{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:09:48Z","timestamp":1779962988030,"version":"3.53.1"},"reference-count":31,"publisher":"Charles University in Prague, Karolinum Press","issue":"2","license":[{"start":{"date-parts":[[2016,5,22]],"date-time":"2016-05-22T00:00:00Z","timestamp":1463875200000},"content-version":"vor","delay-in-days":1968,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,5,22]],"date-time":"2016-05-22T00:00:00Z","timestamp":1463875200000},"content-version":"tdm","delay-in-days":1968,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med. (Hradec Kralove, Czech Repub.)"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>This study was designed to investigate the effects of melatonin on the bladder hyperactivity in hyperosmolar-induced overactive bladder (OAB) rats. Additionally, the influence of melatonin on the autonomic nervous system (ANS) using heart rate variability (HRV) analysis was assessed. 40 rats were divided into four groups: I \u2013 control (n=12), II \u2013 rats with hyperosmolar OAB (n=6), III \u2013 rats with melatonin pretreatment and hyperosmolar OAB (n=6) and IV \u2013 control with melatonin pretreatment (n=6). In group III and IV melatonin in dose of 100 mg\/kg was given. HRV measurements in 10 rats, as follow: control (n=2), control after melatonin treatment (n=2), rats with hyperosmolar OAB without (n=3), and after (n=3) melatonin treatment were conducted. This study demonstrates marked influence of melatonin on urinary bladder activity in hyperosmolar-induced OAB rats. These rats showed significantly reduced the detrusor motor overactivity resulting in the improvement of cystometric parameters after melatonin treatment when compared to the control, as follow: a significant increase of intercontraction interval (70 %) and functional bladder capacity (67 %), as well as a decrease of the basal pressure, detrusor overactivity index and motility index of 96 %, 439 % and 40 %, respectively. ANS activity analysis revealed sympathetic overactivity in OAB rats, and parasympathetic superiority in melatonin treated OAB rats. Melatonin treatment in rats with hyperosmolar OAB (group III) caused significant increase of nuHF parameter (from 51.00 \u00b1 25.29 to 76.97 \u00b1 17.43), as well as a decrease of nuLF parameter (from 49.01 \u00b1 25.26 to 23.03 \u00b1 17.43) and LF\/HF ratio (from 1.280 \u00b1 0.980 to 0.350 \u00b1 0.330). In conclusion, melatonin suppresses hyperosmolar OAB, and modulates ANS activity by inhibition of the sympathetic drive. Therefore, melatonin may become a useful agent for OAB management.<\/jats:p>","DOI":"10.14712\/18059694.2016.20","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:50:04Z","timestamp":1464051004000},"page":"63-68","source":"Crossref","is-referenced-by-count":6,"title":["The Ameliorating Effect of Exogenous Melatonin on Urinary Bladder Function in Hyperosmolar Bladder Overactivity and its Influence on the Autonomic Nervous System 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