{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:17:36Z","timestamp":1790619456401,"version":"4.1.0"},"reference-count":53,"publisher":"Pacini Editore","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Otorhinolaryngol Ital"],"DOI":"10.14639\/0392-100x-n2955","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T08:04:41Z","timestamp":1742285081000},"page":"10-20","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic value of changes in pre- and postoperative inflammatory blood markers in HPV-negative head and neck squamous cell carcinomas"],"prefix":"10.14639","volume":"45","author":[{"given":"Tommaso","family":"Mazzocco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Migliorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Tirelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Tomasoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Rampinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Piazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Nicolai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Baggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Lupato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Uderzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Trabalzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Mauramati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ciorba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Giudici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Polesel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Borsetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Boscolo-Rizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20340","published-online":{"date-parts":[[2025,1]]},"reference":[{"key":"10.14639\/0392-100X-N2955_ref1","doi-asserted-by":"crossref","unstructured":"Ferlay J, Colombet M, Soerjomataram I, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer 2019;144:1941-1953. https:\/\/doi.org\/10.1002\/ijc.31937","DOI":"10.1002\/ijc.31937"},{"key":"10.14639\/0392-100X-N2955_ref2","doi-asserted-by":"crossref","unstructured":"Du E, Mazul AL, Farquhar D, et al. Long-term survival in head and neck cancer: impact of site, stage, smoking, and human papillomavirus status. Laryngoscope 2019;129:2506-2513. https:\/\/doi.org\/10.1002\/lary.27807","DOI":"10.1002\/lary.27807"},{"key":"10.14639\/0392-100X-N2955_ref3","doi-asserted-by":"crossref","unstructured":"Zhou S, Yuan H, Wang J, et al. Prognostic value of systemic inflammatory marker in patients with head and neck squamous cell carcinoma undergoing surgical resection. Future Oncol 2020;16:559-571. https:\/\/doi.org\/10.2217\/fon-2020-0010","DOI":"10.2217\/fon-2020-0010"},{"key":"10.14639\/0392-100X-N2955_ref4","doi-asserted-by":"crossref","unstructured":"Tham T, Bardash Y, Herman SW, et al. Neutrophil-to-lymphocyte ratio as a prognostic indicator in head and neck cancer: a systematic review and meta-analysis. Head Neck 2018;40:2546-2557. https:\/\/doi.org\/10.1002\/hed.25324","DOI":"10.1002\/hed.25324"},{"key":"10.14639\/0392-100X-N2955_ref5","doi-asserted-by":"crossref","unstructured":"Borsetto D, Tomasoni M, Payne K, et al. Prognostic significance of CD4+ and CD8+ tumor-infiltrating lymphocytes in head and neck squamous cell carcinoma: a meta-analysis. Cancers (Basel) 