500\/ajra.2009.23.3263","DOI":"10.2500\/ajra.2009.23.3263"},{"key":"10.14639\/0392-100X-N0915_ref7","doi-asserted-by":"crossref","unstructured":"Silva BM, Hosman AE, Devlin HL, et al. Lifestyle and dietary influences on nosebleed severity in hereditary hemorrhagic telangiectasia. Laryngoscope 2013;123:1092-9. https:\/\/doi.org\/10.1002\/lary.23893","DOI":"10.1002\/lary.23893"},{"key":"10.14639\/0392-100X-N0915_ref8","doi-asserted-by":"crossref","unstructured":"Gaillard S, Dupuis-Girod S, Boutitie F, et al. Tranexamic acid for epistaxis in hereditary hemorrhagic telangiectasia patients: a European cross-over controlled trial in a rare disease. J Thromb Haemost 2014;12:1494-502. https:\/\/doi.org\/10.1111\/jth.12654","DOI":"10.1111\/jth.12654"},{"key":"10.14639\/0392-100X-N0915_ref9","doi-asserted-by":"crossref","unstructured":"Dupuis-Girod S, Ambrun A, Decullier E, et al. ELLIPSE Study: a Phase 1 study evaluating the tolerance of bevacizumab nasal spray in the treatment of epistaxis in hereditary hemorrhagic telangiectasia. mAbs 2014;6:793-8. https:\/\/doi.org\/10.4161\/mabs.28025","DOI":"10.4161\/mabs.28025"},{"key":"10.14639\/0392-100X-N0915_ref10","doi-asserted-by":"crossref","unstructured":"Sautter NB, Smith TL. Treatment of hereditary hemorrhagic telangiectasia-related epistaxis. Otolaryngol Clin North Am 2016;49:639-54. https:\/\/doi.org\/10.1016\/j.otc.2016.02.010","DOI":"10.1016\/j.otc.2016.02.010"},{"key":"10.14639\/0392-100X-N0915_ref11","doi-asserted-by":"crossref","unstructured":"Faughnan ME, Mager JJ, Hetts SW, et al. Second International Guidelines for the diagnosis and management of hereditary hemorrhagic telangiectasia. Ann Intern Med 2020;173:989-1001. https:\/\/doi.org\/10.7326\/M20-1443","DOI":"10.7326\/M20-1443"},{"key":"10.14639\/0392-100X-N0915_ref12","doi-asserted-by":"crossref","unstructured":"Lund VJ, Darby Y, Rimmer J, et al. Nasal closure for severe hereditary haemorrhagic telangiectasia in 100 patients. The Lund modification of the Young\u2019s procedure: a 22-year experience. Rhinology 2017;55:135-41. https:\/\/doi.org\/10.4193\/Rhin16.315","DOI":"10.4193\/Rhin16.315"},{"key":"10.14639\/0392-100X-N0915_ref13","doi-asserted-by":"crossref","unstructured":"Hosni AA, Innes AJ. Hereditary haemorrhagic telangiectasia: Young\u2019s procedure in the management of epistaxis. J Laryngol Otol 1994;108:754-7. https:\/\/doi.org\/10.1017\/s0022215100128026","DOI":"10.1017\/S0022215100128026"},{"key":"10.14639\/0392-100X-N0915_ref14","doi-asserted-by":"crossref","unstructured":"Pagella F, Semino L, Olivieri C, et al. Treatment of epistaxis in hereditary hemorrhagic telangiectasia patients by argon plasma coagulation with local anesthesia. Am J Rhinol 2006;20:421-5. https:\/\/doi.org\/10.2500\/ajr.2006.20.2886","DOI":"10.2500\/ajr.2006.20.2886"},{"key":"10.14639\/0392-100X-N0915_ref15","doi-asserted-by":"crossref","unstructured":"Lesnik GT, Ross DA, Henderson KJ, et al. Septectomy and septal dermoplasty for the treatment of severe transfusion-dependent epistaxis in patients with hereditary hemorrhagic telangiectasia and septal perforation. Am J Rhinol 2007;21:312-5. https:\/\/doi.org\/10.2500\/ajr.2007.21.3017","DOI":"10.2500\/ajr.2007.21.3017"},{"key":"10.14639\/0392-100X-N0915_ref16","doi-asserted-by":"crossref","unstructured":"Pagella F, Matti E, Chu F, et al. Argon plasma coagulation is an effective treatment for hereditary hemorrhagic telangiectasia patients with severe nosebleeds. Acta Otolaryngol 