{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:35:09Z","timestamp":1791657309262,"version":"4.3.4"},"reference-count":53,"publisher":"Charles University in Prague, Karolinum Press","issue":"2","license":[{"start":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T00:00:00Z","timestamp":1440633600000},"content-version":"vor","delay-in-days":238,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T00:00:00Z","timestamp":1440633600000},"content-version":"tdm","delay-in-days":238,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["SV\/FVZ201203"],"award-info":[{"award-number":["SV\/FVZ201203"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med. (Hradec Kralove, Czech Repub.)"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Acetylcholinesterase is an enzyme responsible for termination of excitatory transmission at cholinergic synapses by the hydrolyzing of a neurotransmitter acetylcholine. Nowadays, other functions of acetylcholinesterase in the organism are considered, for example its role in regulation of apoptosis. Cholinergic nervous system as well as acetylcholinesterase activity is closely related to pathogenesis of Alzheimer disease. The mostly used therapy of Alzheimer disease is based on enhancing cholinergic function using inhibitors of acetylcholinesterase like rivastigmine, donepezil or galantamine. These drugs can influence not only the acetylcholinesterase activity but also other processes in treated organism. The paper is aimed mainly on possibility of increased expression and protein level of acetylcholinesterase caused by the therapy with acetylcholinesterase inhibitors.<\/jats:p>","DOI":"10.14712\/18059694.2015.91","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T03:08:41Z","timestamp":1440644921000},"page":"37-42","source":"Crossref","is-referenced-by-count":15,"title":["Possibility of Acetylcholinesterase Overexpression in Alzheimer Disease Patients after Therapy with Acetylcholinesterase Inhibitors"],"prefix":"10.14712","volume":"58","author":[{"given":"Al\u017eb\u011bta","family":"Kra\u010dmarov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Drtinov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Pohanka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2015,8,27]]},"reference":[{"key":"18059694.2015.91_1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.mehy.2004.02.031","volume":"63","author":"Shen","year":"2004","journal-title":"Med Hypotheses"},{"key":"18059694.2015.91_2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0197-0186(95)00099-2","volume":"28","author":"Small","year":"1996","journal-title":"Neurochem Int"},{"key":"18059694.2015.91_3","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1755-5949.2010.00177.x","volume":"17","author":"Medeiros","year":"2011","journal-title":"Neurosci Ther"},{"key":"18059694.2015.91_4","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jalz.2010.03.007","volume":"6","author":"Weiner","year":"2010","journal-title":"Alzheimers Dement"},{"key":"18059694.2015.91_5","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.bbadis.2011.08.005","volume":"1812","author":"Mao","year":"2011","journal-title":"BBA Mol Basis Dis"},{"key":"18059694.2015.91_6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cbi.2010.01.042","volume":"187","author":"Dvir","year":"2010","journal-title":"Chem Biol Interact"},{"key":"18059694.2015.91_7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrn1035","volume":"4","author":"Darvesh","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"18059694.2015.91_8","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1126\/science.2274786","volume":"250","author":"Dougherty","year":"1990","journal-title":"Science"},{"key":"18059694.2015.91_9","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3390\/ph4020382","volume":"4","author":"Kozurkova","year":"2011","journal-title":"Pharmaceuticals"},{"key":"18059694.2015.91_10","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.neubiorev.2011.03.001","volume":"35","author":"Craig","year":"2011","journal-title":"Neurosci Biobehav R"},{"key":"18059694.2015.91_11","doi-asserted-by":"crossref","first-page":"23646","DOI":"10.1074\/jbc.271.39.23646","volume":"271","author":"Pang","year":"1996","journal-title":"J Biol Chem"},{"key":"18059694.2015.91_12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/jnnp.66.2.137","volume":"66","author":"Francis","year":"1999","journal-title":"J Neurol Neurosur Ps"},{"key":"18059694.2015.91_13","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/bj2600625","volume":"260","author":"Chatonnet","year":"1989","journal-title":"Biochem J"},{"key":"18059694.2015.91_14","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/j.lfs.2007.03.008","volume":"80","author":"Paraoanu","year":"2007","journal-title":"Life Sci"},{"key":"18059694.2015.91_15","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/sj.cdd.4401034","volume":"9","author":"Zhang","year":"2002","journal-title":"Cell Death Differ"},{"key":"18059694.2015.91_16","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/jcb.20530","volume":"96","author":"Thullbery","year":"2005","journal-title":"J Cell Biochem"},{"key":"18059694.2015.91_17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejphar.2009.03.002","volume":"609","author":"Pettersson","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"18059694.2015.91_18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(98)00320-6","volume":"248","author":"Choi","year":"1998","journal-title":"Neurosci Lett"},{"key":"18059694.2015.91_19","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/S0047-6374(01)00309-8","volume":"122","author":"Talesa","year":"2001","journal-title":"Mech Ageing Dev"},{"key":"18059694.2015.91_20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.biopha.2008.02.005","volume":"62","author":"Shah","year":"2008","journal-title":"Biomed Pharmacoter"},{"key":"18059694.2015.91_21","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0009-8981(88)90152-0","volume":"171","author":"Bonham","year":"1999","journal-title":"Clin Chim Acta"},{"key":"18059694.2015.91_22","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.1471-4159.2002.00902.x","volume":"81","author":"Fodero","year":"2002","journal-title":"J