2021;13:781. https:\/\/doi.org\/10.3390\/cancers13040781","DOI":"10.3390\/cancers13040781"},{"key":"10.14639\/0392-100X-N2955_ref6","doi-asserted-by":"crossref","unstructured":"Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001;357:539-545. https:\/\/doi.org\/10.1016\/S0140-6736(00)04046-0","DOI":"10.1016\/S0140-6736(00)04046-0"},{"key":"10.14639\/0392-100X-N2955_ref7","doi-asserted-by":"crossref","unstructured":"Abelardo E, Davies G, Kamhieh Y, et al. Are inflammatory markers significant prognostic factors for head and neck cancer patients? J Otorhinolaryngol Relat Spec 2020;82:235-244. https:\/\/doi.org\/10.1159\/000507027","DOI":"10.1159\/000507027"},{"key":"10.14639\/0392-100X-N2955_ref8","doi-asserted-by":"crossref","unstructured":"Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-674. https:\/\/doi.org\/10.1016\/j.cell.2011.02.013","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"10.14639\/0392-100X-N2955_ref9","doi-asserted-by":"crossref","unstructured":"Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70. https:\/\/doi.org\/10.1016\/S0092-8674(00)81683-9","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"10.14639\/0392-100X-N2955_ref10","doi-asserted-by":"crossref","unstructured":"Binnewies M, Roberts EW, Kersten K, et al. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat Med 2018;24:541-550. https:\/\/doi.org\/10.1038\/s41591-018-0014-x","DOI":"10.1038\/s41591-018-0014-x"},{"key":"10.14639\/0392-100X-N2955_ref11","doi-asserted-by":"crossref","unstructured":"Song Q, Wu J, Wang S, et al. Perioperative change in neutrophil count predicts worse survival in esophageal squamous cell carcinoma. Future Oncol 2021;17:4721-4731. https:\/\/doi.org\/10.2217\/fon-2021-0371","DOI":"10.2217\/fon-2021-0371"},{"key":"10.14639\/0392-100X-N2955_ref12","doi-asserted-by":"crossref","unstructured":"Takenaka Y, Oya R, Kitamiura T, et al. Prognostic role of neutrophil-to-lymphocyte ratio in head and neck cancer: a meta-analysis. Head Neck 2018;40:647-655. https:\/\/doi.org\/10.1002\/hed.24986","DOI":"10.1002\/hed.24986"},{"key":"10.14639\/0392-100X-N2955_ref13","doi-asserted-by":"crossref","unstructured":"Templeton AJ, McNamara MG, \u0160eruga B, et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst 2014;106:1-11. https:\/\/doi.org\/10.1093\/jnci\/dju124","DOI":"10.1093\/jnci\/dju124"},{"key":"10.14639\/0392-100X-N2955_ref14","doi-asserted-by":"crossref","unstructured":"Kuss I, Hathaway B, Ferris RL, et al. Imbalance in absolute counts of T lymphocyte subsets in patients with head and neck cancer and its relation to disease. Adv Otorhinolaryngol 2005;62:161-172. https:\/\/doi.org\/10.1159\/000082506","DOI":"10.1159\/000082506"},{"key":"10.14639\/0392-100X-N2955_ref15","doi-asserted-by":"crossref","unstructured":"Greenfeld K, Avraham R, Benish M, et al. Immune suppression while awaiting surgery and following it: dissociations between plasma cytokine levels, their induced production, and NK cell cytotoxicity. Brain Behav Immun 2007;21:503-513. https:\/\/doi.org\/10.1016\/j.bbi.2006.12.006","DOI":"10.1016\/j.bbi.2006.12.006"},{"key":"10.14639\/0392-100X-N2955_ref16","doi-asserted-by":"crossref","unstructured":"Dov\u0161ak T, Ihan A, Didanovi\u010d V, et al. Effect of surgery and radiotherapy on complete blood count, lymphocyte subsets and inflammatory response in patients with advanced oral cancer. BMC Cancer 