{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:30:29Z","timestamp":1784039429170,"version":"3.55.0"},"reference-count":20,"publisher":"Pacini Editore","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Otorhinolaryngol Ital"],"DOI":"10.14639\/0392-100x-n0996","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T12:45:18Z","timestamp":1612874718000},"page":"457-462","source":"Crossref","is-referenced-by-count":5,"title":["The effect of N-acetyl cysteine on biofilm layers in an experimental model of chronic otitis media","L\u2019effetto della N-acetil cisteina sullo strato di biofilm in un modello sperimentale di otite media cronica"],"prefix":"10.14639","volume":"40","author":[{"given":"Elif","family":"Ersoy \u00c7all\u0131o\u011flu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Ber\u00e7in","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl\u00e7in","family":"Ba\u015fdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzaffer","family":"Kiri\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lkan","family":"Tatar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"Tuzuner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolga","family":"O\u011fuzhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba","family":"M\u00fcderris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Fevzi","family":"Sargon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Hakan","family":"Korkmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20340","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"10.14639\/0392-100X-N0996_ref1","doi-asserted-by":"crossref","unstructured":"Leone S, Molinaro A, Alfieri F, et al. The biofilm matrix of Pseudomonas sp. OX1 grown on phenol is mainly constituted by alginate oligosaccharides. Carbohydr Res 2006;341:2456-61. https:\/\/doi.org\/10.1016\/j.carres.2006.06.011","DOI":"10.1016\/j.carres.2006.06.011"},{"key":"10.14639\/0392-100X-N0996_ref2","doi-asserted-by":"crossref","unstructured":"O\u2019Toole GA, Kaplan, HB. Biofilm formation as microbial development. Ann Rev Microbiol 2000;54:49-79. https:\/\/doi.org\/10.1146\/annurev.micro.54.1.49","DOI":"10.1146\/annurev.micro.54.1.49"},{"key":"10.14639\/0392-100X-N0996_ref3","doi-asserted-by":"crossref","unstructured":"Dohar JE, Hebda PA, Veeh R, et al. Mucosal biofilm formation on middle-ear mucosa in a nonhuman primate model of chronic suppurative otitis media. Laryngoscope 2005;115:1469-72. https:\/\/doi.org\/10.1097\/01.mlg.0000172036.82897.d4","DOI":"10.1097\/01.mlg.0000172036.82897.d4"},{"key":"10.14639\/0392-100X-N0996_ref4","doi-asserted-by":"crossref","unstructured":"Dodd S, Dean O, Copolov DL, et al. N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility. Expert Opin Biol Ther 2008;8:1955-62. https:\/\/doi.org\/10.1517\/14728220802517901","DOI":"10.1517\/14728220802517901"},{"key":"10.14639\/0392-100X-N0996_ref5","doi-asserted-by":"crossref","unstructured":"Berk M, Copolov DL, Dean O, et al. N-acetyl cysteine for depressive symptoms in bipolar disorder a double-blind randomized placebo-controlled trial. Biol Psychiatry 2008;64:468-75. https:\/\/doi.org\/ 10.1016\/j.biopsych.2008.04.022","DOI":"10.1016\/j.biopsych.2008.04.022"},{"key":"10.14639\/0392-100X-N0996_ref6","doi-asserted-by":"crossref","unstructured":"Riise GC, Qvarfordt I, Larsson S, et al. Inhibitory effect of N-acetylcysteine on adherence of Streptococcus pneumoniae and Haemophilus influenzae to human oropharyngeal epithelial cells in vitro. Respiration 2000;67:552-8. https:\/\/doi.org\/10.1159\/000067473","DOI":"10.1159\/000067473"},{"key":"10.14639\/0392-100X-N0996_ref7","doi-asserted-by":"crossref","unstructured":"Stey C, Steurer J, Bachmann S, et al. The effect of oral N-acetylcysteine in chronic bronchitis: aquantitative systematic review. Eur Respir J 2000;16:253-62. https:\/\/doi.org\/10.1034\/j.1399-3003.2000.16b12.x","DOI":"10.1034\/j.1399-3003.2000.16b12.x"},{"key":"10.14639\/0392-100X-N0996_ref8","doi-asserted-by":"crossref","unstructured":"Kauffman CA. Quandary about treatment of aspergillomas persists. Lancet 1996;347:1640. https:\/\/doi.org\/10.1016\/s0140-6736(96)91481-6","DOI":"10.1016\/S0140-6736(96)91481-6"},{"key":"10.14639\/0392-100X-N0996_ref9","doi-asserted-by":"crossref","unstructured":"Perez-Giraldo C, Rodriguez-Benito A, Moran FJ, et