2013;133:174-80. https:\/\/doi.org\/10.3109\/00016489.2012.718097","DOI":"10.3109\/00016489.2012.718097"},{"key":"10.14639\/0392-100X-N0915_ref17","doi-asserted-by":"crossref","unstructured":"Bergler W, Riedel F, Baker-Schreyer A, et al. Argon plasma coagulation for the treatment of hereditary hemorrhagic telangiectasia. Laryngoscope 1999;109:15-20. https:\/\/doi.org\/10.1097\/00005537-199901000-00004","DOI":"10.1097\/00005537-199901000-00004"},{"key":"10.14639\/0392-100X-N0915_ref18","unstructured":"Fiorella ML, Lillo L, Fiorella R. Diode laser in the treatment of epistaxis in patients with hereditary haemorrhagic telangiectasia. Acta Otorhinolaryngol Ital 2012;32:164-9."},{"key":"10.14639\/0392-100X-N0915_ref19","doi-asserted-by":"crossref","unstructured":"Chin CJ, Rotenberg BW, Witterick IJ. Epistaxis in hereditary hemorrhagic telangiectasia: an evidence based review of surgical management. J Otolaryngol Head Neck Surg 2016;45:3. https:\/\/doi.org\/10.1186\/s40463-016-0116-8.","DOI":"10.1186\/s40463-016-0116-8"},{"key":"10.14639\/0392-100X-N0915_ref20","doi-asserted-by":"crossref","unstructured":"Boyer H, Fernandes P, Duran O, et al. Office-based sclerotherapy for recurrent epistaxis due to hereditary hemorrhagic telangiectasia: a pilot study. Int Forum Allergy Rhinol 2011;1:319-23. https:\/\/doi.org\/10.1002\/alr.20053","DOI":"10.1002\/alr.20053"},{"key":"10.14639\/0392-100X-N0915_ref21","doi-asserted-by":"crossref","unstructured":"Morais D, Mill\u00e1s T, Zarrabeitia R, et al. Local sclerotherapy with polydocanol (Aethoxysklerol\u00ae) for the treatment of epistaxis in rendu-osler-weber or hereditary hemorrhagic telangiectasia (HHT): 15 years of experience. Rhinology 2012;50:80-6. https:\/\/doi.org\/10.4193\/Rhino11.211","DOI":"10.4193\/Rhino11.211"},{"key":"10.14639\/0392-100X-N0915_ref22","doi-asserted-by":"crossref","unstructured":"Boyer H, Fernandes P, Le C, et al. Prospective randomized trial of sclerotherapy vs standard treatment for epistaxis due to hereditary hemorrhagic telangiectasia. Int Forum Allergy Rhinol 2015;5:435-40. https:\/\/doi.org\/10.1002\/alr.21484","DOI":"10.1002\/alr.21484"},{"key":"10.14639\/0392-100X-N0915_ref23","doi-asserted-by":"crossref","unstructured":"Esteban-Casado S, Mart\u00edn de Rosales Cabrera AM, Usarralde P\u00e9rez A, et al. Sclerotherapy and topical nasal propranolol: an effective and safe therapy for HHT-epistaxis. Laryngoscope 2019;129:221623. https:\/\/doi.org\/10.1002\/lary.27930","DOI":"10.1002\/lary.27930"},{"key":"10.14639\/0392-100X-N0915_ref24","unstructured":"Hanks JE, Hunter D, Goding GS Jr, et al. Complications from office sclerotherapy for epistaxis due to hereditary hemorrhagic telangiectasia (HHT or Osler-Weber-Rendu). Int Forum Allergy Rhinol 2014;4:422-7. https:\/\/doi.org\/10.1002\/alr.2128"},{"key":"10.14639\/0392-100X-N0915_ref25","doi-asserted-by":"crossref","unstructured":"Ghaheri BA, Fong KJ, Hwang PH. The utility of bipolar electrocautery in hereditary hemorrhagic telangiectasia. Otolaryngol Head Neck Surg 2006;134:1006-9. https:\/\/doi.org\/10.1016\/j.otohns.2005.12.019","DOI":"10.1016\/j.otohns.2005.12.019"},{"key":"10.14639\/0392-100X-N0915_ref26","doi-asserted-by":"crossref","unstructured":"Abiri A, Goshtasbi K, Maducdoc M, et al. Laser-assisted control of epistaxis in hereditary hemorrhagic telangiectasia: a systematic review. Lasers Surg Med 2020;52:293-300. https:\/\/doi.org\/10.1002\/lsm.23147","DOI":"10.1002\/lsm.23147"},{"key":"10.14639\/0392-100X-N0915_ref27","doi-asserted-by":"crossref","unstructured":"Luk L, Mace JC, Bhandarkar