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(Hradec Kralove, Czech Repub.)"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:p>Addison\u2019s disease (AD) is characterized by non-specific symptoms and electrolyte disorders, namely hyponatraemia and hyperkalaemia; rhabdomyolysis is uncommon. AD may manifest at onset with a life-threatening adrenal crisis which is triggered by stressful events. We describe the case of a young man who was hospitalized for severe myalgia and fatigue. Severe hypotonic hyponatraemia, rhabdomyolysis and hypotension were found; hormonal assessment unexpectedly revealed primary adrenal insufficiency. Saline infusion and intravenous hydrocortisone significantly improved the patient\u2019s condition and normalized sodium and muscle enzyme levels; thereafter, he was switched to oral steroid therapy. The autoimmune origin of AD was ascertained by the positivity of adrenal cortex autoantibodies and 21b-hydroxylase autoantibodies. The association of hyponatraemia and rhabdomyolysis may be the initial finding of an as yet unknown AD, which requires proper investigation and treatment.<\/jats:p>","DOI":"10.14712\/18059694.2025.16","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T06:27:21Z","timestamp":1750055241000},"page":"31-36","update-policy":"https:\/\/doi.org\/10.14712\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Two Hurt More Than One: Severe Hyponatraemia and Rhabdomyolysis as Presenting Features of Addison\u2019s 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