2018;18:235. https:\/\/doi.org\/10.1186\/s12885-018-4136-9","DOI":"10.1186\/s12885-018-4136-9"},{"key":"10.14639\/0392-100X-N2955_ref17","doi-asserted-by":"crossref","unstructured":"Tazzyman S, Lewis CE, Murdoch C. Neutrophils: key mediators of tumour angiogenesis. Int J Exp Pathol 2009;90:222-231. https:\/\/doi.org\/10.1111\/j.1365-2613.2009.00641.x","DOI":"10.1111\/j.1365-2613.2009.00641.x"},{"key":"10.14639\/0392-100X-N2955_ref18","doi-asserted-by":"crossref","unstructured":"Mascarella MA, Mannard E, Silva SD, et al. Neutrophil-to-lymphocyte ratio in head and neck cancer prognosis: a systematic review and meta-analysis. Head Neck 2018;40:1091-1100. https:\/\/doi.org\/10.1002\/hed.25075","DOI":"10.1002\/hed.25075"},{"key":"10.14639\/0392-100X-N2955_ref19","doi-asserted-by":"crossref","unstructured":"Bojaxhiu B, Templeton AJ, Elicin O, et al. Relation of baseline neutrophil-to-lymphocyte ratio to survival and toxicity in head and neck cancer patients treated with (chemo-) radiation. Radiat Oncol 2018;13:216. https:\/\/doi.org\/10.1186\/s13014-018-1159-y","DOI":"10.1186\/s13014-018-1159-y"},{"key":"10.14639\/0392-100X-N2955_ref20","doi-asserted-by":"crossref","unstructured":"Davis AN, Afshar-Kharghan V, Sood AK. Platelet effects on ovarian cancer. Semin Oncol 2014;41:378-384. https:\/\/doi.org\/10.1053\/j.seminoncol.2014.04.004","DOI":"10.1053\/j.seminoncol.2014.04.004"},{"key":"10.14639\/0392-100X-N2955_ref21","doi-asserted-by":"crossref","unstructured":"Tan D, Fu Y, Su Q, et al. Prognostic role of platelet-lymphocyte ratio in colorectal cancer: a systematic review and meta-analysis. Medicine (Baltimore) 2016;95:E3837. https:\/\/doi.org\/10.1097\/MD.0000000000003837","DOI":"10.1097\/MD.0000000000003837"},{"key":"10.14639\/0392-100X-N2955_ref22","doi-asserted-by":"crossref","unstructured":"Rachidi S, Wallace K, Day TA, et al. Lower circulating platelet counts and antiplatelet therapy independently predict better outcomes in patients with head and neck squamous cell carcinoma. J Hematol Oncol 2014;7:65. https:\/\/doi.org\/10.1186\/s13045-014-0065-5","DOI":"10.1186\/s13045-014-0065-5"},{"key":"10.14639\/0392-100X-N2955_ref23","doi-asserted-by":"crossref","unstructured":"Tang H, Lu W, Li B, et al. Prognostic significance of neutrophil-to-lymphocyte ratio in biliary tract cancers: a systematic review and meta-analysis. Oncotarget 2017;8:36857-36868. https:\/\/doi.org\/10.18632\/oncotarget.16143","DOI":"10.18632\/oncotarget.16143"},{"key":"10.14639\/0392-100X-N2955_ref24","doi-asserted-by":"crossref","unstructured":"Boscolo-Rizzo P, D\u2019Alessandro A, Polesel J, et al. Different inflammatory blood markers correlate with specific outcomes in incident HPV-negative head and neck squamous cell carcinoma: a retrospective cohort study. BMC Cancer 2022;22:243. https:\/\/doi.org\/10.1186\/s12885-022-09327-4","DOI":"10.1186\/s12885-022-09327-4"},{"key":"10.14639\/0392-100X-N2955_ref25","doi-asserted-by":"crossref","unstructured":"Borsetto D, Sethi M, Polesel J, et al. The risk of recurrence in surgically treated head and neck squamous cell carcinomas: a conditional probability approach. Acta Oncol 2021;60:942-947. https:\/\/doi.org\/10.1080\/0284186X.2021.1925343","DOI":"10.1080\/0284186X.2021.1925343"},{"key":"10.14639\/0392-100X-N2955_ref26","doi-asserted-by":"crossref","unstructured":"Gaudioso P, Borsetto D, Tirelli G, et al. Advanced