{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:19:47Z","timestamp":1780370387864,"version":"3.54.1"},"reference-count":20,"publisher":"Charles University in Prague, Karolinum Press","issue":"1","license":[{"start":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T00:00:00Z","timestamp":1461974400000},"content-version":"vor","delay-in-days":120,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T00:00:00Z","timestamp":1461974400000},"content-version":"tdm","delay-in-days":120,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Med. (Hradec Kralove, Czech Repub.)"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Still\u2019s disease is an inflammatory disorder of unknown etiology. First-line therapy is based on corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) but the frequency of relapses and corticosteroid-induced adverse events are limiting factors. The efficacy of intravenous tocilizumab (TCZ) has been shown at a dose of 8 mg\/kg but the corticosteroid-sparing effect of intravenous low-dose TCZ followed by subcutaneous (SC) injection in the course of the disease has been poorly investigated. We report the case of a 28-year old Caucasian woman presenting a relapse of Still\u2019s disease eleven months after diagnosis under treatment with 6 mg of methylprednisolone. TCZ at a dose of 4 mg\/kg every 2 weeks was combined with 32 mg of methylprednisolone, followed by 162 mg SC every 3 weeks. Evolution was rapidly favourable with a decrease in corticosteroid doses. We reviewed previously published cases.<\/jats:p>","DOI":"10.14712\/18059694.2016.51","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T15:55:31Z","timestamp":1462031731000},"page":"22-25","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of Low-Dose Tocilizumab on Relapsing Adult-Onset Still\u2019s Disease"],"prefix":"10.14712","volume":"59","author":[{"given":"Xavier","family":"Vandemergel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Vandergheynst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2016,4,30]]},"reference":[{"key":"18059694.2016.51_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/ard.30.2.121","volume":"30","author":"Bywaters","year":"1971","journal-title":"Ann Rheum 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