{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:12:31Z","timestamp":1785222751964,"version":"3.55.0"},"reference-count":27,"publisher":"Charles University in Prague, Karolinum Press","issue":"2","license":[{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"vor","delay-in-days":681,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"tdm","delay-in-days":681,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med. (Hradec Kralove, Czech Repub.)"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>\n                    Activated hepatic stellate cells (HSC) are a\u00a0major source of fibrous proteins in cirrhotic liver. Inducing or accelerating their apoptosis is a\u00a0potential way of liver fibrosis treatment. Extracellular matrix (ECM) surrounding cells in tissue affects their differentiation, migration, proliferation and function. Type I\u00a0collagen is the main ECM component in fibrotic liver. We have examined how this protein modifies apoptosis of normal rat HSC induced by gliotoxin, cycloheximide and cytochalasin D in vitro and spontaneous apoptosis of HSC isolated from CCl\n                    <jats:sub>4<\/jats:sub>\n                    -damaged liver. We have found that type I\u00a0collagen gel enhances HSC apoptosis regardless of the agent triggering this process.\n                  <\/jats:p>","DOI":"10.14712\/18059694.2014.27","type":"journal-article","created":{"date-parts":[[2014,11,15]],"date-time":"2014-11-15T17:24:09Z","timestamp":1416072249000},"page":"73-79","source":"Crossref","is-referenced-by-count":1,"title":["EFFECT OF COLLAGEN I GEL ON APOPTOSIS OF RAT HEPATIC STELLATE 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