al. Influence of N-acetylcysteine on the formation of biofilm by Staphylococcus epidermidis. J Antimicrob Chemother 1997;39:643-6. https:\/\/doi.org\/10.1093\/jac\/39.5.643","DOI":"10.1093\/jac\/39.5.643"},{"key":"10.14639\/0392-100X-N0996_ref10","doi-asserted-by":"crossref","unstructured":"Marchese A, Bozzolasco M, Gualco L, et al. Effect of fosfomycin alone and in combination with N-acetylcysteine on E. coli biofilms. Int J Antimicrob Agents 2003;22:95-100. https:\/\/doi.org\/10.1016\/s0924-8579(03)00232-2","DOI":"10.1016\/S0924-8579(03)00232-2"},{"key":"10.14639\/0392-100X-N0996_ref11","doi-asserted-by":"crossref","unstructured":"Schwandt LQ, Van Weissenbruch R, Stokroos I, et al. Prevention of biofilm formation by dairy products and N-acetylcysteine on voice prostheses in an artificial throat. Acta Otolaryngol 2004;124:726-31. https:\/\/doi.org\/10.1080\/00016480410022516","DOI":"10.1080\/00016480410022516"},{"key":"10.14639\/0392-100X-N0996_ref12","doi-asserted-by":"crossref","unstructured":"Zhao T, Liu Y. N-acetylcysteine inhibit biofilms produced by Pseudomonas aeruginosa. BMC Microbiol 2010;10:140. https:\/\/doi.org\/ 10.1186\/1471-2180-10-140","DOI":"10.1186\/1471-2180-10-140"},{"key":"10.14639\/0392-100X-N0996_ref13","doi-asserted-by":"crossref","unstructured":"Dohar JE, Alper CM, Rose EA, et al. Treatment of chronic suppurative otitis media with topical ciprofloxacin. Ann Otol Rhinol Laryngol 1998;107(10 Pt 1):865-71. https:\/\/doi.org\/ 10.1177\/000348949810701010","DOI":"10.1177\/000348949810701010"},{"key":"10.14639\/0392-100X-N0996_ref14","doi-asserted-by":"crossref","unstructured":"Alper CM, Dohar JE, Gulhan M, et al. Treatment of chronic suppurative otitis media with topical tobramycin and dexamethasone. Arch Otolaryngol Head Neck Surg 2000;126:165-73. https:\/\/doi.org\/ 10.1001\/archotol.126.2.165","DOI":"10.1001\/archotol.126.2.165"},{"key":"10.14639\/0392-100X-N0996_ref15","doi-asserted-by":"crossref","unstructured":"Saylam G, Tatar EC, Tatar I, et al. Association of adenoid surface biofilm formation and chronic otitis media with effusion. Arch Otolaryngol Head Neck Surg 2010;136:550-5. https:\/\/doi.org\/10.1001\/archoto.2010.70","DOI":"10.1001\/archoto.2010.70"},{"key":"10.14639\/0392-100X-N0996_ref16","unstructured":"El-Feky MA, El-Rehewy MS, Hassan MA, et al. Effect of ciprofloxacin and N-acetylcysteine on bacterial adherence and biofilm formation on ureteral stent surfaces. Pol J Microbiol 2009;58:261-7."},{"key":"10.14639\/0392-100X-N0996_ref17","doi-asserted-by":"crossref","unstructured":"Onger ME, Gocer H, Emir D, et al. N-acetylcysteine eradicates Pseudomonas aeruginosa biofilms in bone cement. Scanning 2016;38:766-70. https:\/\/doi.org\/10.1002\/sca.21326","DOI":"10.1002\/sca.21326"},{"key":"10.14639\/0392-100X-N0996_ref18","doi-asserted-by":"crossref","unstructured":"Ozcan C, G\u00f6r\u00fcr K, Cinel L, et al. The inhibitory effect of topical N-acetylcysteine application on myringosclerosis in perforated rat tympanic membrane. Int J Pediatr Otorhinolaryngol 2002;63:179-84. https:\/\/doi.org\/10.1016\/s0165-5876(01)00640-1","DOI":"10.1016\/S0165-5876(01)00640-1"},{"key":"10.14639\/0392-100X-N0996_ref19","doi-asserted-by":"crossref","unstructured":"Yamada M, Tsukimura N, Ikeda T, et al. N-acetyl cysteine as an osteogenesis-enhancing molecule for bone regeneration. Biomaterials 2013;34:6147-56. https:\/\/doi.org\/10.1016\/j.biomaterials.2013.04.064","DOI":"10.1016\/j.biomaterials.2013.04.064"},{"key":"10.14639\/0392-100X-N0996_ref20","doi-asserted-by":"crossref","unstructured":"Choe WT, Murray MT, Stidham KR, et al. N-acetylcysteine as an adjunct for refractory ear infections. Otol Neurotol 2007;28:1022-5.","DOI":"10.1097\/MAO.0b013e318155a4d3"}],"container-title":["Acta Otorhinolaryngologica Italica"],"original-title":[],"link":[{"URL":"https:\/\/www.actaitalica.it\/article\/view\/996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T07:17:45Z","timestamp":1729667865000},"score":1,"resource":{"primary":{"URL":"https:\/\/old.actaitalica.it\/article\/view\/996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,12]]}},"URL":"https:\/\/doi.org\/10.14639\/0392-100x-n0996","relation":{},"ISSN":["1827-675X"],"issn-type":[{"value":"1827-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12]]},"article-number":"10"}}