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(Hradec Kralove, Czech Repub.)"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The present article describes two unrelated cases of progressive myoclonic epilepsy (PME) of the Lafora\u2019s disease and Unverricht-Lundborg types who were treated with topiramate (TPM) as add-on therapy for their myoclonus. After the initiation of topiramate therapy both cases responded with marked decrease in myoclonic seizure frequency and improvement of quality of life. Topiramate appears to be a useful alternative agent in cases of PME and could be consider for adjunctive therapy.<\/jats:p>","DOI":"10.14712\/18059694.2014.37","type":"journal-article","created":{"date-parts":[[2014,11,15]],"date-time":"2014-11-15T17:25:20Z","timestamp":1416072320000},"page":"36-38","source":"Crossref","is-referenced-by-count":5,"title":["EFFICACY OF TOPIRAMATE AS ADD-ON THERAPY IN TWO DIFFERENT TYPES OF PROGRESSIVE MYOCLONIC EPILEPSY"],"prefix":"10.14712","volume":"56","author":[{"given":"Caner Feyzi","family":"Demir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan H\u00fcseyin","family":"\u00d6zdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fclent","family":"M\u00fcngen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2014,11,13]]},"reference":[{"key":"18059694.2014.37_1","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1093\/emboj\/cdg338","volume":"22","author":"Lehesjoki","year":"2003","journal-title":"EMBO J."},{"key":"18059694.2014.37_3","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.yebeh.2004.11.014","volume":"6","author":"Aykutlu","year":"2005","journal-title":"Epilepsy Behav."},{"key":"18059694.2014.37_4","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/BF02763047","volume":"73","author":"Fallah","year":"2006","journal-title":"Indian J Pediatr."},{"key":"18059694.2014.37_5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0920-1211(95)00105-0","volume":"24","author":"Wauquier","year":"1996","journal-title":"Epilepsy Res"},{"key":"18059694.2014.37_6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1528-1157.1997.tb04523.x","volume":"38","author":"White","year":"1997","journal-title":"Epilepsia"},{"key":"18059694.2014.37_7","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1212\/WNL.52.7.1330","volume":"52","author":"Biton","year":"1999","journal-title":"Neurology."},{"key":"18059694.2014.37_8","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1528-1157.2000.tb00282.x","volume":"4","author":"Stephen","year":"2000","journal-title":"Epilepsia."},{"key":"18059694.2014.37_9","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1212\/01.WNL.0000110193.78872.DD","volume":"62","author":"Crest","year":"2004","journal-title":"Neurology."},{"key":"18059694.2014.37_10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1136\/jnnp.69.5.636","volume":"69","author":"Thompson","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"18059694.2014.37_11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1528-1157.2000.tb02163.x","volume":"41","author":"Shank","year":"2000","journal-title":"Epilepsia"}],"container-title":["Acta Medica (Hradec Kralove, Czech Republic)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/actamedica.lfhk.cuni.cz\/media\/pdf\/am_2013056010036.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actamedica.lfhk.cuni.cz\/media\/pdf\/am_2013056010036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:40:18Z","timestamp":1779961218000},"score":1,"resource":{"primary":{"URL":"https:\/\/actamedica.lfhk.cuni.cz\/56\/1\/0036\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013]]}},"alternative-id":["am_2013056010036"],"URL":"https:\/\/doi.org\/10.14712\/18059694.2014.37","relation":{},"ISSN":["1211-4286","1805-9694"],"issn-type":[{"value":"1211-4286","type":"print"},{"value":"1805-9694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}