{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:14:20Z","timestamp":1782774860523,"version":"3.54.5"},"reference-count":25,"publisher":"Charles University in Prague, Karolinum Press","issue":"3","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":397,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"tdm","delay-in-days":397,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["actamedica.lfhk.cuni.cz"],"crossmark-restriction":true},"short-container-title":["Acta Med. (Hradec Kralove, Czech Repub.)"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>\n                    Candidemia is one of the significant causes of mortality amongst critically ill patients in Intensive Care Units (ICUs). This study aimed to assess the incidence, risk factors and antifungal susceptibility pattern in candidemia cases admitted in ICU in a tertiary care hospital in Jaipur, Rajasthan from June 2021 to November 2021.\n                    <jats:italic>Candida<\/jats:italic>\n                    species isolated from blood culture of clinically suspected patients of sepsis were defined as candidemia cases. Blood culture and antifungal susceptibility testing were performed as per standard laboratory protocol. Analyses of risk factors was done between candidemia cases and matched controls in a ratio of 1 : 3. Forty-six candidemic cases and 150 matched controls were included in the study.\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    was the most prevalent species (22\/46; 48%) followed by\n                    <jats:italic>C. auris<\/jats:italic>\n                    (8\/46; 17%) and\n                    <jats:italic>C. albicans<\/jats:italic>\n                    (7\/46; 15%).\n                    <jats:italic>Candida<\/jats:italic>\n                    species showed good sensitivity to echinocandins (97%) followed by amphotericin B (87%) and voriconazole (80%). In multivariate analysis, longer stay in ICU, presence of an indwelling device, use of immunosuppressive drugs and positive SARS-CoV-2 infection were associated with increased risk of candidemia. The constant evaluation of risk factors is required as prediction of risks associated with candidemia may help to guide targeted preventive measures with reduced morbidity and mortality.\n                  <\/jats:p>","DOI":"10.14712\/18059694.2022.23","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T15:48:23Z","timestamp":1675439303000},"page":"83-88","update-policy":"https:\/\/doi.org\/10.14712\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Risk Factors for Candidemia in Intensive Care Unit: A Matched Case Control Study from North-Western India"],"prefix":"10.14712","volume":"65","author":[{"given":"Ekadashi","family":"Rajni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpi","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogita","family":"Jangid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Vohra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"18059694.2022.23_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.4103\/0972-5229.148633","volume":"19","author":"Dasgupta","year":"2015","journal-title":"Indian J Crit Care Med"},{"key":"18059694.2022.23_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2147\/TCRM.S40160","volume":"10","author":"Yapar","year":"2014","journal-title":"Ther Clin Risk Manag"},{"key":"18059694.2022.23_3","doi-asserted-by":"crossref","unstructured":"Rajni E, Chaudhary P, Garg VK, Sharma R, Malik M. A complete clinico-epidemiological and microbiological profile of candidemia cases in a tertiary-care hospital in Western India. Antimicrobial Stewardship & Healthcare Epidemiology. Cambridge University Press 2022; 2(1): e37.","DOI":"10.1017\/ash.2021.235"},{"key":"18059694.2022.23_4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00134-014-3603-2","volume":"41","author":"Chakrabarti","year":"2015","journal-title":"Intensive Care Med"},{"key":"18059694.2022.23_5","first-page":"e24612","volume":"14","author":"Ahmad","year":"2022","journal-title":"Cureus"},{"key":"18059694.2022.23_6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13054-020-2766-1","volume":"24","author":"Poissy","year":"2020","journal-title":"Crit Care"},{"key":"18059694.2022.23_7","doi-asserted-by":"crossref","first-page":"ofab452","DOI":"10.1093\/ofid\/ofab452","volume":"8","author":"Rajni","year":"2021","journal-title":"Open Forum Infect Dis"},{"key":"18059694.2022.23_8","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s40121-022-00625-9","volume":"11","author":"Briano","year":"2022","journal-title":"Infect Dis Ther"},{"key":"18059694.2022.23_9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13756-019-0534-2","volume":"8","author":"Xiao","year":"2019","journal-title":"Antimicrob Resist Infect Control"},{"key":"18059694.2022.23_10","unstructured":"Clinical and Laboratory Standards Institute. Reference Method for Broth Dilution Anti\u2013Fungal Susceptibility Testing of Yeasts. CLSI Document M27. 4th ed. 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