{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:11:11Z","timestamp":1779963071810,"version":"3.53.1"},"reference-count":35,"publisher":"Charles University in Prague, Karolinum Press","issue":"3","license":[{"start":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T00:00:00Z","timestamp":1416614400000},"content-version":"vor","delay-in-days":690,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T00:00:00Z","timestamp":1416614400000},"content-version":"tdm","delay-in-days":690,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prague Med. Rep."],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>There is epidemiological, geographical and immunological evidence suggesting that low environmental supplies of vitamin D3 may act as a\u202f risk factor for developing multiple sclerosis (MS), possibly due to dysfunction in\u202f the immunomodulatory properties of 25-hydroxyvitamin D3 (25-OH-D3) in\u202f the brain. The objective of this study is to measure the serum and cerebrospinal fluid (CSF) concentrations of 25-OH-D3 in\u202f MS patients during their relapsing phase. 52 patients with remitting-relapse and 58 patients with other non-inflammatory diseases of central and peripheral nervous system were entered into the study. Patients in \u202fboth groups were admitted for the first time to do diagnostic procedures and they were not on any other treatment for neurological disorders. The means and medians for serum levels of 25-OH-D3 in \u202fMS patients and control group were 10.64 \u00b1 9.2 ng\/ml (median: 9.6 ng\/ml) and 13.23 \u00b1 17.56 ng\/ml (median: 11.90 ng\/ml), respectively (p=0.328). CSF concentrations for the same values were 2.02 \u00b1 1.94 ng\/ml (median: 0.23 ng\/ml) and 3.28 \u00b1 2.96 (median: 0.29 ng\/ml), respectively (p=0.242). The differences between calculated numbers of serum\/CSF ratios were not statistically significant too. The serum and CSF concentrations of 25-OH-D3 in \u202fMS group were lower than the control counterpart without any statistical difference and the authors did not find any influence of serum 25-OH-D3 concentration on the CSF concentration based on the non-significant statistical difference between the serum\/CSF ratios in \u202ftwo study groups of MS patients and control cases.<\/jats:p>","DOI":"10.14712\/23362936.2014.18","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T09:52:08Z","timestamp":1417168328000},"page":"162-171","source":"Crossref","is-referenced-by-count":11,"title":["25-hydroxyvitamin D3 Concentration in Serum and Cerebrospinal Fluid of Patients with Remitting-relapse Multiple Sclerosis"],"prefix":"10.14712","volume":"114","author":[{"given":"Ali","family":"Moghtaderi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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