ND, et al. Comparison of electrosurgical plasma coagulation and potassium-titanyl-phosphate laser photocoagulation for treatment of hereditary hemorrhagic telangiectasia-related epistaxis. Int Forum Allergy Rhinol 2014;4:640-5. https:\/\/doi.org\/10.1002\/alr.21328","DOI":"10.1002\/alr.21328"},{"key":"10.14639\/0392-100X-N0915_ref28","doi-asserted-by":"crossref","unstructured":"J\u00f8rgensen G, Lange B, Wanscher JH, et al. Efficiency of laser treatment in patients with hereditary hemorrhagic telangiectasia. Eur Arch Otorhinolaryngol 2011;268:1765-70. https:\/\/doi.org\/10.1007\/s00405-011-1677-9","DOI":"10.1007\/s00405-011-1677-9"},{"key":"10.14639\/0392-100X-N0915_ref29","doi-asserted-by":"crossref","unstructured":"Papaspyrou G, Schick B, Al Kadah B. Nd:YAG laser treatment for extranasal telangiectasias: a retrospective analysis of 38 patients with hereditary hemorrhagic telangiectasia and review of the literature. ORL J Otorhinolaryngol Relat Spec 2016;78:245-51. https:\/\/doi.org\/10.1159\/000447949","DOI":"10.1159\/000447949"},{"key":"10.14639\/0392-100X-N0915_ref30","doi-asserted-by":"crossref","unstructured":"Papaspyrou G, Hecker D, Linxweiler M, et al. Combined therapy for epistaxis by hereditary hemorrhagic teleangiectasia: a 3-year follow up study on 45 patients. J Craniomaxillofac Surg 2017;45:1179-82. https:\/\/doi.org\/10.1016\/j.jcms.2017.05.018","DOI":"10.1016\/j.jcms.2017.05.018"},{"key":"10.14639\/0392-100X-N0915_ref31","doi-asserted-by":"crossref","unstructured":"Kuan EC, Peng KA, Thompson CF, et al. Sinonasal quality of life outcomes following laser treatment of epistaxis related to hereditary hemorrhagic telangiectasia. Lasers Med Sci 2017;32:527-31. https:\/\/doi.org\/10.1007\/s10103-017-2144-7","DOI":"10.1007\/s10103-017-2144-7"},{"key":"10.14639\/0392-100X-N0915_ref32","doi-asserted-by":"crossref","unstructured":"Poje G, Kavanagh MM. Hereditary hemorrhagic telangiectasia-laser treatment of epistaxis. Ear Nose Throat J 2017;96:E10-E4.","DOI":"10.1177\/014556131709600803"},{"key":"10.14639\/0392-100X-N0915_ref33","doi-asserted-by":"crossref","unstructured":"Ishibashi T, Takamatsu S. Hereditary hemorrhagic telangiectasis treated by the harmonic scalpel. Head Neck 2003;25:333-6. https:\/\/doi.org\/10.1002\/hed.10201","DOI":"10.1002\/hed.10201"},{"key":"10.14639\/0392-100X-N0915_ref34","doi-asserted-by":"crossref","unstructured":"Mortuaire G, Boute O, Hatron PY, et al. Pilot study of submucosal radiofrequency for epistaxis in hereditary hemorrhagic telangiectasia. Rhinology 2013;51:355-60. https:\/\/doi.org\/10.4193\/Rhin13.027","DOI":"10.4193\/Rhin13.027"},{"key":"10.14639\/0392-100X-N0915_ref35","doi-asserted-by":"crossref","unstructured":"Rotenberg B, Noyek S, Chin CJ. Radiofrequency ablation for treatment of hereditary hemorrhagic telangiectasia lesions: \u201cHow I do it\u201d. Am J Rhinol Allergy 2015;29:226-7. https:\/\/doi.org\/10.2500\/ajra.2015.29.4163","DOI":"10.2500\/ajra.2015.29.4163"},{"key":"10.14639\/0392-100X-N0915_ref36","doi-asserted-by":"crossref","unstructured":"Joshi H, Woodworth BA, Carney AS. Coblation for epistaxis management in patients with hereditary haemorrhagic telangiectasia: a multicentre case series. J Laryngol Otol 2011;125:1176-80. https:\/\/doi.org\/10.1017\/S0022215111001733","DOI":"10.1017\/S0022215111001733"},{"key":"10.14639\/0392-100X-N0915_ref37","doi-asserted-by":"crossref","unstructured":"Harvey RJ, Kanagalingam J, Lund VJ. The impact of septodermoplasty and potassium-titanyl-phosphate (KTP) laser