{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:09:20Z","timestamp":1779962960571,"version":"3.53.1"},"reference-count":31,"publisher":"Charles University in Prague, Karolinum Press","issue":"2","license":[{"start":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T00:00:00Z","timestamp":1440633600000},"content-version":"vor","delay-in-days":238,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T00:00:00Z","timestamp":1440633600000},"content-version":"tdm","delay-in-days":238,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med. (Hradec Kralove, Czech Repub.)"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    Aim\/background:\n                    <jats:italic>Pistacia terebinthus<\/jats:italic>\n                    is used as a coffee substitute in the East and Southern Anatolia regions of Turkey. It contains unsaturated fatty acids, tocopherols, polyphenols and carotenoids.\n                    <jats:italic>P. terebinthus<\/jats:italic>\n                    has anti-inflammatory and potential antioxidant activity. In this study we evaluated the protective effects of\n                    <jats:italic>P. terebinthus<\/jats:italic>\n                    coffee (\n                    <jats:italic>PTC<\/jats:italic>\n                    ) on thioacetamide (TAA)-induced liver injury in rats. Materials and methods: Twenty-eight male Sprague-Dawley rats were equally randomized into four groups. Chronic liver injury was induced with TAA (100 mg\/kg i.p. three times weekly). The first group of rats served as control and received only tap water (G1), and the remaining groups of rats received\n                    <jats:italic>PTC<\/jats:italic>\n                    , p.o (G2); TAA (G3); TAA plus\n                    <jats:italic>PTC<\/jats:italic>\n                    , p.o (G4), respectively. Results: After 8 weeks,\n                    <jats:italic>PTC<\/jats:italic>\n                    intake significantly reduced fibrosis\/inflammation scores (p &lt; 0.05) in the livers of TAA-treated group. Compared to control group,\n                    <jats:italic>PTC<\/jats:italic>\n                    intake reduced transforming growth factor beta (TGF-\u03b2) concentrations in the liver (p &lt; 0.05). Compared to the TAA group, TGF-\u03b2, nuclear factor kappa B (NF)-\u03baB (p &lt; 0.05), tumor necrosis factor alpha (TNF-\u03b1) concentrations in the liver tissue were reduced by\n                    <jats:italic>PTC<\/jats:italic>\n                    intake. Discussion and conclusion:\n                    <jats:italic>PTC<\/jats:italic>\n                    intake provided beneficial effects against TAA-induced liver injury in rats.\n                    <jats:italic>PTC<\/jats:italic>\n                    probably suppresses the proinflammatory cytokines through NF-\u03baB signaling pathway.\n                  <\/jats:p>","DOI":"10.14712\/18059694.2015.94","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T03:08:41Z","timestamp":1440644921000},"page":"56-61","source":"Crossref","is-referenced-by-count":4,"title":["Pistacia Terebinthus Coffee Protects against Thioacetamide-Induced Liver Injury in Rats"],"prefix":"10.14712","volume":"58","author":[{"given":"Ibrahim 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