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(Hradec Kralove, Czech Repub.)"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>We report a case of double aneuploidy in a preterm male newborn with karyotype 48,XXY,+18 whose mother was of advanced age and infected with the SARS-CoV-2 virus during the early stages of her pregnancy. The clinical features observed in the newborn included intrauterine growth retardation, dysmorphic facial features, overlapping fingers on both hands, respiratory distress syndrome, ventricular septal defect, patent ductus arteriosus, persistent pulmonary hypertension, and bilateral clubfoot, a phenotype that mainly correlates with Edwards syndrome (trisomy 18). To our knowledge, this is the first reported case of double aneuploidy in Croatia. This paper provides a detailed description of the clinical presentation and treatment strategies used, with the aim of providing valuable data for future recognition and management of similar cases. Furthermore, we discuss the mechanisms of nondisjunction that might account for this rare form of aneuploidy.<\/jats:p>","DOI":"10.14712\/18059694.2023.13","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T05:05:41Z","timestamp":1688015141000},"page":"32-36","update-policy":"https:\/\/doi.org\/10.14712\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["First Croatian Case of Double Aneuploidy: A Child With Klinefelter and Edwards Syndrome (48,XXY,+18) \u2013 Possible Causes and Contributing Factors"],"prefix":"10.14712","volume":"66","author":[{"given":"Ena","family":"Batinovi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anet","family":"Papazovska Cherepnalkovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernarda","family":"Lozi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luka","family":"Brajkovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Zanchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Pavlov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Bucat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2023,6,29]]},"reference":[{"key":"18059694.2023.13_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s004390050638","volume":"101","author":"Reddy","year":"1997","journal-title":"Hum Genet"},{"key":"18059694.2023.13_2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(59)91891-4","volume":"1","author":"Ford","year":"1959","journal-title":"Lancet"},{"key":"18059694.2023.13_3","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4103\/0974-1208.147494","volume":"7","author":"Subramaniyam","year":"2014","journal-title":"J Hum Reprod Sci"},{"key":"18059694.2023.13_4","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.tjog.2011.10.014","volume":"50","author":"Chen","year":"2011","journal-title":"Taiwan J Obstet Gynecol"},{"key":"18059694.2023.13_5","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1093\/humrep\/dei406","volume":"21","author":"Diego-Alvarez","year":"2006","journal-title":"Hum Reprod"},{"key":"18059694.2023.13_6","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/pd.2429","volume":"30","author":"Micale","year":"2010","journal-title":"Prenat Diagn"},{"key":"18059694.2023.13_7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/ajmg.a.30306","volume":"134A","author":"Kovaleva","year":"2005","journal-title":"Am J Med Genet A"},{"key":"18059694.2023.13_8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejmg.2005.01.006","volume":"48","author":"Biri","year":"2005","journal-title":"Eur J Med Genet"},{"key":"18059694.2023.13_9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1515\/jpm.2010.075","volume":"38","author":"Begam","year":"2010","journal-title":"J Perinat Med"},{"key":"18059694.2023.13_10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4103\/0974-1208.147494","volume":"7","author":"Subramaniyam","year":"2014","journal-title":"J Hum Reprod Sci"},{"key":"18059694.2023.13_11","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1515\/jpm-2021-0343","volume":"50","author":"Golbasi","year":"2021","journal-title":"J Perinat Med"},{"key":"18059694.2023.13_12","unstructured":"Balasundaram P, Avulakunta ID. 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