{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:07:10Z","timestamp":1779962830394,"version":"3.53.1"},"reference-count":10,"publisher":"Charles University in Prague, Karolinum Press","issue":"3","license":[{"start":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T00:00:00Z","timestamp":1461196800000},"content-version":"vor","delay-in-days":1937,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T00:00:00Z","timestamp":1461196800000},"content-version":"tdm","delay-in-days":1937,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["N\u00b011344-4\/2010"],"award-info":[{"award-number":["N\u00b011344-4\/2010"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med. (Hradec Kralove, Czech Repub.)"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>Only a few cases of pneumocystis pneumonia (PCP) in Cushing\u2019s syndrome have been published in the literature so far. In the majority of these patients, the pneumonia occurred after reduction of the hypercortisolism with medicamentous treatment. We report two cases of PCP during conservative treatment of hypercortisolism. We describe clinical, imaging and laboratory findings in two patients and review published cases of pneumocystits pneumonia in Cushing\u2019s syndrome. A 60-year-old woman and 20-year-old man with Cushing\u2019s syndrome due to ectopic ACTH syndrome were treated at our department. Both developed pneumocystis pneumonia early after treatment with ketoconazole and ethomidate bromide had been introduced and the levels of cortisol rapidly decreased. PCP prophylaxis in patients with high cortisolemia should be started before treatment of hypercortisolism in current practice. Gradual lowering of plasma cortisol should also reduce the risk of infection by Pneumocystis jiroveci.<\/jats:p>","DOI":"10.14712\/18059694.2016.35","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T04:07:29Z","timestamp":1461211649000},"page":"127-130","source":"Crossref","is-referenced-by-count":9,"title":["Pneumocystis Pneumonia During Medicamentous Treatment of Cushing\u2019s Syndrome \u2013 A Description of Two Cases"],"prefix":"10.14712","volume":"54","author":[{"given":"Filip","family":"Gabalec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al\u017eb\u011bta","family":"Zav\u0159elov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Havel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"jr.","given":"Jaroslav","family":"Cerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Radocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Svilias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"\u010c\u00e1p","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2016,4,21]]},"reference":[{"key":"18059694.2016.35_1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1055\/s-2008-1062729","volume":"116","author":"Arlt","year":"2008","journal-title":"Exp Clin Endocrinol Diabetes."},{"key":"18059694.2016.35_2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF03350337","volume":"21","author":"Bakker","year":"1998","journal-title":"J Endocrinol Invest."},{"key":"18059694.2016.35_3","first-page":"1559","volume":"15","author":"Frenkel","year":"1966","journal-title":"Lab Invest."},{"key":"18059694.2016.35_4","doi-asserted-by":"crossref","first-page":"334","DOI":"10.7326\/0003-4819-101-3-334","volume":"101","author":"Graham","year":"1984","journal-title":"Ann Intern Med."},{"key":"18059694.2016.35_5","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0140-6736(06)68146-4","volume":"367","author":"Keenan","year":"2006","journal-title":"Lancet."},{"key":"18059694.2016.35_6","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1055\/s-2000-5810","volume":"108","author":"Kim","year":"2000","journal-title":"Exp Clin Endocrinol Diabetes."},{"key":"18059694.2016.35_7","first-page":"512","volume":"86","author":"McQuillen","year":"1991","journal-title":"Am J Gastroenterol."},{"key":"18059694.2016.35_8","first-page":"215","volume":"65","author":"Oosterhuis","year":"2007","journal-title":"Neth J Med."},{"key":"18059694.2016.35_9","first-page":"42","volume":"85","author":"Sarlis","year":"2000","journal-title":"J Clin Endocrinol Metab."},{"key":"18059694.2016.35_10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1471-2334-4-57","volume":"4","author":"Wu","year":"2004","journal-title":"BMC Infect Dis."}],"container-title":["Acta Medica (Hradec Kralove, Czech Republic)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/actamedica.lfhk.cuni.cz\/media\/pdf\/am_2011053030127.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actamedica.lfhk.cuni.cz\/media\/pdf\/am_2011053030127.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:35:00Z","timestamp":1779960900000},"score":1,"resource":{"primary":{"URL":"https:\/\/actamedica.lfhk.cuni.cz\/54\/3\/0127\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011]]}},"alternative-id":["am_2011053030127"],"URL":"https:\/\/doi.org\/10.14712\/18059694.2016.35","relation":{},"ISSN":["1211-4286","1805-9694"],"issn-type":[{"value":"1211-4286","type":"print"},{"value":"1805-9694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}