lung cancer inflammation index and its prognostic value in HPV-negative head and neck squamous cell carcinoma: a multicentre study. Support Care Cancer 2021;29:4683-4691. https:\/\/doi.org\/10.1007\/s00520-020-05979-9","DOI":"10.1007\/s00520-020-05979-9"},{"key":"10.14639\/0392-100X-N2955_ref27","doi-asserted-by":"crossref","unstructured":"Boscolo-Rizzo P, Zanelli E, Giudici F, et al. Prognostic value of H-index in patients surgically treated for squamous cell carcinoma of the larynx. Laryngoscope Investig Otolaryngol 2021;6:729-737. https:\/\/doi.org\/10.1002\/lio2.603","DOI":"10.1002\/lio2.603"},{"key":"10.14639\/0392-100X-N2955_ref28","doi-asserted-by":"crossref","unstructured":"Granja S, Tavares-Valente D, Queir\u00f3s O, et al. Value of pH regulators in the diagnosis, prognosis and treatment of cancer. Semin Cancer Biol 2017;43:17-34. https:\/\/doi.org\/10.1016\/j.semcancer.2016.12.003","DOI":"10.1016\/j.semcancer.2016.12.003"},{"key":"10.14639\/0392-100X-N2955_ref29","doi-asserted-by":"crossref","unstructured":"Diakos CI, Charles KA, McMillan DC, et al. Cancer-related inflammation and treatment effectiveness. Lancet Oncol 2014;15:E493-E503. https:\/\/doi.org\/10.1016\/S1470-2045(14)70263-3","DOI":"10.1016\/S1470-2045(14)70263-3"},{"key":"10.14639\/0392-100X-N2955_ref30","doi-asserted-by":"crossref","unstructured":"Lu H, Ouyang W, Huang C. Inflammation, a key event in cancer development. Mol Cancer Res 2006;4:221-233. https:\/\/doi.org\/10.1158\/1541-7786.MCR-05-0261","DOI":"10.1158\/1541-7786.MCR-05-0261"},{"key":"10.14639\/0392-100X-N2955_ref31","doi-asserted-by":"crossref","unstructured":"Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010;140:883-899. https:\/\/doi.org\/10.1016\/j.cell.2010.01.025","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"10.14639\/0392-100X-N2955_ref32","doi-asserted-by":"crossref","unstructured":"Kumarasamy C, Tiwary V, Sunil K, et al. Prognostic utility of platelet-lymphocyte ratio, neutrophil-lymphocyte ratio and monocyte-lymphocyte ratio in head and neck cancers: a detailed PRISMA compliant systematic review and meta-analysis. Cancers (Basel) 2021;13:4166. https:\/\/doi.org\/10.3390\/cancers13164166","DOI":"10.3390\/cancers13164166"},{"key":"10.14639\/0392-100X-N2955_ref33","doi-asserted-by":"crossref","unstructured":"Tham T, Olson C, Khaymovich J, et al. The lymphocyte-to-monocyte ratio as a prognostic indicator in head and neck cancer: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol 2018;275:1663-1670. https:\/\/doi.org\/10.1007\/s00405-018-4972-x","DOI":"10.1007\/s00405-018-4972-x"},{"key":"10.14639\/0392-100X-N2955_ref34","doi-asserted-by":"crossref","unstructured":"Hasegawa T, Iga T, Takeda D, et al. Neutrophil-lymphocyte ratio associated with poor prognosis in oral cancer: a retrospective study. BMC Cancer 2020;20:568. https:\/\/doi.org\/10.1186\/s12885-020-07063-1","DOI":"10.1186\/s12885-020-07063-1"},{"key":"10.14639\/0392-100X-N2955_ref35","doi-asserted-by":"crossref","unstructured":"Yin J, Qin Y, Luo YK, et al. Prognostic value of neutrophil-to-lymphocyte ratio for nasopharyngeal carcinoma: a meta-analysis. Medicine (Baltimore) 