{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:32:32Z","timestamp":1782930752418,"version":"3.54.5"},"reference-count":45,"publisher":"Charles University in Prague, Karolinum Press","issue":"1","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":90,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":90,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["actamedica.lfhk.cuni.cz"],"crossmark-restriction":true},"short-container-title":["Acta Med. (Hradec Kralove, Czech Repub.)"],"published-print":{"date-parts":[[2019]]},"abstract":"<jats:p>Background: Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease, characterized by widespread pain and somatic symptoms. The etiology has not yet been clarified. Oxidative stress may play an important role in FMS etiology. Thiol group is a very strong antioxidant. We aimed to investigate whether thiol\/disulfide homeostasis in FMS is altered or not. Material and methods: A total of 80 female FMS patients and 64 healthy female control individuals were included in this study. Thiol and disulfide values were measured by Erel\u2019s novel methods. Results: Native thiol (330.6 \u00b1 46.1 vs. 356.8 \u00b1 55.5 \u03bcmol\/L, p = 0.005) and native thiol\/total thiol (89.4 \u00b1 3.2 vs. 93.3 \u00b1 4.0, p &lt; 0.001) levels of FMS patients were significantly lower when compared to the values of control group. However, disulfide (19.4 \u00b1 6.3 vs. 12.2 \u00b1 6.3 \u03bcmol\/L, p &lt; 0.001) levels of FMS patients were significantly higher than healthy individuals. A negative correlation was found between the native thiol\/total thiol and fibromyalgia impact questionnaire (FIQ) score among the FMS patients. A positive correlation was found between disulfide values and FIQ score among the patients. Conclusions: In FMS patients, there was a significant correlation between the decrease in the thiol levels and an increase in the disulfide levels with the FIQ scores. We determined that thiol-disulfide rate was deteriorated in FMS patients and it increases in favor of disulfide amounts.<\/jats:p>","DOI":"10.14712\/18059694.2019.40","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T06:57:37Z","timestamp":1554101857000},"page":"12-18","update-policy":"https:\/\/doi.org\/10.14712\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Alteration of Thiol-Disulfide Homeostasis in Fibromyalgia Syndrome"],"prefix":"10.14712","volume":"62","author":[{"given":"Ayca","family":"Tuzcu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia 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