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For patients with PV and ET, the risk stratification of low- and high-risk disease requires only two parameters: older than age 60 and prior history of thrombosis. Additionally, it might be important to monitor leukocyte count and know the mutational profile. Survival of patients with MF is defined by the International Prognostic Scoring System (IPSS) model at diagnosis and the Dynamic IPSS (DIPSS) anytime during the course of the disease. The IPSS and the DIPSS are based on patient age older than age 65, presence of constitutional symptoms, hemoglobin level less than 10 g\/dL, leukocyte count greater than 25 \u00d7 10<jats:sup>9<\/jats:sup>\/L, and circulating blast cells 1% or greater. The DIPSS-plus adds critical prognostic information and suggests also considering cytogenetic categories, platelet count, and red blood cell transfusion need. <\/jats:p><\/jats:sec>","DOI":"10.14694\/edbook_am.2012.32.241","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T18:55:56Z","timestamp":1581101756000},"page":"419-424","source":"Crossref","is-referenced-by-count":2,"title":["Classification of Myeloproliferative Neoplasms and Prognostic Factors"],"prefix":"10.1200","author":[{"given":"Francesco","family":"Passamonti","sequence":"first","affiliation":[{"name":"From the Division of Hematology, Department of Internal Medicine, University Hospital Ospedale di Circolo e Fondazione Macchi, Varese, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-083501"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-315614"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.5298"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.06.032"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035572"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.3569"},{"key":"B7","doi-asserted-by":"crossref","unstructured":"Passamonti F. Prognostic factors and models in polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Clin Lymphoma Myeloma Leuk. 2011;suppl 1:S25-S27.","DOI":"10.1016\/j.clml.2011.01.002"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-064287"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.148"},{"key":"B10","doi-asserted-by":"crossref","unstructured":"Passamonti F, Elena C, Schnittger S, et al. Molecular and clinical features of the myeloproliferative neoplasm associated with JAK2 exon 12 mutations. 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IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: Clinical evidence for leukemogenic collaboration with JAK2V617F. Leukemia. Epub 2011 Sept 13.","DOI":"10.1038\/leu.2011.253"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-363424"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.225"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.3.1013.1013"},{"key":"B30","doi-asserted-by":"crossref","unstructured":"Tefferi A, Siragusa S, Hussein K, et al. Transfusion-dependency at presentation and its acquisition in the first year of diagnosis are both equally detrimental for survival in primary myelofibrosis-prognostic relevance is independent of IPSS or karyotype. 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