2017;96:E7577. https:\/\/doi.org\/10.1097\/MD.0000000000007577","DOI":"10.1097\/MD.0000000000007577"},{"key":"10.14639\/0392-100X-N2955_ref36","doi-asserted-by":"crossref","unstructured":"Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009;6:E1000097. https:\/\/doi.org\/10.1371\/journal.pmed.1000097","DOI":"10.1371\/journal.pmed.1000097"},{"key":"10.14639\/0392-100X-N2955_ref37","doi-asserted-by":"crossref","unstructured":"Farhan-Alanie OM, McMahon J, McMillan DC. Systemic inflammatory response and survival in patients undergoing curative resection of oral squamous cell carcinoma. Br J Oral Maxillofac Surg 2015;53:126-131. https:\/\/doi.org\/10.1016\/j.bjoms.2014.10.007","DOI":"10.1016\/j.bjoms.2014.10.007"},{"key":"10.14639\/0392-100X-N2955_ref38","doi-asserted-by":"crossref","unstructured":"Haddad CR, Guo L, Clarke S, et al. Neutrophil-to-lymphocyte ratio in head and neck cancer. J Med Imaging Radiat Oncol 2015;59:514-519. https:\/\/doi.org\/10.1111\/1754-9485.12305","DOI":"10.1111\/1754-9485.12305"},{"key":"10.14639\/0392-100X-N2955_ref39","doi-asserted-by":"crossref","unstructured":"Kara M, Uysal S, Altini\u015fik U, et al. The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma. Eur Arch Otorhinolaryngol 2017;274:535-542. https:\/\/doi.org\/10.1007\/s00405-016-4250-8","DOI":"10.1007\/s00405-016-4250-8"},{"key":"10.14639\/0392-100X-N2955_ref40","doi-asserted-by":"crossref","unstructured":"Rassouli A, Saliba J, Castano R, et al. Systemic inflammatory markers as independent prognosticators of head and neck squamous cell carcinoma. Head Neck 2015;37:103-110. https:\/\/doi.org\/10.1002\/hed.23567","DOI":"10.1002\/hed.23567"},{"key":"10.14639\/0392-100X-N2955_ref41","doi-asserted-by":"crossref","unstructured":"Aoyama J, Kuwahara T, Sano D, et al. Combination of performance status and lymphocyte-monocyte ratio as a novel prognostic marker for patients with recurrent\/metastatic squamous cell carcinoma of the head and neck. Cancer Diagn Progn 2021;1:353-361. https:\/\/doi.org\/10.21873\/cdp.10047","DOI":"10.21873\/cdp.10047"},{"key":"10.14639\/0392-100X-N2955_ref42","doi-asserted-by":"crossref","unstructured":"Kano S, Homma A, Hatakeyama H, et al. Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer. Head Neck 2017;39:247-253. https:\/\/doi.org\/10.1002\/hed.24576","DOI":"10.1002\/hed.24576"},{"key":"10.14639\/0392-100X-N2955_ref43","doi-asserted-by":"crossref","unstructured":"Gao P, Peng W, Hu Y. Prognostic and clinicopathological significance of lymphocyte-to-monocyte ratio in patients with nasopharyngeal carcinoma. Head Neck 2022;44:624-632. https:\/\/doi.org\/10.1002\/hed.26952","DOI":"10.1002\/hed.26952"},{"key":"10.14639\/0392-100X-N2955_ref44","doi-asserted-by":"crossref","unstructured":"Yang J, Hsueh CY, Cao W, et al. Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for hypopharyngeal squamous cell carcinoma. Acta Otolaryngol 2018;138:734-740. https:\/\/doi.org\/10.1080\/00016489.2018.1449965","DOI":"10.1080\/00016489.2018.1449965"},{"key":"10.14639\/0392-100X-N2955_ref45","doi-asserted-by":"crossref","unstructured":"Tsai MH, Huang TL, Chuang HC, et al. Clinical significance of pretreatment prognostic nutritional index and lymphocyte-to-monocyte ratio in patients with advanced p16-negative oropharyngeal cancer-a retrospective study. Peer J 2020;8:E10465. https:\/\/doi.org\/10.7717\/peerj.10465","DOI":"10.7717\/peerj.10465"},{"key":"10.14639\/0392-100X-N2955_ref46","doi-asserted-by":"crossref","unstructured":"Valero C, Pardo L, L\u00f3pez M, et al. Pretreatment