{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:12:31Z","timestamp":1779963151676,"version":"3.53.1"},"reference-count":10,"publisher":"Charles University in Prague, Karolinum Press","issue":"3","license":[{"start":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T00:00:00Z","timestamp":1416614400000},"content-version":"vor","delay-in-days":690,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T00:00:00Z","timestamp":1416614400000},"content-version":"tdm","delay-in-days":690,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prague Med. Rep."],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The predominant pathophysiological feature of homozygous sickle cell anemia (SCA) is the vaso-occlusion. Vaso-occlusion can be associated with painful crises, which are the primary reason for those patients to seek medical care. Vaso-occlusion is responsible for the acute chest syndrome (ACS) with large morbidity and mortality or more rarely (and especially in\u202fadults) for priapism and acute neurological events (strokes). A 10-year-old boy with homozygous SCA was admitted to the Pediatric Emergencies with painful vaso-occlusive crisis and fever. Initially he had normal chest X-ray but, after 24-hour-hospitalization, he developed \u2009ACS with new chest X-ray findings. He was treated with broad spectrum antibiotics, blood transfusions and bronchodilators and after a\u202f six-day treatment, he was significantly improved. The patient was discharged 13 days later with no other therapy at home. The possibility of \u2009ACS development should be still considered, even when a \u202fknown patient with SCA presents a \u202fpainful vaso-occlusive crisis with an initial normal chest X-ray. Therefore, repeated clinical examination is required and possible changes in\u202f the clinical status could indicate the necessity of a \u202fnew radiographic examination. In\u202f this way, early \u2009ACS could be recognized and the catastrophic consequences due to this syndrome could be avoided.<\/jats:p>","DOI":"10.14712\/23362936.2014.21","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T09:52:08Z","timestamp":1417168328000},"page":"180-185","source":"Crossref","is-referenced-by-count":2,"title":["Painful Vaso-occlusive Crisis as a Prodromal Phase of Acute Chest Syndrome. Is Only One Chest X-ray Enough? 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