Neurochem"},{"key":"18059694.2015.91_23","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0896-6273(00)80108-7","volume":"16","author":"Inestrosa","year":"1996","journal-title":"Neuron"},{"key":"18059694.2015.91_24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/NEN.0b013e31823cc7a6","volume":"71","author":"Darvesh","year":"2012","journal-title":"J Neuropathol Exp Neurol"},{"key":"18059694.2015.91_25","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0006-2952(02)01514-9","volume":"65","author":"Bartolini","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"18059694.2015.91_26","first-page":"e23","volume":"33","author":"Silveyra","year":"2012","journal-title":"Neurobiol Aging"},{"key":"18059694.2015.91_27","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1177\/106002809402800612","volume":"28","author":"Crismon","year":"1994","journal-title":"Ann Pharmacother"},{"key":"18059694.2015.91_28","doi-asserted-by":"crossref","first-page":"510","DOI":"10.2165\/00002512-199404060-00006","volume":"4","author":"Wagstaff","year":"1994","journal-title":"Drug & Aging"},{"key":"18059694.2015.91_29","doi-asserted-by":"crossref","first-page":"6588","DOI":"10.1016\/j.bmc.2005.09.029","volume":"13","author":"Alonso","year":"2005","journal-title":"Bioorg Med Chem"},{"key":"18059694.2015.91_30","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ejps.2011.10.002","volume":"44","author":"Luppi","year":"2011","journal-title":"Eur J Pharm Sci"},{"key":"18059694.2015.91_31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.coph.2005.09.007","volume":"6","author":"Johnson","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"18059694.2015.91_32","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0969-2126(99)80040-9","volume":"7","author":"Kryger","year":"1999","journal-title":"Structure"},{"key":"18059694.2015.91_33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1527-3458.2002.tb00221.x","volume":"8","author":"Lilienfeld","year":"2002","journal-title":"CNS Drug Rev"},{"key":"18059694.2015.91_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1592\/phco.20.1.1.34664","volume":"20","author":"Jann","year":"2000","journal-title":"Pharmacotherapy"},{"key":"18059694.2015.91_35","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3233\/JAD-130845","volume":"39","author":"Darreh-Shori","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"18059694.2015.91_36","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1742-1241.2002.tb11235.x","volume":"56","author":"Bullock","year":"2002","journal-title":"Int J Clin Pract"},{"key":"18059694.2015.91_37","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0304-3940(01)01586-5","volume":"300","author":"Davidsson","year":"2001","journal-title":"Neurosci Lett"},{"key":"18059694.2015.91_38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s100720200086","volume":"23","author":"Parnetti","year":"2002","journal-title":"Neurol Sci"},{"key":"18059694.2015.91_39","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1046\/j.1471-4159.2003.02230.x","volume":"88","author":"Darreh-Shori","year":"2004","journal-title":"J Neurochem"},{"key":"18059694.2015.91_40","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1007\/s00702-006-0526-2","volume":"113","author":"Darreh-Shori","year":"2006","journal-title":"J Neural Transm"},{"key":"18059694.2015.91_41","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1111\/j.1471-4159.2007.04461.x","volume":"101","author":"Garc\u00eda-Ayll\u00f3n","year":"2007","journal-title":"J Neurochem"},{"key":"18059694.2015.91_42","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/S0047-6374(01)00314-1","volume":"122","author":"Amici","year":"2001","journal-title":"Mech Ageing Develop"},{"key":"18059694.2015.91_43","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/0006-2952(95)00004-J","volume":"19","author":"Chiappa","year":"1995","journal-title":"Biochem Pharmacol"},{"key":"18059694.2015.91_44","first-page":"168","volume":"20","author":"Zivin","year":"2008","journal-title":"Psychiatr Danub"},{"key":"18059694.2015.91_45","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/30741","volume":"393","author":"Kaufer","year":"1998","journal-title":"Nature"},{"key":"18059694.2015.91_46","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1600-0404.1998.tb00645.x","volume":"97","author":"Cutler","year":"1998","journal-title":"Acta Neurol Scand"},{"key":"18059694.2015.91_47","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/ana.21345","volume":"63","author":"Kadir","year":"2008","journal-title":"Ann Neurol"},{"key":"18059694.2015.91_48","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1046\/j.1471-4159.2000.740777.x","volume":"74","author":"Hellstr\u00f6m-Lindahl","year":"2000","journal-title":"J Neurochem"},{"key":"18059694.2015.91_49","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem Pharmacol"},{"key":"18059694.2015.91_50","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3389\/fnmol.2011.00022","volume":"4","author":"Garc\u00eda-Ayll\u00f3n","year":"2011","journal-title":"Front Mol Neurosci"},{"key":"18059694.2015.91_51","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/clinchem\/29.6.1061","volume":"29","author":"N\u00f8rgaard-Pedersen","year":"1983","journal-title":"Clin Chem"},{"key":"18059694.2015.91_52","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1016\/S0021-9258(17)43152-8","volume":"259","author":"Lazar","year":"1984","journal-title":"J Biol Chem"},{"key":"18059694.2015.91_53","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tox.2014.09.004","volume":"325","author":"Del Pino","year":"2014","journal-title":"Toxicology"}],"container-title":["Acta Medica (Hradec Kralove, Czech Republic)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/actamedica.lfhk.cuni.cz\/media\/pdf\/am_2015058020037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actamedica.lfhk.cuni.cz\/media\/pdf\/am_2015058020037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:42:57Z","timestamp":1779961377000},"score":1,"resource":{"primary":{"URL":"https:\/\/actamedica.lfhk.cuni.cz\/58\/2\/0037\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015]]}},"alternative-id":["am_2015058020037"],"URL":"https:\/\/doi.org\/10.14712\/18059694.2015.91","relation":{},"ISSN":["1211-4286","1805-9694"],"issn-type":[{"value":"1211-4286","type":"print"},{"value":"1805-9694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}