count of peripheral neutrophils, monocytes, and lymphocytes as independent prognostic factor in patients with head and neck cancer. Head Neck 2017;39:219-226. https:\/\/doi.org\/10.1002\/hed.24561","DOI":"10.1002\/hed.24561"},{"key":"10.14639\/0392-100X-N2955_ref47","doi-asserted-by":"crossref","unstructured":"Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000;283:2008-2012. https:\/\/doi.org\/10.1001\/jama.283.15.2008","DOI":"10.1001\/jama.283.15.2008"},{"key":"10.14639\/0392-100X-N2955_ref48","doi-asserted-by":"crossref","unstructured":"Zhuang Y, Yuan BY, Hu Y, et al. Pre\/post-treatment dynamic of inflammatory markers has prognostic value in patients with small hepatocellular carcinoma managed by stereotactic body radiation therapy. Cancer Manag Res 2019;11:10929-10937. https:\/\/doi.org\/10.2147\/CMAR.S231901","DOI":"10.2147\/CMAR.S231901"},{"key":"10.14639\/0392-100X-N2955_ref49","doi-asserted-by":"crossref","unstructured":"Nechita VI, Al-Hajjar N, Moi\u015f E, et al. Inflammatory ratios as predictors for tumor invasiveness, metastasis, resectability and early postoperative evolution in gastric cancer. Curr Oncol 2022;29:9242-9254. https:\/\/doi.org\/10.3390\/curroncol29120724","DOI":"10.3390\/curroncol29120724"},{"key":"10.14639\/0392-100X-N2955_ref50","doi-asserted-by":"crossref","unstructured":"Moon G, Noh H, Cho IJ, et al. Prediction of late recurrence in patients with breast cancer: elevated neutrophil to lymphocyte ratio (NLR) at 5 years after diagnosis and late recurrence. Breast Cancer 2020;27:54-61. https:\/\/doi.org\/10.1007\/s12282-019-00994-z","DOI":"10.1007\/s12282-019-00994-z"},{"key":"10.14639\/0392-100X-N2955_ref51","doi-asserted-by":"crossref","unstructured":"Khunger M, Patil PD, Khunger A, et al. Post-treatment changes in hematological parameters predict response to nivolumab monotherapy in non-small cell lung cancer patients. PLoS One 2018;13:E0197743. https:\/\/doi.org\/10.1371\/journal.pone.0197743","DOI":"10.1371\/journal.pone.0197743"},{"key":"10.14639\/0392-100X-N2955_ref52","doi-asserted-by":"crossref","unstructured":"Lin CH, Chou WC, Wu YY, et al. Prognostic significance of dynamic changes in lymphocyte-to-monocyte ratio in patients with head and neck cancer treated with radiotherapy: results from a large cohort study. Radiother Oncol 2021;154:76-86. https:\/\/doi.org\/10.1016\/j.radonc.2020.09.012","DOI":"10.1016\/j.radonc.2020.09.012"},{"key":"10.14639\/0392-100X-N2955_ref53","doi-asserted-by":"crossref","unstructured":"Zakaria SS, Ramanathan A, Mat Ripen Z, et al. Prognostic abilities of pre- and post-treatment inflammatory markers in oral squamous cell carcinoma: stepwise modelling. Medicina (Kaunas) 2022;58:1426. https:\/\/doi.org\/10.3390\/medicina58101426","DOI":"10.3390\/medicina58101426"}],"container-title":["Acta Otorhinolaryngologica Italica"],"original-title":[],"link":[{"URL":"https:\/\/www.actaitalica.it\/article\/view\/1130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T08:05:31Z","timestamp":1742285131000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.actaitalica.it\/article\/view\/1130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"URL":"https:\/\/doi.org\/10.14639\/0392-100x-n2955","relation":{},"ISSN":["1827-675X"],"issn-type":[{"value":"1827-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"article-number":"2"}}