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Rep."],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>The aim of the present study was to determine the effect of ketamine\/xylazine and pentobarbital anaesthesia on heart rate variability as a marker of autonomic nervous system activity. The experiments were performed in ketamine\/xylazine (10 mg\/kg\/15 mg\/kg) and pentobarbital (40 mg\/kg, i.p.) anaesthetized female Wistar rats, after adaptation to a light-dark cycle of 12 hours light: 12\u202fhours dark. Heart rate variability parameters (RR interval, power \u2009VLF (very low frequency), power LF (low frequency), power HF (high frequency) and relative powers) were evaluated during spontaneous breathing as a function of the light-dark cycle (LD cycle). Significant LD differences were found in the duration of RR intervals in ketamine\/xylazine compared with pentobarbital-anaesthetized rats. Correlation analysis revealed moderate dependency between the RR interval duration and HF and LF power parameters in ketamine\/xylazine anaesthesia in both light and dark parts of the cycle. In pentobarbital-anaesthetized rats, correlation analysis demonstrated a moderate dependence between RR interval duration and HF and \u2009VLF power parameters, but only in the dark part of the LD cycle. Ketamine\/xylazine anaesthesia increased parasympathetic activity, and suppressed sympathetic and baroreceptor activity independently of the light-dark cycle. LD differences in RR interval duration were not eliminated. Pentobarbital anaesthesia increased parasympathetic activity, decreased sympathetic and baroreceptor activity, and eliminated LD differences in RR interval duration.<\/jats:p>","DOI":"10.14712\/23362936.2014.25","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T09:51:11Z","timestamp":1417168271000},"page":"72-80","source":"Crossref","is-referenced-by-count":16,"title":["Autonomic Nervous System under Ketamine\/xylazine and Pentobarbital Anaesthesia in a Wistar Rat Model: A Chronobiological View"],"prefix":"10.14712","volume":"114","author":[{"suffix":"Jr.","given":"Pavol","family":"\u0160vorc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ba\u010dov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"\u0160vorc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bu\u017ega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"5727","published-online":{"date-parts":[[2014,11,22]]},"reference":[{"key":"23362936.2014.25_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1566-0702(00)00271-X","volume":"87","author":"Akine","year":"2001","journal-title":"Auton. 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