therapy in the treatment of hereditary hemorrhagic telangiectasia-related epistaxis. Am J Rhinol 2008;22:182-7. https:\/\/doi.org\/10.2500\/ajr.2008.22.3145","DOI":"10.2500\/ajr.2008.22.3145"},{"key":"10.14639\/0392-100X-N0915_ref38","doi-asserted-by":"crossref","unstructured":"Ichimura K, Tanaka H, Yamamoto Y, et al. Nasal dermoplasty for Japanese hereditary hemorrhagic telangiectasia. Auris Nasus Larynx 2006;33:423-8. https:\/\/doi.org\/10.1016\/j.anl.2006.03.001","DOI":"10.1016\/j.anl.2006.03.001"},{"key":"10.14639\/0392-100X-N0915_ref39","doi-asserted-by":"crossref","unstructured":"Levine CG, Ross DA, Henderson KJ, et al. Long-term complications of septal dermoplasty in patients with hereditary hemorrhagic telangiectasia. Otolaryngol Head Neck Surg 2008;138:721-4. https:\/\/doi.org\/10.1016\/j.otohns.2008.01.005","DOI":"10.1016\/j.otohns.2008.01.005"},{"key":"10.14639\/0392-100X-N0915_ref40","doi-asserted-by":"crossref","unstructured":"Rimmer J, Lund VJ. A modified technique for septodermoplasty in hereditary hemorrhagic telangiectasia. Laryngoscope 2014;124:67-9. https:\/\/doi.org\/10.1002\/lary.24303","DOI":"10.1002\/lary.24303"},{"key":"10.14639\/0392-100X-N0915_ref41","doi-asserted-by":"crossref","unstructured":"Ichimura K, Kikuchi H, Imayoshi S, et al. Are patients with severe epistaxis caused by hereditary hemorrhagic telangiectasia satisfied with nostril closure surgery? Auris Nasus Larynx 2012;39:59-64. https:\/\/doi.org\/10.1016\/j.anl.2011.03.003","DOI":"10.1016\/j.anl.2011.03.003"},{"key":"10.14639\/0392-100X-N0915_ref42","doi-asserted-by":"crossref","unstructured":"Richer SL, Geisthoff UW, Livada N, et al. The Young\u2019s procedure for severe epistaxis from hereditary hemorrhagic telangiectasia. Am J Rhinol Allergy 2012;26:401-4. https:\/\/doi.org\/10.2500\/ajra.2012.26.3809","DOI":"10.2500\/ajra.2012.26.3809"},{"key":"10.14639\/0392-100X-N0915_ref43","doi-asserted-by":"crossref","unstructured":"Andersen JH, Kjeldsen AD. Patient-recorded benefit from nasal closure in a Danish cohort of patients with hereditary haemorrhagic telangiectasia. Eur Arch Otorhinolaryngol 2020;277:791-800. https:\/\/doi.org\/10.1007\/s00405-019-05758-1","DOI":"10.1007\/s00405-019-05758-1"},{"key":"10.14639\/0392-100X-N0915_ref44","doi-asserted-by":"crossref","unstructured":"Lee JM, Wu V, Faughnan ME, et al. Prospective pilot study of Floseal\u00ae for the treatment of anterior epistaxis in patients with hereditary hemorrhagic telangiectasia (HHT). J Otolaryngol Head Neck Surg 2019;48:48. https:\/\/doi.org\/10.1186\/s40463-019-0379-y","DOI":"10.1186\/s40463-019-0379-y"},{"key":"10.14639\/0392-100X-N0915_ref45","doi-asserted-by":"crossref","unstructured":"Meccariello G, Georgalas C, Montevecchi F, et al. Management of idiopathic epistaxis in adults: what\u2019s new? Acta Otorhinolaryngol Ital 2019;39:211-9. https:\/\/doi.org\/10.14639\/0392-100X-2155","DOI":"10.14639\/0392-100X-2155"}],"container-title":["Acta Otorhinolaryngologica Italica"],"original-title":[],"link":[{"URL":"https:\/\/www.actaitalica.it\/article\/view\/915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T07:17:32Z","timestamp":1729667852000},"score":1,"resource":{"primary":{"URL":"https:\/\/old.actaitalica.it\/article\/view\/915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,2]]}},"URL":"https:\/\/doi.org\/10.14639\/0392-100x-n0915","relation":{},"ISSN":["1827-675X"],"issn-type":[{"type":"electronic","value":"1827-675X"}],"subject":[],"published":{"date-parts":[[2021,2]]},"article-number":"9"}}