{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:31:18Z","timestamp":1791228678792,"version":"4.1.0"},"reference-count":43,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"34","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Society of Clinical Oncology Educational Book"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:p> Mantle cell lymphoma is molecularly characterized by the chromosomal translocation t(11;14) (q13;q32) that results in a constitutional overexpression of the cell cycle regulator protein cyclin D1. Generally, the disease is characterized by rapid relapses and poor long-term outcome. However, a subset of patients with indolent disease has been identified. Randomized trials have demonstrated the superiority of dose intensified, cytarabine-containing induction with or without autologous stem cell transplantation in younger patients. In elderly patients, a rituximab-based maintenance has significantly prolonged progression-free and overall survival after treatment with rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP). Unfortunately, the vast majority of patients will eventually relapse. Numerous molecular targeting strategies (bortezomib, lenalidomide, temsirolimus, and especially inhibitors of the B-cell receptor pathway) have achieved high response rates in phase II studies and should be strongly considered in relapsed disease. <\/jats:p>","DOI":"10.14694\/edbook_am.2014.34.191","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T16:56:43Z","timestamp":1401296203000},"page":"191-198","source":"Crossref","is-referenced-by-count":31,"title":["Mantle Cell Lymphoma: Biology, Clinical Presentation, and Therapeutic Approaches"],"prefix":"10.1200","author":[{"given":"Martin","family":"Dreyling","sequence":"first","affiliation":[{"name":"From the Department of Medicine III, University Hospital Gro\u00dfhadern\/LMU M\u00fcnchen, Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"bibr1-EdBookAM201434191","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid 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