{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:08:49Z","timestamp":1779962929202,"version":"3.53.1"},"reference-count":41,"publisher":"Charles University in Prague, Karolinum Press","issue":"3","license":[{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"vor","delay-in-days":345,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"tdm","delay-in-days":345,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["actamedica.lfhk.cuni.cz"],"crossmark-restriction":true},"short-container-title":["Acta Med. (Hradec Kralove, Czech Repub.)"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>Background: Vasculopathy is a major cause of mortality and morbidity in Behcet\u2019s Disease (BD). Subclinical atherosclerosis can even be detected in the early stage of BD. Soluble tumor necrosis factor-like (TNF) weak inducer of apoptosis (TWEAK) is known as a good marker of the inflammation in vascular tree. The aim of this study is to examine the relationship between carotid artery intima-media thickness (cIMT) and serum TWEAK levels in patients with BD. Materials and Methods: In line with International BD Study Group criteria, 48 BD, and 30 controls were included in our study. Disease activity was evaluated according to BD current activity form (BDCAF). C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), lipid parameters, serum TWEAK levels, and cIMT were measured. Results: Disease activity score of BD patients was found as 2 (range 0\u20137). cIMT, serum TWEAK, CRP and ESR levels of BD patients were significantly higher comparing to cIMT (0.62 \u00b1 0.13 mm vs. 0.43 \u00b1 0.09 mm, p &lt; 0.001), serum TWEAK (667.5 \u00b1 130.6 vs. 603.4 \u00b1 89.6 pg\/ml, p = 0.015), CRP (3.9 \u00b1 4.3 vs. 1.4 \u00b1 1.0 mg\/dl, p &lt; 0.001) and ESR (10.2 \u00b1 10.0 vs. 5.6 \u00b1 3.7 mm\/h, p = 0.005) levels of the control group. There was a positive correlation between serum TWEAK level and disease activity (r = 0.251, p = 0.030) and cIMT (r = 0.463, p &lt; 0.001). Our study also revealed an independent correlation between cIMT and serum TWEAK levels (beta = 0.354, p &lt; 0.001). Conclusion: Increased serum TWEAK levels can play a part in the development of atherosclerotic heart disease in BD. Due to their liability to atherosclerosis, patients with BD must followed closely.<\/jats:p>","DOI":"10.14712\/18059694.2018.123","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T18:55:14Z","timestamp":1544640914000},"page":"86-92","update-policy":"https:\/\/doi.org\/10.14712\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Soluble Tumor Necrosis Factor (TNF)-Like Weak Inducer of Apoptosis (Tweak) Independently Predicts Subclinical Atherosclerosis in Behcet\u2019s Disease"],"prefix":"10.14712","volume":"61","author":[{"given":"Abdullah","family":"Icli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medine 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