{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:09:24Z","timestamp":1779962964942,"version":"3.53.1"},"reference-count":15,"publisher":"Charles University in Prague, Karolinum Press","issue":"2","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":210,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"tdm","delay-in-days":210,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["actamedica.lfhk.cuni.cz"],"crossmark-restriction":true},"short-container-title":["Acta Med. (Hradec Kralove, Czech Repub.)"],"published-print":{"date-parts":[[2021]]},"abstract":"\n This study deals with detecting the associations of atopic dermatitis\u2019 (AD) phenotypes in children: alone or combined with seasonal allergic rhino-conjunctivitis (SARC) and\/or perennial allergic rhinitis (PAR), and\/or with bronchial asthma (BA) with single nucleotide polymorphisms (SNP) of filaggrin (\n FLG<\/jats:italic>\n ), thymic stromal lymphopoietin (\n TSLP<\/jats:italic>\n ) and orsomucoid-like-1 protein 3 (\n ORMDL3<\/jats:italic>\n ) genes. Male and female pediatric patients aged from 3 to 18 years old were recruited into the main (AD in different combinations with SARC, PAR, BA) and control groups (disorders of digestives system, neither clinical nor laboratory signs of atopy). Patients were genotyped for SNP of rs_7927894\n FLG<\/jats:italic>\n , rs_11466749\n TSLP<\/jats:italic>\n , rs_7216389\n ORMDL3<\/jats:italic>\n variants. Statistically significant associations of the increased risk were detected of AD combined with SARC and\/or PAR and AD combined with BA (possibly, SARC and\/or PAR) with C\/T rs_7927894\n FLG<\/jats:italic>\n and T\/T rs_7216389\n ORMDL3<\/jats:italic>\n genotypes. Genotype C\/C rs_7927894\n FLG<\/jats:italic>\n significantly decreases the risk of AD combined with SARC and\/or PAR by 2.56 fold. Several genotypes\u2019 associations had a trend to significance: C\/C rs_7216389\n ORMDL3<\/jats:italic>\n decreases and C\/T rs_7216389\n ORMDL3<\/jats:italic>\n increases the risk for developing AD alone phenotype; A\/G rs_11466749\n TSLP<\/jats:italic>\n decreases the risk of AD combined with BA (possibly, SARC and\/or PAR) phenotype development.\n <\/jats:p>","DOI":"10.14712\/18059694.2021.17","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T06:57:41Z","timestamp":1627714661000},"page":"96-100","update-policy":"https:\/\/doi.org\/10.14712\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Genotype Associations with the Different Phenotypes of Atopic Dermatitis in Children"],"prefix":"10.14712","volume":"64","author":[{"given":"Volodymyr","family":"Dytiatkovskyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetiana","family":"Drevytska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetiana","family":"Lapikova-Bryhinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Dosenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olexandr","family":"Abaturov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"18059694.2021.17_1","first-page":"354250","volume":"2014","author":"Thomsen","year":"2014","journal-title":"Allergy"},{"key":"18059694.2021.17_2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jaci.2018.11.006","volume":"143","author":"Paller","year":"2019","journal-title":"J Allergy ClinImmunol"},{"key":"18059694.2021.17_3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fped.2017.00044","volume":"5","author":"Licari","year":"2017","journal-title":"Front Pediatr"},{"key":"18059694.2021.17_4","first-page":"221","volume":"4","author":"Belgrave","year":"2015","journal-title":"CurrDerm Rep"},{"key":"18059694.2021.17_5","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/cea.13156","volume":"48","author":"Amat","year":"2018","journal-title":"Clin Exp Allergy"},{"key":"18059694.2021.17_6","first-page":"96","volume":"10","author":"Al-Shobaili","year":"2016","journal-title":"Int J Health Sci (Qassim)"},{"key":"18059694.2021.17_7","doi-asserted-by":"crossref","first-page":"020501","DOI":"10.11613\/BM.2019.020501","volume":"29","author":"\u010cepelak","year":"2019","journal-title":"Biochem Med (Zagreb)."},{"key":"18059694.2021.17_8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13223-016-0158-5","volume":"12","author":"Bin","year":"2016","journal-title":"Allergy Asthma Clin Immunol"},{"key":"18059694.2021.17_9","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1183\/09059180.00004314","volume":"23","author":"Li","year":"2014","journal-title":"Eur Respir Rev"},{"key":"18059694.2021.17_10","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/s41598-017-00670-2","volume":"7","author":"Wallmeyer","year":"2017","journal-title":"Sci Rep"},{"key":"18059694.2021.17_11","doi-asserted-by":"crossref","first-page":"4841","DOI":"10.1093\/hmg\/ddt317","volume":"22","author":"Weidinger","year":"2013","journal-title":"Hum Mol Genet"},{"key":"18059694.2021.17_12","unstructured":"Applied Biosystems 7500\/7500 Fast Real Time PCR System. Genotyping experiments. Getting started guide. 2010: Applied Biosystems. https:\/\/assets.thermofisher.com\/TFS-Assets\/LSG\/manuals \/4387784c.pdf"},{"key":"18059694.2021.17_13","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/jid.2011.393","volume":"132","author":"Brown","year":"2012","journal-title":"J Invest Dermatol"},{"key":"18059694.2021.17_14","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1093\/hmg\/dds243","volume":"21","author":"Fortugno","year":"2012","journal-title":"Hum Mol Genet"},{"key":"18059694.2021.17_15","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/j.1399-3038.2010.01073.x","volume":"21","author":"B\u00f8nnelykke","year":"2010","journal-title":"Pediatr Allergy Immunol"}],"container-title":["Acta Medica (Hradec Kralove, Czech Republic)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/actamedica.lfhk.cuni.cz\/media\/pdf\/am_2021064020096.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/actamedica.lfhk.cuni.cz\/media\/pdf\/am_2021064020096.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:38:35Z","timestamp":1779961115000},"score":1,"resource":{"primary":{"URL":"https:\/\/actamedica.lfhk.cuni.cz\/64\/2\/0096\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021]]}},"alternative-id":["am_2021064020096"],"URL":"https:\/\/doi.org\/10.14712\/18059694.2021.17","relation":{},"ISSN":["1211-4286","1805-9694"],"issn-type":[{"value":"1211-4286","type":"print"},{"value":"1805-9694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}